Does Having Allergies Mean That You Have A Decreased Immunity?

iStock.com/PeopleImages
iStock.com/PeopleImages

Tirumalai Kamala:

No, allergy isn't a sign of decreased immunity. It is a specific type of immune dysregulation. Autoimmunity, inflammatory disorders such as IBS and IBD, and even cancer are examples of other types of immune dysregulation.

Quality and target of immune responses and not their strength is the core issue in allergy. Let's see how.

—Allergens—substances known to induce allergy—are common. Some such as house dust mite and pollen are even ubiquitous.
—Everyone is exposed to allergens yet only a relative handful are clinically diagnosed with allergy.
—Thus allergens don't inherently trigger allergy. They can but only in those predisposed to allergy, not in everyone.
—Each allergic person makes pathological immune responses to not all but to only one or a few structurally related allergens while the non-allergic don't.
—Those diagnosed with allergy aren't necessarily more susceptible to other diseases.

If the immune response of each allergic person is selectively distorted when responding to specific allergens, what makes someone allergic? Obviously a mix of genetic and environmental factors.

[The] thing is allergy prevalence has spiked in recent decades, especially in developed countries, [which is] too short a time period for purely genetic mutation-based changes to be the sole cause, since that would take multiple generations to have such a population-wide effect. That tilts the balance towards environmental change, but what specifically?

Starting in the 1960s, epidemiologists began reporting a link between infections and allergy—[the] more infections in childhood, [the] less the allergy risk [this is called hygiene hypothesis]. Back then, microbiota weren't even a consideration but now we have learned better, so the hygiene hypothesis has expanded to include them.

Essentially, the idea is that the current Western style of living that rapidly developed over the 20th century fundamentally and dramatically reduced lifetime, and, crucially, early life exposure to environmental microorganisms, many of which would have normally become part of an individual's gut microbiota after they were born.

How could gut microbiota composition changes lead to selective allergies in specific individuals? Genetic predisposition should be taken as a given. However, natural history suggests that such predisposition transitioned to a full fledged clinical condition much more rarely in times past.

Let's briefly consider how that equation might have fundamentally changed in recent times. Consider indoor sanitation, piped chlorinated water, C-sections, milk formula, ultra-processed foods, lack of regular contact with farm animals (as a surrogate for nature) and profligate, ubiquitous, even excessive use of antimicrobial products such as antibiotics, to name just a few important factors.

Though some of these were beneficial in their own way, epidemiological data now suggests that such innovations in living conditions also disrupted the intimate association with the natural world that had been the norm for human societies since time immemorial. In the process such dramatic changes appear to have profoundly reduced human gut microbiota diversity among many, mostly in developed countries.

Unbeknownst to us, an epidemic of absence*, as Moises Velasquez-Manoff evocatively puts it, has thus been invisibly taking place across many human societies over the 20th century in lock-step with specific changes in living standards.

Such sudden and profound reduction in gut microbiota diversity thus emerges as the trigger that flips the normally hidden predisposition in some into clinically overt allergy. Actual mechanics of the process remain the subject of active research.

We (my colleague and I) propose a novel predictive mechanism for how disruption of regulatory T cell** function serves as the decisive and non-negotiable link between loss of specific microbiota and inflammatory disorders such as allergies. Time (and supporting data) will tell if we are right.

* An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases Reprint, Moises Velasquez-Manoff

** a small indispensable subset of CD4+ T cells.

This post originally appeared on Quora. Click here to view.

This Smart Accessory Converts Your Instant Pot Into an Air Fryer

Amazon
Amazon

If you can make a recipe in a slow cooker, Dutch oven, or rice cooker, you can likely adapt it for an Instant Pot. Now, this all-in-one cooker can be converted into an air fryer with one handy accessory.

