13 Things to Know About DNA Testing Kits

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The search for our identities—where we came from, what we're made of—is a unifying human experience, and our collective fascination with ourselves as individuals has fueled a booming industry around personal DNA testing. More than 12 million people have had their DNA tested by services like 23andMe and AncestryDNA, and that number is expected to grow substantially in the next few years. But can DNA tests really reveal the nuanced information about ancestry and health that many of us seek? Here are 13 things to know about these personal testing kits.

1. PERSONAL DNA TESTING IS SIMPLE—ALL IT TAKES IS A LITTLE SPIT.

Typically, all you have to do is collect some of your saliva or swab the inside of your cheek, then seal the sample in a container and mail it to the lab in a pre-labeled envelope or box. Six to eight weeks later, you can see the results online.

Most personal DNA tests are relatively affordable: Kits from industry leaders like 23andMe, AncestryDNA, Family Tree DNA, MyHeritage DNA, and Living DNA range from $69 to $199. In some cases, the price depends on which genetic reports a customer opts to receive: For 23andMe, for instance, a test that only aims to analyze your ancestry is cheaper than one that also includes health information. Check out this Wiki chart from the International Society of Genetic Genealogy to compare companies' offerings.

2. THE KITS LOOK FOR GENETIC VARIATIONS CALLED SINGLE NUCLEOTIDE POLYMORPHISMS.

After extracting DNA from your cheek swab or saliva sample, DNA testing companies search your DNA for certain genetic variants. The building blocks of DNA are chemical bases called nucleotides, which come in four varieties—A, T, C, and G (adenine, thymine, cytosine, and guanine, respectively). We have 3 billion pairs of these bases, so 6 billion letters in all, strung together in a sequence. Altogether, this genetic information is called your genome.

DNA testing companies determine which of the four letters is present at many locations in your genome. Much of the sequence is shared among humans, so the companies focus on specific letters that vary from person to person, known as single nucleotide polymorphisms (SNPs). Many SNPs have some biological relevance. For example, having one variant of a specific SNP near the gene OCA2, which codes for a protein believed to be involved in producing the dark pigment melanin, makes it much more likely you’ll have blue or green eyes. Other traits and even some diseases are also associated with certain SNPs, some more strongly than others.

3. KIT ACCURACY CAN VARY BASED ON TESTING METHODS.

According to company spokesperson Scott Hadly, 23andMe can identify SNPs with 99.9 percent accuracy, which is in a plausible range for the methods they use. Since many other major companies use similar techniques, their accuracy may be about equivalent—but not all tests meet the same standards. Recently, one test failed to recognize that a purportedly human DNA sample actually came from a golden retriever named Bailey. It did recommend, though, that based on her genetics, Bailey should take up cycling and basketball. The canine’s results came from the lighthearted Superhero DNA Test, which claims to tell customers about their strength, speed, and intelligence. It only tests for four genetic variants, while the pricier kits can include tens of thousands of variants. (It's also worth noting that no matter how many variants a kit tests for, it can't predict complex traits like intelligence, which are influenced by many different genes and environmental factors.)

You should steer clear of companies that offer dubious predictions about your optimal diet, what sports you'll be good at, and other questionable tips. Experts say using DNA tests to extrapolate this information is at best premature and at worst pseudoscience, especially because the recommendations are often based on just a handful of studies on specific groups of people, commonly white men. "The results that have been acquired in one population are not always generalizable to other populations," Jason Rosenbaum, an assistant professor at the University of Pennsylvania's medical school, tells Mental Floss.

4. DNA CAN REVEAL GENETIC CONNECTIONS—BUT INFORMATION ON SOME POPULATIONS IS LIMITED.

Companies use various methods to determine ancestry, but the tests generally involve comparing the customer's DNA to reference DNA meant to represent populations from different geographical regions. Since most people have at least somewhat mixed heritage, ancestry is often represented in percentages: 26 percent Polish, 14 percent Greek, and so on.

These tests aren’t able to guarantee where your ancestors actually lived—they can’t directly compare your data to DNA from people who lived hundreds of years ago, as Adam Rutherford, a British geneticist, pointed out to Gizmodo. And not all groups of people are equally represented in the reference populations, which can impact how precise your results are. People with European backgrounds are overrepresented in the reference data, while there are fewer references relevant to those whose roots lie in the Middle East or Asia, for example. But as research is done on a more diverse range of people, companies are tweaking their analyses to provide more detailed ancestry information to people from all over the world.

5. SOME HINT AT YOUR DNA'S DISTANT HISTORY—INCLUDING NEANDERTHAL HERITAGE.

All humans alive today can trace their mitochondrial lineage back to one woman nicknamed Mitochondrial Eve, who may have lived in Africa about 150,000–200,000 years ago (although this is a source of perennial debate). She wasn't the first modern human woman or the only woman living at the time; other women from her time also have descendants today. They just don’t have an unbroken line of female descendants like Mitochondrial Eve does.

