15 Useful Facts About Lyme Disease

Stringer/Getty Images
Stringer/Getty Images

As summer nears and you spend more time outdoors in one of the many beautiful natural spots in the United States, be sure to dress for the season—tick season, that is. Some experts say 2017 may be an especially tick-infested year. Deer ticks (Ixodes scapularis) carry a bacteria that causes Lyme disease, an infection from a bacterium that coils waiting in their insect bodies. Lyme-carrying deer ticks are especially prevalent in the upper East Coast, the upper Midwest, northern California, and the Oregon coast. While not every tick carries the bacteria that lead to infection—and some carry other pathogens—it’s best to take precautions to prevent bites, and seek medical attention if you have been bitten. The infection can cause long-lasting damage if not treated early. Here are 15 facts you need to know about Lyme disease.

1. LYME DISEASE IS CAUSED BY COILED BACTERIA.

Lyme disease is caused by the bacterium Borrelia burgdorferi, a spirochete, or tightly coiled bacterium that looks like a tiny spring under a microscope. Spirochetes are very simple, slow-replicating bacteria that require a mammalian or avian host to survive. According to Timothy Sellati, chair of the infectious diseases department at Southern Research, a nonprofit research institution in Birmingham, Alabama, “It takes on the order of 18–20 hours for a single spirochete to divide into two.” That’s incredibly slow, compared to other bacteria like E. coli, which can replicate every 20 minutes. Because Borrelia replicates so slowly, and they don’t reach high numbers, “They do not show up easily in a blood test,” Sellati says.

2. TICKS PREFER A LONG MEAL.

Sellati explains that ticks are very different feeders from mosquitoes, which he calls “hit-and-run feeders.” Ticks will feed over a period of three to five days before they become fully engorged. Female ticks generally only take three “blood meals,” he says, in the duration of their lifespan. They take one blood meal after hatching from their egg into the larval stage, another after they molt into their nymphal stage—the stage where they are most likely to bite you—and a final “big meal” in preparation for laying thousands of eggs. Adult male ticks generally don’t feed, he says.

3. THEY ARE A VIRULENT DISEASE VECTOR …

When an infected tick bites a human, the waiting spirochetes—which live essentially dormant in the tick’s gut until environmental cues such as changes in temperature and oxygen availability awaken them—travel from the tick’s gut to its saliva glands. “From the saliva glands they can literally be spat into the bloodstream that the tick is feeding on,” Sellati says. Once they enter the bloodstream, spirochetes travel to various body tissues, because if they stay too long in the bloodstream, they’ll get killed by their host's immune system. “Once it gets away from site of inoculation, it shows a bias toward joints, heart, central nervous system,” Sellati says.

4. … WHICH LEADS TO INFLAMMATION.

“The bacteria has components that are very effective at eliciting an inflammatory response,” Sellati explains. While Borrelia don’t produce toxins like other bacteria, they do incite inflammation in sensitive parts of the body such as the joints, heart, and brain. “That inflammatory response is important to help kill and clear the spirochetes, but it causes collateral damage as well.”

5. INFECTIONS MAY BEGIN WITH A BULL'S-EYE.

The first symptom to look for in about 80 to 90 percent of Lyme cases is a telltale rash of an infected tick bite, called an erythema migrans (EM) rash, which looks a lot like a red bull's-eye, and usually appears at the site of a tick bite within seven to 14 days, according to the American Lyme Disease Foundation. However, the rash does not appear in every instance of Lyme disease, so if you’re bitten, you should visit a doctor immediately. You may also experience flu-like symptoms or joint pains in the first month after the bite.

6. DON'T WAIT TO GET TREATMENT.

If you don't see the tick bite, and don't treat early symptoms, the spirochetes continue to spread throughout your body and can cause more severe symptoms, including fatigue, stiff or aching neck, tingling or numbness in your extremities, and even paralysis of your face. Even more debilitating symptoms of later-stage Lyme disease can include severe headaches, painful arthritis and swelling of joints, cardiac abnormalities, and central nervous system debilitations leading to cognitive disorders.

