Chronic Pain Happens Differently in Men and Women

iStock.com/PeopleImages
iStock.com/PeopleImages

Women often feel colder than men due to physical differences. Now, a new study shows that the two sexes have different biological processes underlying a specific kind of pain, too. As WIRED reports, research published in the journal Brain revealed that different cells and proteins were activated in men and women with neuropathic pain—a condition that is often chronic, with symptoms including a burning or shooting sensation. While scientists say further research is needed, these findings could potentially change the way we treat conditions involving chronic pain.

A team of Texas-based neurologists and neuroscientists looked for RNA expressions in the sensory neurons of spinal tumors that had been removed from eight women and 18 men. Some of the patients had pain as a result of nerve compression, while others had not experienced any chronic pain. While studying the neurons of women with pain, researchers noticed that protein-like molecules called neuropeptides, which modulate neurons, were highly activated. For the men, immune system cells called macrophages were most active.

"This represents the first direct human evidence that pain seems to be as sex-dependent in its underlying biology in humans as we have been suggesting for a while now, based on experiments in mice," Jeffrey Mogil, a professor of pain studies at Montreal's McGill University, who was not involved in the Brain study, tells WIRED.

So what exactly do these new findings mean for sufferers of chronic pain? Considering that clinical trials and drug manufacturers have traditionally failed to distinguish between the sexes when it comes to developing pain medication, the study could potentially form a foundation for sex-specific pain therapies that could prove more effective. This might be especially promising for women, who are more likely to have some condition that cause persistent pain, such as migraines or fibromyalgia.

"I think that 10 years from now, when I look back at how papers I've published have had an impact, this one will stick out," Dr. Ted Price, a neuroscience professor and one of the paper's authors, said in a statement. "I hope by then that we are designing clinical trials better considering sex as a biological variable, and that we understand how chronic pain is driven differently in men and women."

[h/t WIRED]

This Course Will Teach You How to Play Guitar Like a Pro for $29

BartekSzewczyk/iStock via Getty Images
BartekSzewczyk/iStock via Getty Images

Be honest: You’ve watched a YouTube video or two in an attempt to learn how to play a song on the guitar. Whether it was through tabs or simply copying whatever you saw on the screen, the fun always ends when friends start throwing out requests for songs you have no idea how to play. So how about you actually learn how to play guitar for real this time?

It’s now possible to learn guitar from home with the Ultimate Beginner to Expert Guitar Lessons Bundle, which is currently on sale for $29. Grab that Gibson, Fender, or whatever you have handy, and learn to strum rhythms from scratch.

The strumming course will teach you how to count beats and rests to turn your hands and fingers into the perfect accompaniment for your own voice or other musicians. Then, you can take things a step further and learn advanced jamming and soloing to riff anytime, anywhere. This course will teach you to improvise across various chords and progressions so you can jump into any jam with something original. You’ll also have the chance to dive deep into the major guitar genres of bluegrass, blues, and jazz. Lessons in jam etiquette, genre history, and how to read music will separate you from a novice player.

This bundle also includes courses in ear training so you can properly identify any relative note, interval, or pitch. That way, you can play along with any song when it comes on, or even understand how to modify it into the key you’d prefer. And when the time comes to perform, be prepared with skilled hammer-ons, pull-offs, slides, bends, trills, vibrato, and fret-tapping. Not only will you learn the basic foundations of guitar, you’ll ultimately be able to develop your own style with the help of these lessons.

The Ultimate Beginner to Expert Guitar Lessons Bundle is discounted for a limited time. Act on this $29 offer now to work on those fingertip calluses and play like a pro.

 

The Ultimate Beginner to Expert Guitar Lessons Bundle - $29

See Deal


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The Right Way to Clean Your Face Mask

Properly cleaning your face mask is important to keep it free of infectious material.
Properly cleaning your face mask is important to keep it free of infectious material.
mikography/iStock via Getty Images

In an effort to slow the transmission of coronavirus in public settings, health officials are advising that people unable to practice social distancing wear a cloth face mask. While not as effective at filtering respiratory droplets as medical-grade masks, cloth masks are still recommended as a practical preventative step.

Like all apparel, masks get dirty. They absorb sweat and germs, and they need to be cleaned. But how?

According to National Geographic, the best way to clean a cloth face mask is to take the same approach as the rest of your laundry—toss it in the washer. Laundry detergent is effective against coronavirus because the pathogen is encased in a layer of oily lipids and proteins. Detergents and hand soaps contain surfactants, which reduce the surface tension of the fatty layer. The surfactant molecule is attracted to oil and grease on one end and water on the other. The end that disrupts the oil bursts the coronavirus envelope apart. Tiny pods of surfactant called micelles trap and wash the remnants away. It’s this activity, not the water temperature, that kills the virus, though using a higher dryer temperature can destroy most microorganisms that might be lingering.

Bear in mind there’s a recommended way to take off your mask. Make sure your hands are clean, then pull it off using the straps behind your ears. This avoids contaminating the mask—and your face—with any pathogens that might be on your hands.

Medical-grade masks are trickier, as they’re intended to be used only once and can’t stand up to a wash cycle. If you have an N95 or paper mask, you can set it aside for several days, at which point the virus is likely to become inactive. But keep in mind that health officials still aren’t entirely sure how long coronavirus can persist on surfaces, and it’s possible for a mask to collect particles over time, increasing the viral load.

But what about the rest of your clothes? Experts say not to worry so much about disrobing the minute you get home. The coronavirus likes moisture and dries out quickly on fabrics. You need to be careful with the material covering your face, but the rest of your outfit can wait until your regularly scheduled laundry appointment.

[h/t National Geographic]