We inherit our mitochondria—the parts of our cells that make energy—from our mothers. Some companies offer a mitochondrial DNA test that allows you to find your maternal haplogroup, which includes people who all share a maternal ancestor thousands or tens of thousands of years ago.

Men can learn about their paternal line through the Y chromosome, which is passed from father to son; certain SNPs on the Y chromosome can be used to determine a person's paternal haplogroup. (Women can find their paternal haplogroup through their biological father or brother.) There’s a "Y-chromosomal Adam," too, although scientists disagree about whether he lived around the same time as Mitochondrial Eve.

A home DNA test might even tell you that you're a little bit Neanderthal, which is especially common in Caucasian and Asian people. Don't worry about Neanderthals' reputation as dull brutes. We now know they were intelligent, used tools, and had their own complex culture.

6. YOU COULD FIND RELATIVES YOU DIDN'T KNOW YOU HAD.

Many DNA testing services allow customers to see whether other users of the same service are biologically related. This can be a boon for anyone assembling a detailed family tree, as well as any adoptees wondering about their biological families. Several people have discovered siblings they never knew they had through these services. In one case, two women—one adopted through an agency and another adopted by a family who found her in the woods as a baby—realized they were long-lost sisters.

Not everyone is pleased to uncover family secrets, though, and you should proceed with caution before you allow a company to match you with new relatives.

7. DNA TESTS CAN REVEAL HEALTH INFORMATION …

While genetic testing might reveal your inability to detect the unique odor of asparagus pee, most people are seeking deeper information, such as whether they have genetic variants associated with diseases like Alzheimer's or breast cancer.

Genetic risk is all about probability. For example, it may be frightening to learn you have an SNP associated with a tenfold increase in risk for a disease—but if that disease only affects 0.01 percent of people, your risk is still just 0.1 percent. Even if you have a SNP strongly associated with a more common illness and show signs of having it, you should see a doctor to get a proper evaluation.

And having a disease-associated SNP isn't a diagnosis. Rare variants are especially likely to lead to false positives: if a variant is only found in one in a million people, it’s more likely that the positive test result is an error than it would be with a more common variant. Some companies report on genetic variants that doctors and scientists haven't deemed medically useful to test for—which is why combing over every SNP is of dubious use. Shoumita Dasgupta, an associate professor in the biomedical genetics program at Boston University, tells Mental Floss that healthcare providers often don't order tests for these SNPs "because professionals have come to the conclusion that the predictive value of these tests is limited."

8. … INCLUDING YOUR RISK OF CERTAIN KINDS OF CANCER.

In March 2018, the FDA granted 23andMe permission to give customers information about certain mutations in the genes BRCA1 and BRCA2 that dramatically increase the risk for breast and ovarian cancer. Some people with a faulty BRCA gene take precautions to prevent or detect cancer early, including undergoing preventive double mastectomies, as Angelina Jolie famously did in 2013.

An important caveat: This test only screens for three SNPs in the BRCA genes that are connected to a dramatic increase in the risk of developing cancer. A positive result merits a consultation with doctor, but a negative result doesn't necessarily mean you're free from the risk of cancer, hereditary or not.

9. SOME DNA TESTING KITS ARE PRESCRIPTION ONLY.

GeneSight is designed to reveal what psychiatric medications will work best for a particular patient. Fertilome aims to show whether a person has genetic markers associated with increased risk of fertility problems, and is intended to help people make reproductive decisions such as whether to freeze eggs or try another round of in vitro fertilization. However, both Fertilome and GeneSight have faced criticism from experts who say there's not enough evidence that the tests are clinically valuable. They're also expensive: Fertilome costs $950, while GeneSight can cost several hundred dollars (though the price can drop to zero with certain insurance plans).

10. MORE DATA ISN'T ALWAYS BETTER.

With the price of DNA analysis falling rapidly, some companies are offering to analyze the order of all the letters of a customer's DNA—what's called sequencing—rather than just looking at SNPs. Sequencing is important in research and medicine: Dasgupta says she now sees some physicians ordering full sequences of multiple genes or even whole exomes (the protein-coding sequences in the genome) for patients.

Exome sequencing is useful to doctors and scientists because it allows them to look for genetic variants beyond the commonly tested SNPs. But every test has a risk of generating false positives, so excessive testing means an increased risk that a person will receive an incorrect diagnosis. Rosenbaum likens it to MRIs. "It's one reason why we don't just give MRIs to everyone, because you're going to turn up things that lead you to believe there's disease where there isn't disease," he explains.

11. YOUR DNA RESULTS COULD CONTRIBUTE TO RESEARCH.

Some home DNA testing companies ask customers to participate in research, answering questions about everything from their sleep habits to their personalities. The goal is to discover previously unknown associations between genetic variants and specific traits. "The way many genetic studies are designed, the more people who are recruited to the study, the more likely the study will be able to identify genetic factors that impact the trait or condition being studied," Dasgupta says.

