Here's a fun clip from the vault. Here's Ali G (Sacha Baron Cohen's character) interviewing a panel of science experts about science. The discussion begins: "Yo. Science. What is it all about? Techmology. What is that all about? Is it good or is it whack?" The panel consists of Dr. Jeremiah Baumann (Public Interest Research Group), Dr. Joseph Coates (Futorologist), Graham Molitor (President, Public Policy Forecasting), and Dr. Kent Hovind (Creationist). While I'll admit there's virtually zero science content in this clip, I feel like it counts as a science video nonetheless.
Representative quote: Ali G: "Will compooters ever be able to work out what 999999999999999999999999999999999999 multiplied by 9999999989999999.88998899999999999...." Expert: "The answer is yes."
Fair warning: there's a bit of evolution/creationism debate, and it does get mildly scatological towards the end.