8 Cures That Did More Harm Than Good

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iStock.com/powerofforever

No one likes to be sick or suffering. But in the course of trying to find new cures for medical problems, or perceived medical problems, we’ve stumbled more than a few times. Most of the time, treatments simply didn't work and were no more harmful than what they were meant to “cure.” Sometimes, though, the medicine was even worse than the condition itself.

1. RAW MEAT AND HOG FAT FOR A RABIES BITE

To his credit, Pliny the Elder discounted many purely magical folk cures in his Natural Histories (not to mention writing entire chapters against the eating of infant brains). He was also a proponent of several treatments which we now know to have some merit, such as aloe vera to dress burns.

Still, his advice was often more questionable than credible. His cures for bites from a mad (rabid) human or dog were the same—raw veal or she-goat dung placed over the wound for no less than four days, while the patient takes only lime and hog’s fat internally. If this doesn’t sound so bad, imagine eating nothing but antacids and lard, while having an open wound get more and more infected. If you weren’t dead by the time the rabies actually manifested, you probably wished you were.

2. SMACKING A BIBLE ON A GANGLION CYST

Hit them with a book. A heavy book. The use of Bibles to cure ganglion cysts provided the colloquial terms for this benign lump on the hand or wrist: Bible cysts, Gideon’s disease, or Bible bumps.

Really, you shouldn’t do this, however. While in some circumstances the lump may disappear or be reabsorbed after being thwacked, this method of treatment is second only to puncturing them in an unsterile environment when it comes to causing recurrence and complications. Most ganglion cysts cause no complications on their own, and many will disappear after a few months if left alone [PDF].

3. WHIPPING FOR "DRAPETOMANIA" OR "DYSAETHESIA AETHIOPICA"

Drapetomania and dysaethesia aethiopica were two different but related “conditions” that one Samuel Cartwright saw as prevalent among slaves during the mid-19th century. Drapetomania supposedly caused an “insanity” that drove slaves to run away, while dysaethesia aethiopica caused “partial numbness of the skin,” and “great hebetude” (mental dullness and lethargy).

To cure either condition, you needed only to whip the patient. The concept caught on in the South, as it lent an air of science and self-justification to slave owners—Cartwright’s work suggested that the only moral thing to do was to keep slaves in their place for their own good, lest they become afflicted with one of these conditions (he noted how “common” dysaethesia aethiopica was among “Free Negros”). Of course, this quackery was not hard to spot by his contemporaries outside of the South. Frederick Douglass once sarcastically remarked that, since white indentured servants run away, too, “drapetomania” was probably a European condition that had been introduced to Africans by white slave traders.

4. SMOKING FOR ASTHMA

Smoke a cigarette! Not a tobacco cigarette (though those were advertised as “healthy” for decades), but an herbal remedy. While a few components of these cigarettes may have caused a degree of temporary relief for those with bronchitis or asthma, the long-term effects of smoking anything are known to be detrimental, especially to those whose lungs are already diseased. 

Long-term effects aside, many of the “asthma cigarettes” contained ingredients that were immediately and seriously harmful. Several brands boasted adding arsenic to their papers. Two of the staple ingredients for many companies were stramonium, an extract from the deadly Jimson weed (Datura stramonium) plant, and belladonna, extracted from deadly nightshade (Atropa belladonna).

5. HEROIN TO CURE A MORPHINE HABIT

“Morphinism,” or morphine addiction, was perceived to be such a pervasive habit, and seen as such a scourge in polite society, that quack cures and treatments were easy to convince people to try, and rarely got reported or noticed when they didn’t work.

While unlabeled patent medicines in the U.S. were forced to reveal their ingredients after the passage of the 1906 Pure Food and Drug Act, many dangerous concoctions were still sold and advertised falsely. The tale of Bayer’s Heroin being used to “cure” morphine addiction (with a much more addictive and refined opiate) is pretty well-known, but it never caught on as much as Habitina (also known as Morphina-Cura) did. Habitina became known for its paid testimonials and dodgy advertising claims (“Non-Addictive! Cures the morphine habit!”), and was one of the most significant examples of the shortcomings of the Pure Food and Drug Act.

Habitina not only didn't give the patient a cure, it combined the worst sides of the pharmaceutical industry into one bottle—its main ingredients were morphine sulfate (does it count as a cure if you call the same drug by a different name?), heroin, and caffeine.

6. RADIUM TO PREVENT INSANITY AND OLD AGE

“The Radium Water Worked Fine Until His Jaw Came Off” has to be one of the best Wall Street Journal headlines of all time. The “radium water” in question was called Radithor, and the jaw in question belonged to one Eben Byers: industrialist, socialite, and amateur golf champion.