7. IF CAUGHT EARLY, IT'S USUALLY HIGHLY TREATABLE …

When the disease is caught in its early stages, and treated with antibiotics, it’s curable, Sellati says. Even later stages of the disease can be treated, but the longer an infection goes untreated, the more severe the symptoms and damage can become.

8. … BUT SOME PATIENTS EXPERIENCE SYMPTOMS FOR MUCH LONGER.

Scientists are not entirely sure why a subset of patients have recurrent symptoms of the illness in the months and even years following treatment, known as post-treatment Lyme disease syndrome. “It’s not clear if there is a persistence of live replicating bacteria in some immune privileged niche where they’re protected from exposure to antibiotics,” Sellati says, or if it’s simply the subsequent inflammation stirred up in the body that refuses to go back to normal. “What drives that is not entirely clear.”

9. YOUR GENETICS MAY DICTATE YOUR TREATMENT.

Sellati’s lab has been exploring whether genetics plays a role in who recovers after treatment and who doesn’t. “We have some evidence that your genetic makeup can actually predispose you to developing post-treatment Lyme disease syndrome," Sellati says, and adds it will require more research. They believe they might be able to isolate genetic markers that will tell doctors if antibiotics alone will work, or if the patient might need additional treatment.

10. FEAR THE ENGORGED TICK (BUT DON'T PANIC).

The good news is, even if a tick bites you, if it isn’t yet fully engorged on your blood, chances are good it hasn’t been there long enough to transmit the spirochetes that lead to infection. However, it’s always better to be safe, and pay attention to any symptoms that occur thereafter. “The sooner you can remove a tick from your body, whether it’s feeding or not, the better. If the tick is feeding for less than 24 hours, the likelihood of being infected with Borellia is significantly reduced,” Sellati says.

11. AREAS WITH MICE HAVE MORE LYME DISEASE.

Wherever you find mice and deer you’re very likely to find ticks as well. In fact, Sellati says, mice in all forms—but especially the white-footed mouse—are what infectious researchers call a “maintenance reservoir.” Sellati says. “They maintain the bacteria in the wild so that new ticks can acquire it.” Since spirochetes tend to stay in the bloodstream of mice much longer than they do in humans, that’s how ticks have such an endless supply of the bacteria. “If you got rid of all the mice in the world, you would either come very close to or significantly reduce the population of Borellia in the environment. You’d have a significant decrease in Lyme,” he emphasizes.

12. YOU CAN TAKE SIMPLE STEPS TO PROTECT YOURSELF.

Wear clothes with the most coverage possible. Spray yourself with anti-tick sprays. But no matter what, always do a tick check after you return from the outdoors just to be safe. And if you start to feel any of the symptoms mentioned earlier within a month of a tick bite, don’t wait to visit your doctor.

13. CHECK YOUR CREVICES.

Ticks are not opposed to biting you wherever they can reach, but they have a preference for your warm, moist crevices, such as armpits, backs of the knee, groin, base of the head, and nape of your neck.

14. SKIP SOME OF THOSE "TIPS" FOR REMOVING TICKS THAT YOU'VE HEARD ABOUT.

No matter how many YouTube tutorials you’ve watched, Sellati recommends that you do not use heat, like a match or a lighter, to burn a tick off. The same goes for “goops” such as petroleum jelly, alcohol, or hand sanitizer. Since the spirochetes are transmitted through tick saliva, Sellati warns, “If you try to do those things, you’re only going to piss the tick off, and a pissed-off tick spits a lot, and you're more likely to get more bacteria into your bloodstream.”

15. INSTEAD, USE SLOW, STEADY PRESSURE—AND SOME TWEEZERS.

Take a small pair of forceps or tweezers, Sellati instructs, and gently grasp the tick as close to the skin’s surface as possible, “then pull the tick straight up slowly, which pulls the mouth part out of the skin, and then just dab the area with alcohol to disinfect.” A tick’s mouthparts are like tiny barbed hooks, designed to pierce the skin and stay there. “Then they have secretions that cement the mouthparts to the skin, because they have to feed over a long time and they don’t want to be knocked off while they sit and sip.”

Looking to Downsize? You Can Buy a 5-Room DIY Cabin on Amazon for Less Than $33,000

Five rooms of one's own.
Five rooms of one's own.
Allwood/Amazon

If you’ve already mastered DIY houses for birds and dogs, maybe it’s time you built one for yourself.

