Good news for hopeless romantics and the perpetually dismayed: All that sighing is good for you. In fact, you’d die without it. Scientists have now pinpointed the region in the brain that transforms normal breathing into a life-giving sigh. They published their findings this week in the journal Nature.
Let’s start with the mechanics. Physiologically speaking, sighing is a way of keeping your lungs inflated. “A sigh is a deep breath, but not a voluntary deep breath,” study co-author Jack Feldman said in a press release. “It starts out as a normal breath, but before you exhale, you take a second breath on top of it.” Whether you realize it or not, you do this about 12 times an hour, and even more than that when you’re stressed or anxious. And it’s a good thing you do. “If you don’t sigh every five minutes of so, the alveoli will slowly collapse, causing lung failure,” Feldman said. “That’s why patients in early iron lungs had such problems, because they never sighed.” The machines had not been programmed to give patients regular deep, lung-filling breaths.
One group of researchers sifted through nearly 19,000 gene expression patterns in the active brains of mice, looking for the root of the sigh reflex. It was much smaller than they expected: just one little bundle of 200 cells in the brain stem, releasing one of two molecules called peptides. They shared their data with Feldman’s lab, and together the team found another set of 200 cells on the peptide receiving end.
A mouse's sigh clusters. Image credit: Stanford/Krasnow Lab
When the scientists prevented one peptide from reaching its goal, the rate of the mice’s sighing was cut in half. Blocking both peptides caused the mice to stop sighing altogether. “Unlike a pacemaker that regulates only how fast we breathe, the brain’s breathing center also controls the type of breath we take,” co-author Mark Krasnow noted in the press release. “It’s made up of small numbers of different kinds of neurons. Each functions like a button that turns on a different type of breath. One button programs regular breaths, another sighs, and the others could be for yawns, sniffs, coughs, and maybe even laughs and cries.”
It’s highly unusual for such small clusters of neurons to have so much power, Feldman said. “Sighing appears to be regulated by the fewest number of neurons we have seen linked to a fundamental human behavior.” The team’s findings may someday lead to treatment for people with diseases that limit their breathing. “These molecular pathways are critical regulators of sighing, and define the core of a sigh-control circuit,” Krasnow said. “It may now be possible to find drugs that target these pathways to control sighing.”
Rotavirus—from the Latin rota, for "wheel"—is named for the wheel-like appearance of its particles.
Dr_Microbe/iStock via Getty Images
As you may already know, the corona in coronavirus has no relation to a certain refreshing beer often served with a slice of lime. Corōna means “crown” in Latin—and Spanish and Italian, too—and virologists chose it in 1968 to describe the group of viruses characterized by crown-like spikes that protrude from their surfaces.
So how do other viruses and diseases get their names? Based on the infographic below, created by Adam Aleksic for his website, The Etymology Nerd, there isn’t just one way. Some, like the coronavirus, are named for how they look under a microscope. The rota in rotavirus, for example, which means “wheel” in Latin, reflects the virus’s wheel-like appearance when viewed beneath an electron microscope.
Others are named after the locations where they were discovered or studied. In 1947, scientists named a newly identified mosquito-borne virus after Uganda’s Zika Forest. In 1977, Yale researchers investigating a string of pediatric arthritis cases in the town of Lyme, Connecticut, started referring to the illness as “Lyme arthritis.” Later, the name was modified to “Lyme disease” when scientists realized patients were exhibiting other symptoms, too.
Still others are characterized by the symptoms they cause. People with tetanus—from the Greek tetanos, for “tension”—usually experience muscle stiffness, and the skin of yellow fever sufferers often takes on a yellow tint due to jaundice.
Find out the origins of malaria, measles, and more below. And follow The Etymology Nerd on Instagram for more fascinating etymological explanations.
Unsurprisingly, there's a lot of Latin in this infographic.
Chef Gordon Ramsay is just one of the professionals lending their knowledge to a MasterClass course.
Franco Origlia/Getty Images
Although binge-watching Netflix is always a great way to kill a few hours, you might want to shake it up and do something a little more substantial with your free time. That’s where MasterClass comes in. A subscription package that features over 80 virtual courses in a wide range of subjects, MasterClass can help you explore exciting new subjects or improve your knowledge in an area you’re already familiar with. And all the classes are taught by highly recognizable experts in their fields, so you can be confident that the lessons you’re learning are solid (that Martin Scorsese probably knows a thing or two about filmmaking, after all).