Radium and radiation were all the rage around the turn of the 20th century. People who went to natural hot springs seemed “invigorated and renewed,” and scientists noted that many of these natural springs were high in naturally-occurring radon. The radon seemed to be to water what oxygen was to air; without it, water was “dead.” Looking to profit off of this discovery, companies first bottled water directly from the springs, and later produced “invigorating” crocks (containing internal radon discs or coatings) to irradiate water. Just fill the crock before you go to sleep, and have healthy, stimulating water all day long!

Unfortunately for those who consumed the radon, the radiation in the water did the opposite of what it was supposed to do. Eben Byers bought into the claims, and drank three bottles of Radithor a day, beginning in 1930. In 1932, his teeth began to fall out, holes began to appear in his jaw, and he became generally unwell. He was dying of aggressive cancer brought on by the radon (not radiation poisoning, as is commonly believed, but still directly attributable to the Radithor). He died at age 51 and was buried in a lead-lined coffin. His was one of the cases used to substantially increase the FDA’s ability to regulate medical claims, when the 1938 Food, Drug, and Cosmetic Act passed.

7. GOAT GLANDS TO CURE IMPOTENCE

Some people will do anything to get their “potency” back, and there are plenty of people out there who are willing to take advantage of that. John R. Brinkley was one of the myriad snake-oil salesmen at the turn of the century, but a medical degree bought from a diploma mill led the now-“Dr.” Brinkley to pursue grander matters.

Early on in Brinkley’s career, Bill Stittsworth, a farmer with “no lead in his pencil, no powder in his pistol” consulted him. The story goes that Brinkley jokingly remarked that it was too bad the farmer didn’t have the glands of the frisky billy goats outside, but Stittsworth, taking Brinkley seriously, said “Doctor, I want you to transplant [the goat glands] into me.” The doctor did as much, and nine months later, Bill Stittsworth’s wife reportedly bore a son, appropriately named “Billy.”

Seeing the potential to profit from this venture, John Brinkley set up a major advertising campaign centered on “Billy,” and “goat-gland transplantation” took off. Over 16,000 men had their scrotums cut open and tissue plugs from the goat testicles inserted. In the best-case scenario, the men’s bodies simply broke down the goat tissues and healed up, but many patients weren’t so lucky.

The fact that Brinkley was a mediocre medical man at best led to dozens of deaths that were directly attributable to his operation, but hundreds more are believed to have been killed by infection, gangrene, or surgical mishaps. Those deaths also helped lead to the revocation of Brinkley’s license to practice medicine in Kansas in 1930. Unfortunately for the easily swayed, he remained in the goat-gland business for another decade in Texas.

8. THALIDOMIDE TO CURE MORNING SICKNESS AND SLEEPLESSNESS

The 1950s were an era of innovation, new discoveries, and excitement about the potential that science had to improve our lives. Drug companies were thriving on this outlook, and developing cures for even the smallest of ailments. Sleeplessness was a major problem, according to contemporary doctors, but the only reliable sedatives were barbiturates, which had a host of known addiction problems and side effects.

In 1957, the German drug company Grunenthal developed a non-barbiturate, non-habit-forming sleep aid called Thalidomide. It was sold over the counter, and touted as “safe for everyone.” Grunenthal’s adverts boasted that they could not find a dose high enough to kill a rat. By 1960, its sales in Europe and the Commonwealth countries nearly matched that of aspirin. Down in Australia, Dr. William McBride noticed that women who took the drug were often alleviated of their morning sickness, and sales boomed even higher.

It was too good to be true. By 1961, babies were beginning to be born to mothers who had taken Thalidomide in early pregnancy. Many of them had shortened or absent “flipper” limbs. Dr. McBride realized his mistake, and did everything he could to retract his endorsements of the drug, but it was too late for over 12,000 infants. By 1961, the drug was pulled off the market, but Grunenthal offered no recompense or statement regarding its inadequate testing and irresponsible promotion.

Interestingly, the story of Thalidomide had a rather different turn in the United States. Though it technically passed the requirements of the FDA testing authority at the time, FDA inspector Frances Kelsey would not approve its distribution. Ms. Kelsey felt the company provided insufficient data on the efficacy and safety of the drug on its applications, and despite pressure from pharmaceutical companies and other FDA supervisors, she refused to budge on the issue. President John F. Kennedy eventually heralded her as a heroine, after the scandal of the “Thalidomide babies” broke overseas.

This incident further strengthened the testing requirements of the FDA, and greatly increased the oversight and regulation of equivalent organizations in other countries. Interestingly, Thalidomide is once again being used as a drug, albeit with extreme restrictions on who can take it. It’s a chemotherapeutic agent that has significant benefits for multiple myeloma patients, and it has also been used in the treatment of Hansen’s disease (leprosy). Patients on the drug must have pregnancy tests and use reliable contraception if they are sexually active, and must not become pregnant within 4 weeks of coming off the drug.

