The First Shot to Stop Chronic Migraines Just Secured FDA Approval

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iStock

Migraine sufferers unhappy with current treatments will soon have a new option to consider. Aimovig, a monthly shot, just received approval from the Food and Drug Administration and is now eligible for sale, CBS News reports. The shot is the first FDA-approved drug of its kind designed to stop migraines before they start and prevent them over the long term.

As Mental Floss reported back in February before the drug was cleared, the new therapy is designed to tackle a key component of migraine pain. Past studies have shown that levels of a protein called calcitonin gene–related peptide (CGRP) spike in chronic sufferers when they're experiencing the splitting headaches. In clinical trials, patients injected with the CGRP-blocking medicine in Aimovig saw their monthly migraine episodes cut in half (from eight a month to just four). Some subjects reported no migraines at all in the month after receiving the shot.

Researchers have only recently begun to untangle the mysteries of chronic migraine treatment. Until this point, some of the best options patients had were medications that weren't even developed to treat the condition, like antidepressants, epilepsy drugs, and Botox. In addition to yielding spotty results, many of these treatments also come with severe side effects. The most serious side effects observed in the Aimovig studies were colds and respiratory infections.

Monthly Aimovig shots will cost $6900 a year without insurance. Now that the drug has been approved, a flood of competitors will likely follow: This year alone, three similar shots are expected to receive FDA clearance.

[h/t CBS News]

Here’s What You Need to Know About the New Coronavirus

jarun011/iStock via Getty Images
jarun011/iStock via Getty Images

This morning, the Centers for Disease Control and Prevention (CDC) confirmed the second case of the recently discovered coronavirus in the U.S. Find out what it is, where it is, how to avoid it, and all the other need-to-know information about the illness below.

What is the new coronavirus?

Coronaviruses are a group of viruses named for the crown-shaped spikes that cover their surfaces (corona is the Latin word for crown). According to the CDC, human coronaviruses can cause upper-respiratory tract illnesses, including the common cold, and can sometimes lead to more severe lower-respiratory tract issues like pneumonia or bronchitis.

Because this latest coronavirus, 2019-nCoV, is so new, health officials are currently trying to figure out how it works and how to treat it. It’s not the first time a potent new coronavirus has caused an international outbreak: SARS-CoV originated in Asia and spread to more than two dozen countries in 2003, and MERS-CoV first infected people in Saudi Arabia before spreading across the globe in 2012.

Where is the coronavirus outbreak happening?

The majority of cases are in China, which counts more than 800 confirmed diagnoses. Most are in Wuhan, a city in China’s Hubei province where 2019-nCoV was first detected last month. Additional cases have been reported in South Korea, Japan, Singapore, Hong Kong, Macao, Taiwan, Thailand, and Vietnam.

The CDC has confirmed two U.S. cases—a man in his thirties outside Seattle, and a 60-year-old woman in Chicago—both of whom had recently returned from trips to Wuhan. A CDC official said another 63 potential cases are being investigated in 22 states, and airports in New York, Chicago, Los Angeles, Atlanta, and San Francisco are conducting health screenings on passengers arriving from China.

Chinese officials have shut down transportation to and from Wuhan. Tourist spots like Beijing’s Forbidden City, Shanghai Disneyland, and a portion of the Great Wall are also closed temporarily.

What are the symptoms of the new coronavirus?

Symptoms are similar to those caused by a cold or the flu, including fever, dry cough, and breathing difficulty. The New York Times reported that as of Friday morning, 25 people in China have died from the virus, and most of them were older men with preexisting health conditions like cirrhosis, diabetes, and Parkinson’s disease.

How does the new coronavirus spread?

Because most of the early cases of 2019-nCoV were traced back to a seafood and meat market in Wuhan, health officials think the virus originally spread from infected animals to humans, but it’s now being transmitted from person to person.

Though scientists are still studying exactly how that happens, the leading theory is that it travels in tiny droplets of fluid from the respiratory tract when a person coughs or sneezes.

How do you avoid the new coronavirus?

The CDC is warning everyone to avoid any nonessential trips to Wuhan, and to avoid animals or sick people if you’re traveling elsewhere in China. If you’ve been to China in the last two weeks and experience any of the symptoms listed above, you should seek medical attention immediately—and you should call the doctor’s office or emergency room beforehand to let them know you’re coming.

Otherwise, simply stick to the precautions you’d normally take when trying to stay healthy: Wash your hands often with soap and water, cover your nose and mouth when coughing or sneezing, stay away from sick people, and thoroughly cook any meat or eggs before eating them.

Should you be worried about the new coronavirus?

The global health community is taking 2019-nCoV seriously in order to curb the outbreak as quickly as possible, but you shouldn’t panic. The CDC maintains that it’s a low-risk situation in the U.S., and public health officials are echoing that message.

“We don’t want the American public to be worried about this, because their risk is low,” Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told USA Today.

[h/t USA Today]

10 Best U.S. Cities for Reducing Stress

Anaheim, California's Paradise Pier.
Anaheim, California's Paradise Pier.
Kirkikis/iStock via Getty Images

Looking to reduce your stress level? You might want to consider moving to Anaheim, California. Homeowner website House Method analyzed data from America’s largest 100 cities in order to determine the best—and worst—cities for managing your stress level.

The company looked at the same five factors across all 100 cities: commute time, mental health counselors per capita, the percentage of people who exercise regularly, walkability (specifically: to a park), and the number of yoga instructors and classes. Once all the data was tallied, Anaheim, California ended up in the top spot with an overall score of 38.5.

"The city has beautiful weather, lots of sunshine, and Disneyland. How could you be stressed when Mickey lives right down the road?," House Method’s senior editor and researcher David Cusick wrote of the results. "While Anaheim didn’t have the best score for commute time, it did rank number one for the city with the most mental health counselors per capita and has a very high percentage of people who like to exercise frequently."

California did well overall; four of the survey’s top 10 cities were located in The Golden State: Oakland came in second, Irvine came in fourth, and San Francisco came in fifth (despite its high housing costs). Seattle and Spokane, Washington—which came in eighth and tenth, respectively—tipped the scales in the west coast’s favor. Here are the 10 best cities for reducing stress:

  1. Anaheim, CA
  2. Oakland, CA
  3. Jersey City, NJ
  4. Irvine, CA
  5. San Francisco, CA
  6. Minneapolis, MN
  7. Madison, WI
  8. Seattle, WA
  9. Aurora, CO
  10. Spokane, WA

On the other end of the rankings were America’s worst cities for reducing stress, with Laredo, Texas taking the title as the very worst. “Laredo ranked last for the amount of mental health counselors per capita, percentage of people who exercise, and the amount of yoga instructors/classes,” Cusick wrote. “Filling out the bottom five cities are Bakersfield, California (96); Indianapolis, Indiana (97); San Antonio, Texas (98); and Jacksonville, Florida (99).”

For the full list of city rankings, visit House Method.

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