The courses themselves are broken up into individual lessons that are only around 10 minutes long, so fitting them into your schedule is as easy as becoming a professional chess player (or it will be, once you’ve finished the course). MasterClass is priced at $15 a month for unlimited classes or at $90 per course, and you can sign up here.
So whether you want to become the next great young adult novelist or an expert bartender, MasterClass has something for everyone. Check out a few highlights from the course list.
Gordon Ramsay, known for his sharp demeanor and high expectations in the kitchen, is an international chef, restaurateur, and television host who’s nothing short of legendary. And in his MasterClass series, he’ll teach you to become a legend, too. This series features the softer side of Ramsay, who teaches you knife techniques, seasoning tricks, kitchen layout, and much more. And, for anyone ready to level up, he also offers Cooking II: Restaurant Recipes in the Kitchen.
If you’re ready to become an award-winning bartender—or just make a decent martini at home—look no further than this 17-lesson course with master mixologists Lynnette Marrero and Ryan Chetiyawardana. You’ll not only learn to craft the perfect cocktail, but also how to safely incorporate raw eggs into drinks, make complementary drink “seasonings,” and discover the best liquor to pair with food (who knew that whiskey and blue cheese were a match made in heaven?). A good drink has the power to bring people together, and after this course, you’ll be the go-to guru for any dinner party.
After you’re through with R.L. Stine’s class on writing for young adults, you may just become the next sultan of the Scholastic Book Fair. According to his website, Stine has written over 330 books over the course of his career, and he’s provided thrills and chills to millions of readers with his beloved Goosebumps and Fear Street series. Now, he’ll teach you some of his favorite tricks of the trade, like why you should always start with the ending (so you can focus on fooling your reader for the entire book) and how writing from personal experience makes for a more sincere scare. This masterclass will help you perfect the art of scary storytelling and overcome any fears you might have about putting your own experiences on the page.
Dr. Jane Goodall is best known for her groundbreaking work with chimpanzees and gorillas, but she’s more than just a scientist—she’s an environmental activist and conservationist who wants to ensure that animal habitats are preserved for years to come. In this course, Dr. Goodall will share some of the conservation lessons she’s learned as a scientist, identify the central problems facing our planet today, and share effective methods for creating change. As she says, one of the best ways to confront environmental issues is by “telling stories, meeting with people, listening to them, and then finding a way to reach the heart.” This course will show you how.
Garry Kasparov, a chess grandmaster and world chess champion, will help you dust off your old chessboard and learn to play the game like it’s an art form. This 29-lesson class starts with the basics and gets more complex the further you get into the course. Using the tactics he’s curated throughout his career, Kasparov will show you how to approach chess with a strategist's mindset, including the basics of openings, interference plans, and endgames. This class even features other “students” so you’re not just studying the techniques, but seeing how they play out in real time, too.
One of comedy’s greatest names—and one of film’s most beloved actors—is Steve Martin. The star of film classics such as Father of the Bride and Planes, Trains, and Automobiles, Martin will teach you how to find your comedic voice, develop your persona, and work a crowd so that you’ll never get booed off the stage. And he’ll share his comedic process, which involves more writing and editing than it does practicing in the mirror. This is the perfect class for anyone looking to practice their improv skills or sign up for their first open mic night.
Make your childhood dreams come true with this course from retired astronaut Chris Hadfield, who’s flown two Space Shuttle missions and served as commander of the International Space Station during his 21 years as an astronaut. And in his course, he’ll teach you the intricacies of space exploration, from learning how rockets work to preparing your body for liftoff. Even if you're not planning on leaving the atmosphere (or your couch) anytime soon, this class teaches you what it's like to be an astronaut. And as Hadfield talks about his unique journey to the stars, there's the chance to learn plenty of life and career lessons that you can apply on Earth.
Even if your biggest adventure is going on a walk in your local park, award-winning adventure photographer Jimmy Chin (the face behind documentaries such as Free Solo and Meru) will still teach you how to turn your photographs into works of art. Chin’s class acts as part photography course and part adventure guide, teaching you every step from choosing the right location to editing the final product. You’ll learn how to plan shoots, pack the right gear, and even find clients if you want to go professional. Whether you want to make photography a career or just take the perfect photo of your dog at golden hour, this masterclass will get you feeling comfortable behind the camera and bring some more adventure into your everyday life.
At Mental Floss, we only write about the products we love and want to share with our readers, so all products are chosen independently by our editors. Mental Floss has affiliate relationships with certain retailers and may receive a percentage of any sale made from the links on this page. Prices and availability are accurate as of the time of publication.