This story first ran in 2013.

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5 Facts About Kawasaki Disease

Ridofranz, iStock via Getty Images
Ridofranz, iStock via Getty Images

While most pediatric COVID-19 cases are mild, the disease has been tied to a serious new syndrome in kids. In recent weeks, dozens of children who tested positive for COVID-19 antibodies have exhibited symptoms like rash, fever, diarrhea, and swollen hands and feet—all signs similar to a rare condition called Kawasaki disease. Like Kawasaki disease, the mystery illness, officially known as pediatric multi-system inflammatory syndrome (PIMS), can lead to severe heart issues. In New York, three children have died from it.

Medical experts still aren’t sure how this condition develops, or how it’s related to COVID-19. Here are five things we do know about Kawasaki disease, the syndrome it resembles.

1. Symptoms of Kawasaki disease appear in phases.

When patients first contract Kawasaki disease, the most serious symptom is a high fever that lasts five days or more. Other diagnostic signs that appear in this first stage include chapped lips, bloodshot eyes, sore throat, swollen hands and feet, and a rash covering the back, limbs, belly, and groin. These symptoms are the result of inflammation in the arteries, veins, capillaries, and lymph nodes.

After experiencing a fever for about two weeks, patients may enter the second stage of the disease. This phase is characterized by diarrhea, vomiting, joint pain, and temporary hearing loss. Peeling skin on the hands and feet is another symptom, with dead skin sometimes coming off the extremities in layers.

The third phase is known as the convalescent phase, and it comes about four weeks after the fever first develops. During this period, which can last a couple of weeks, patients gradually recover and their symptoms improve.

2. Kawasaki disease can have deadly complications.

Most children who get Kawasaki disease fully recover, and recovery rates are even higher when the disease is caught early. But in some cases, the illness has dangerous effects on the cardiovascular system. The inflammation that characterizes the disease can weaken artery walls, resulting in rare cases of heart disease and heart attacks in children. Heart problems afflict about a quarter of Kawasaki disease patients who didn’t receive early treatment for the condition. Of these untreated cases, roughly 2 to 3 percent are fatal.

3. Kawasaki disease is uncommon.

Kawasaki disease is rare, effecting roughly 4200 children in the U.S. annually. The syndrome is almost exclusive to kids, with most cases occurring in patients younger than 5 years old. It’s 1.5 times more common in boys, so sex may factor into who gets it. Ethnicity is another possible component: Kawasaki disease rates are 10 to 20 times higher in East Asian countries like Korea and Japan than in the U.S.

4. Kawasaki disease is often treated with an over-the-counter drug.

One of the primary treatments for Kawasaki disease is aspirin. The anti-inflammatory drug can help relieve pain, reduce fever, and prevent blood clots in kids with the condition. Aspirin shouldn’t be taken by children for other types of fever or pain, though, due to the risk of a serious condition called Reye's syndrome. Kawasaki disease is the rare instance when aspirin is given to kids, and even in these cases, it should only be taken under the supervision of a doctor.

The other main treatment for the disease is intravenous immunoglobulin, or IVIG. Immunoglobulin is a solution of antibodies from healthy donors that helps boost the patient's immune system to fight disease. It’s administered through the patient’s vein, and if given early enough, it can reduce symptoms within 36 hours.

5. COVID-19 may trigger Kawasaki disease, but it's too soon to tell.

Doctors are unclear on what causes Kawasaki disease. One theory is that antigens found in some viruses can trigger a hyper-inflammatory response in children who are genetically susceptible. This is similar to what's being observed in the new pediatric multi-system inflammatory syndrome, which is possibly related to COVID-19. "We think patients were exposed to the SARS-CoV-2 virus, they may or may not have had some symptoms, and later on there was a delayed reaction," Michael Portman, pediatric cardiologist and director of the Kawasaki Disease Clinic at Seattle Children’s, says of the recent PIMS cases. "There was a hyper-inflammatory response launched by the body against the viral antigen, so that fits with the main hypothesis for Kawasaki disease."

More research still needs to be done to understand the relationship between PIMS and COVID-19. "It's a little bit early to make a direct link, but it seems plausible that the new coronavirus does trigger an immune response that could result in Kawasaki disease, or a different spectrum of the disease, or even a separate disease that we're calling PIMS," Portman tells Mental Floss.

It's also too early to say definitively that PIMS and Kawasaki disease are the same thing, but to experts who have studied the latter, the new syndrome looks very familiar. "It is very difficult to separate the two," Portman says. "They are very, very similar, and it's going to take quite a bit of research to determine if they're different."