This Instant Pot air fryer lid—currently available on Amazon for $80—adds six new cooking functions to your 6-quart Instant Pot. You can select the air fry setting to get food hot and crispy fast, using as little as 2 tablespoons of oil. Other options include roast, bake, broil, dehydrate, and reheat.

Many dishes you would prepare in the oven or on the stovetop can be made in your Instant Pot when you switch out the lids. Chicken wings, French fries, and onion rings are just a few of the possibilities mentioned in the product description. And if you're used to frying being a hot, arduous process, this lid works without consuming a ton of energy or heating up your kitchen.

The lid comes with a multi-level air fry basket, a broiling and dehydrating tray, and a protective pad and storage cover. Check it out on Amazon.

For more clever ways to use your Instant Pot, take a look at these recipes.

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What Do Pets See When They Watch Television?

This dog would like to turn off Netflix's autoplay feature.
This dog would like to turn off Netflix's autoplay feature.
Amatore/iStock via Getty Images

In 2012, a television commercial aired in the UK for Bakers dog food that was conceived and produced specifically to attract the attention of dogs. The spot used high-frequency sounds that are inaudible to human ears. In theory, the dog would be so captivated by the advertisement that owners would take note and perhaps purchase Bakers for their next meal.

This didn’t quite work. Many dogs failed to react at all, proving that when it comes to television ads, humans may be more impressionable than canines.

While pets may not be so easily manipulated, they still find the television screen interesting, sometimes reacting to other dogs, animals, sounds, or images. But what is a dog really seeing when they tune in?

When it comes to color, television is no different from reality for a dog. They have dichromatic vision, which means they see the world through the range of two primary colors, yellow and blue. (Humans have trichromatic vision, able to see the full color spectrum.) Cone cells in canine eyes are also believed to blur their sight to a degree. More importantly, dogs process the frame rate, or “flicker fusion frequency,” of screens differently than people. Humans can detect movement at between 16 and 20 frames per second. Dogs need 70 frames per second or more. If they’re looking at an older television, it might resemble a flip book or even a strobe light effect to them. (Modern sets have a faster frame rate, which is why dogs might be more interested in your high-definition television.)

That helps explain the visuals. What about the content? Typically, dogs will react to the same things that would draw their attention in a room—barking, squeaking toys, or commands. In a study published in Animal Cognition in 2013, nine dogs were observed to see if they could pick out the face of another dog—regardless of breed—on a computer screen instead of another animal or a person. The dogs were rewarded with treats with a successful choice. Though the sample size was small, it indicated dogs can recognize other dogs on a screen. (Which you likely already knew if you’ve ever observed your dog suddenly on alert when a canine appears on camera.)

If your dog used to get excited by another dog on television but has since lost interest, it’s possible they simply became desensitized to their appearance, realizing the image in front of them isn’t going to move out of the boundaries of the monitor.

Content unrelated to dogs might not be of much interest. In a 2017 study published in the International Journal of Human-Computer Studies, dogs presented with three different viewing screens didn’t exhibit any particular preference for one over the other. If they were shown three screens at one time, they seemed uninterested in watching anything at all.

The study also noted that dogs had a limited television attention span. Rather than mimic the binge-watching habits of humans, dogs prefer to glance at a screen for a few seconds at a time. But that behavior could also be breed-specific. Dogs bred for hunting might be interested in moving objects, while dogs that rely more on smell might be indifferent.

And what about cats? In a study published in Applied Animal Behaviour Science in 2008, 125 shelter cats were given a television to view for up to three hours a day. The cats were split into five groups and given a variety of programming to watch, from humans to footage of prey to a blank screen. On average, cats spent just 6.1 percent of the observation time watching the screen. When they did, it was mostly to focus on the prey.

Because cats may react to images of birds and rodents on television, owners should avoid letting them watch unattended. You can also secure the set to a wall to make sure they don’t knock it down.

For the most part, dogs and cats are far more interested in what’s going on in the real world compared to what's on TV. We could probably take a lesson from their limited screen time.