As Simplemost reports, there are a number of house kits that you can order on Amazon, and the Allwood Avalon Cabin Kit is one of the quaintest—and, at $32,990, most affordable—options. The 540-square-foot structure has enough space for a kitchen, a bathroom, a bedroom, and a sitting room—and there’s an additional 218-square-foot loft with the potential to be the coziest reading nook of all time.

You can opt for three larger rooms if you're willing to skip the kitchen and bathroom.Allwood/Amazon

The construction process might not be a great idea for someone who’s never picked up a hammer, but you don’t need an architectural degree to tackle it. Step-by-step instructions and all materials are included, so it’s a little like a high-level IKEA project. According to the Amazon listing, it takes two adults about a week to complete. Since the Nordic wood walls are reinforced with steel rods, the house can withstand winds up to 120 mph, and you can pay an extra $1000 to upgrade from double-glass windows and doors to triple-glass for added fortification.

Sadly, the cool ceiling lamp is not included.Allwood/Amazon

Though everything you need for the shell of the house comes in the kit, you will need to purchase whatever goes inside it: toilet, shower, sink, stove, insulation, and all other furnishings. You can also customize the blueprint to fit your own plans for the space; maybe, for example, you’re going to use the house as a small event venue, and you’d rather have two or three large, airy rooms and no kitchen or bedroom.

Intrigued? Find out more here.

[h/t Simplemost]

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10 Facts About Real Genius On Its 35th Anniversary

Val Kilmer stars in Martha Coolidge's Real Genius (1985).
Val Kilmer stars in Martha Coolidge's Real Genius (1985).
Sony Pictures Home Entertainment

In an era where nerd is a nickname given by and to people who have pretty much any passing interest in popular culture, it’s hard to imagine the way old-school nerds—people with serious and socially-debilitating obsessions—were once ostracized. Computers, progressive rock, and role-playing games (among a handful of other 1970s- early '80s developments) created a path from which far too many of the lonely, awkward, and conventionally undateable would never return. But in the 1980s, movies transformed these oddballs into underdogs and antiheroes, pitting them against attractive, moneyed, successful adversaries for the fate of handsome boys and pretty girls, cushy jobs, and first-place trophies.

The 1985 film Real Genius ranked first among equals from that decade for its stellar cast, sensitive direction, and genuine nerd bona fides. Perhaps fittingly, it sometimes feels overshadowed, and even forgotten, next to broader, bawdier (and certainly now, more problematic) films from the era like Revenge of the Nerds and Weird Science. But director Martha Coolidge delivered a classic slobs-versus-snobs adventure that manages to view the academically gifted and socially maladjusted with a greater degree of understanding and compassion while still delivering plenty of good-natured humor.

As the movie commemorates its 35th anniversary, we're looking back at the little details and painstaking efforts that make it such an enduring portrait not just of ‘80s comedy, but of nerdom itself.

1. Producer Brian Grazer wanted Valley Girl director Martha Coolidge to direct Real Genius. She wasn’t sure she wanted to.

Following the commercial success of 1984’s Revenge of the Nerds, there was an influx of bawdy scripts that played upon the same idea, and Real Genius was one of them. In 2011, Coolidge told Kickin’ It Old School that the original script for Real Genius "had a lot of penis and scatological jokes," and she wasn't interested in directing a raunchy Nerds knock-off. So producer Brian Grazer enlisted PJ Torokvei (SCTV) and writing partners Babaloo Mandel and Lowell Ganz (Splash, City Slickers) to refine the original screenplay, and then gave Coolidge herself an opportunity to polish it before production started. “Brian's original goal, and mine, was to make a film that focused on nerds as heroes," Coolidge said. "It was ahead of its time."

2. Martha Coolidge’s priority was getting the science in Real Genius right—or at least as right as possible.

In the film, ambitious professor Jerry Hathaway (William Atherton) recruits high-achieving students at the fictional Pacific Technical University (inspired by Caltech) to design and build a laser capable of hitting a human-sized target from space. Coolidge researched the subject thoroughly, working with academic, scientific, and military technicians to ensure that as many of the script and story's elements were correct. Moreover, she ensured that the dialogue would hold up to some scrutiny, even if building a laser of the film’s dimensions wasn’t realistic (and still isn’t today).

