If you watched The Office (the original), you know how everything ties up at the conclusion of the “documentary.” But how many details can you remember? What’s David Brent up to these days? Did Tim return to University? Has Gareth gotten more or less creepy? Let us know what you know.

Take the Quiz: The Office Christmas Special

Today’s movie quote quiz focuses on three Farrelly Brothers comedies from the 1990s. Can you tell which movie each quote came from? When you’re done, if there’s a movie quote quiz you’d like to see, beg for it in the comments.

Take the Quiz: Dumb and Dumber, Kingpin, or There’s Something About Mary?

Our latest movie quote quiz takes us back to the late 1980s. Do you remember which movie contained these lines?

Take the Quiz: Uncle Buck, The ‘Burbs, or Innerspace?

Today’s movie quiz features some of the more quotable films of the last decade. Can you tell which movie contains each quote?

Take the Quiz: Anchorman, Zoolander, or Blades of Glory?

You know the presidents. You know the events. But do you know which president was in office during each moment in history? Let’s find out.

Take the Quiz: Who Was President?

The Simpsons is coming back for at least two more seasons (seasons 24 and 25). We’re using this news as an excuse to run these quizzes on our favorite Springfield residents.

Show us how much you know about one of the most comically tormented characters in television history, then come back and give us your favorite Milhouse quote.

Take the Quiz: Milhouse Van Houten

It’s hard not to love Kirk Van Houten, Springfield’s most pathetic denizen this side of Gil. How well do you know the former cracker factory manager who sired Milhouse and married Luann twice?

Take the Quiz: Kirk Van Houten

How much do you know about Springfield’s most endearing goofball? Feel free to leave your own favorite Ralph memories in the comments below, since I’m sure this quiz hasn’t covered everything.

Take the Quiz: Ralph Wiggum

Do you remember which classic cop comedy each quote came from? Let’s find out.

Take the Quiz: The Naked Gun, Dragnet, or Super Troopers?

We’ve chosen quotations from three classic school-themed movies: Summer School, Back to School and Fast Times at Ridgemont High. Your job is to pick which movie it came from. Do you have what it takes to earn your “seemingly useless pop culture knowledge” diploma from Mental Floss High?

Take the Quiz: Back to School, Summer School or Fast Times?

Automotive design has been headed in this direction for some time. Google recently toyed with a driverless vehicle, to questionable critical success, and the Lexus LX 360 L boasts a strikingly efficient self-parking system that uses sonar sensors to squeeze itself into desired locations.

It appears that automotive engineers are programming the people right out of the cars—or, more accurately, attempting to program the potential for human error out of the car.

Driverless cars, of course, are nothing new in pop culture. KITT from Knight Rider possessed very impressive self-navigating abilities, not to mention the ability to talk, print money, engage various cruise modes (including, curiously, “pursuit” and “super pursuit”), and operate a state-of-the-art medical scanner. Why all GPS devices are not programmed with William Daniels’ voice, by the way, is beyond me.
(Photo of KITT’s instrumentation, at left, by WikiMedia uploader Amux)

So, here’s the experiment: Help us design the perfect car of the future using creative features from pop culture. Do what Homer Simpson did for Powell Motors when he designed “The Homer” (at left). If you like the idea of your car having three horns because you can never find one when you’re mad, like his did, go for it. If you like that the horns play “La Cucaracha,” also like his did, even better.

Throw in some of the better fictional features—like the safety foam feature the police cars from Demolition Man offered—and toss out some of the less functional ones, like George Jetson’s single joystick steering mechanism. How did he alter his altitude, anyway? Think KITT’s turbo boost option was highly impractical? We’re fine with that—on the cutting room floor it goes… You see where I’m going with this.

What automotive design innovations from movies, cartoons, and television would you select to build your perfect car?

“The horse is one piece of a protein that normally we make and that can recognize the [long double-stranded DNA] made by the virus, and the man is something that triggers the cell-death pathway.”

Most viruses act “sort of like the aliens in the Alien movies,” explains Todd Rider, the co-author of the drug study. They enter a cell, replicate inside it, create double-stranded RNA, and destroy the cell from the inside. Up until now, most attempts to attack viruses with antiviral medications have been target specific, with each drug aimed at a particular strain of virus. This has allowed viruses to mutate or become resistant to any given medication.

According to this very illuminating National Geographic post, what DRACO does, inventively, is work with the body’s natural defenses to detect the whereabouts of virus-generated double-stranded RNA. The body naturally releases proteins that latch onto the viral RNA to prevent replication. DRACO hitches a ride with these proteins, then triggers the cell’s self-destruct mechanism when it locates a virus… halting it in its tracks.

Researchers believe that DRACO’s ability to work against multiple viruses simultaneously might signal a sea-change in the way we combat viral infections, much like antibiotics changed the way we dealt with bacterial infections. In addition to possibly eradicating major viruses like HIV, Ebola, and smallpox, the drug might one day help eliminate the supremely aggravating common cold. Though still in its early stages of development, and probably about ten years away from your local pharmacy’s highly ineffectual Cold and Flu remedy shelf, DRACO is doing its best Chiron impersonation against our most deadly viruses.