3. One element of Real Genius that Martha Coolidge didn’t base on real events turned out to be truer than expected.

From the beginning, the idea that students were actively being exploited by their teacher to develop government technology was always fictional. But Coolidge learned that art and life share more in common than she knew at the time. “I have had so many letters since I made Real Genius from people who said, 'Yes, I was involved in a program and I didn’t realize I was developing weapons,'" she told Uproxx in 2015. “So it was a good guess and turned out to be quite accurate.”

4. Val Kilmer walked into his Real Genius audition already in character—and it nearly cost him the role.

After playing the lead in Top Secret!, Val Kilmer was firmly on Hollywood’s radar. But when he met Grazer at his audition for Real Genius, Kilmer decided to have some fun at the expense of the guy who would decide whether or not he’d get the part. "The character wasn't polite," Kilmer recalled to Entertainment Weekly in 1995. "So when I shook Grazer's hand and he said, 'Hi, I'm the producer,' I said, 'I'm sorry. You look like you're 12 years old. I like to work with men.'"

5. The filmmakers briefly considered using an actual “real genius” to star in Real Genius.

Among the performers considered to play Mitch, the wunderkind student who sets the movie’s story in motion, was a true genius who graduated college at 14 and was starting law school. Late in the casting process, they found their Mitch in Gabriel Jarrett, who becomes the third generation of overachievers (after Kilmer’s Chris and Jon Gries’s Lazlo Hollyfeld) whose talent Hathaway uses to further his own professional goals.

6. Real Genius's female lead inadvertently created a legacy for her character that would continue in animated form.

Michelle Meyrink, Gabriel Jarret, Val Kilmer, and Mark Kamiyama in Real Genius (1985).Sony Pictures Home Entertainment

Michelle Meyrink was a staple of a number of ‘80s comedies, including Revenge of the Nerds. Playing Jordan in Real Genius, she claims to “never sleep” and offers a delightful portrait of high-functioning attention-deficit disorder with a chipper, erratic personality. Disney’s Chip 'n Dale: Rescue Rangers co-creator Tad Stones has confirmed that her character went on to inspire the character of Gadget Hackwrench.

7. A Real Genius subplot, where a computer programmer is gaming a Frito-Lay contest, was based on real events.

In the film, Jon Gries (Napoleon Dynamite) plays Lazlo Hollyfeld, a reclusive genius from before Chris and Mitch’s time who lives in a bunker beneath their dorm creating entries to a contest with no restrictions where he eventually wins more than 30 percent of the prizes. In 1969, students from Caltech tried a similar tactic with Frito-Lay to game the odds. But in 1975, three computer programmers used an IBM to generate 1.2 million entries in a contest for McDonald’s, where they received 20 percent of the prizes (and a lot of complaints from customers) for their effort.

8. One of Real Genius's cast members went on to write another tribute to nerds a decade later.

Dean Devlin, who co-wrote Stargate and Independence Day with Roland Emmerich, plays Milton, another student at Pacific Tech who experiences a memorable meltdown in the rush up to finals.

9. The popcorn gag that ends Real Genius isn’t really possible, but they used real popcorn to simulate it.

At the end of the film, Chris and Mitch build a giant Jiffy Pop pack that the laser unleashes after they redirect its targeting system. The resulting popcorn fills Professor Hathaway’s house as an act of revenge. MythBusters took pains to recreate this gag in a number of ways, but quickly discovered that it wouldn’t work; even at scale, the popcorn just burns in the heat of a laser.

To pull off the scene in the film, Coolidge said that the production had people popping corn for six weeks of filming in order to get enough for the finale. After that, they had to build a house that they could manipulate with hydraulics so that the popcorn would “explode” out of every doorway and window.

10. Real Genius was the first movie to be promoted on the internet.

A week before Real Genius opened, promoters set up a press conference at a computer store in Westwood, California. Coolidge and members of the cast appeared to field questions from press from across the country—connected via CompuServe. Though the experience was evidently marred by technical problems (this was the mid-1980s, after all), the event marked the debut of what became the online roundtable junket.