Personal DNA testing companies potentially have access to the genetic data of millions of users, giving them a huge opportunity to make these connections. Using customer-provided data, 23andMe has already reported some preliminary discoveries on genetic variants linked to detached earlobes, the risk of Parkinson's disease, and more. Studies based on self-reported information always come with caveats, but they’re common in many fields of research and especially useful when collecting objective data isn't practical or possible. Future research spurred by these observations will reveal whether crowdsourced research like 23andMe's has potential to become part of geneticists' repertoire.

12. YOU COULD POTENTIALLY EARN MONEY FROM YOUR DNA.

One company, Genos, charges $499 to sequence a customer's entire exome, and then offers to connect them with genetic researchers. Participating research partners can offer $50 to $250 to Genos users for completing a study intended to find links between their genetic information and any trait or condition the researchers are studying, including dementia, cancer, and infectious disease. Meanwhile, the newly formed company Nebula proposes to sequence customers' genomes, secure them with blockchain technology, and allow customers to control the data—including selling it to biotech and pharmaceutical companies in exchange for Bitcoin-like cryptocurrency. There’s still potential for privacy issues, however, since there’s no guarantee companies that rent or purchase genetic data will keep it secure.

13. YOUR DNA MIGHT ONE DAY HELP TO CATCH A CRIMINAL.

Recently, police investigators in California arrested a man suspected to be the Golden State Killer, thought to be responsible for dozens of rapes and burglaries and at least 12 murders in California from 1976 to 1986. The suspect left DNA behind at the scene of a 1980 murder; after having the DNA analyzed, the investigators created a fake profile on the genealogy website GEDMatch and uploaded the data, hoping it would turn up some of the killer's relatives. It did—and with the help of genealogy experts, the investigators followed the genetic trail to the Sacramento home of 72-year-old Joseph James DeAngelo, who was a cop during the first several years of the deadly crime spree.

The case has raised ethical and privacy concerns for some experts. Genetic data can be stored indefinitely, and it’s possible to use a person's DNA to make inferences about biological relatives who haven’t even taken DNA tests.

10 Products for a Better Night's Sleep

Amazon/Comfort Spaces
Amazon/Comfort Spaces

Getting a full eight hours of sleep can be tough these days. If you’re having trouble catching enough Zzzs, consider giving these highly rated and recommended products a try.

1. Everlasting Comfort Pure Memory Foam Knee Pillow; $25

Everlasting Comfort Knee Pillow
Everlasting Comfort/Amazon

For side sleepers, keeping the spine, hips, and legs aligned is key to a good night’s rest—and a pain-free morning after. Everlasting Comfort’s memory foam knee pillow is ergonomically designed to fit between the knees or thighs to ensure proper alignment. One simple but game-changing feature is the removable strap, which you can fasten around one leg; this keeps the pillow in place even as you roll at night, meaning you don’t have to wake up to adjust it (or pick it up from your floor). Reviewers call the pillow “life-changing” and “the best knee pillow I’ve found.” Plus, it comes with two pairs of ear plugs.

Buy it: Amazon

2. Letsfit White Noise Machine; $21

Letsfit White Noise Machine
Letsfit/Amazon

White noise machines: They’re not just for babies! This Letsfit model—which is rated 4.7 out of five with nearly 3500 reviews—has 14 potential sleep soundtracks, including three white noise tracks, to better block out everything from sirens to birds that chirp enthusiastically at dawn (although there’s also a birds track, if that’s your thing). It also has a timer function and a night light.

Buy it: Amazon

3. ECLIPSE Blackout Curtains; $16

Eclipse Black Out Curtains
Eclipse/Amazon

According to the National Sleep Foundation, too much light in a room when you’re trying to snooze is a recipe for sleep disaster. These understated polyester curtains from ECLIPSE block 99 percent of light and reduce noise—plus, they’ll help you save on energy costs. "Our neighbor leaves their backyard light on all night with what I can only guess is the same kind of bulb they use on a train headlight. It shines across their yard, through ours, straight at our bedroom window," one Amazon reviewer who purchased the curtains in black wrote. "These drapes block the light completely."

Buy it: Amazon

4. JALL Wake Up Light Sunrise Alarm Clock; $38

JALL Wake Up Light Sunrise Alarm Clock
JALL/Amazon

Being jarred awake by a blaring alarm clock can set the wrong mood for the rest of your day. Wake up in a more pleasant way with this clock, which gradually lights up between 10 percent and 100 percent in the 30 minutes before your alarm. You can choose between seven different colors and several natural sounds as well as a regular alarm beep, but why would you ever use that? “Since getting this clock my sleep has been much better,” one reviewer reported. “I wake up not feeling tired but refreshed.”

Buy it: Amazon

5. Philips SmartSleep Wake-Up Light; $200

Philips SmartSleep Wake-Up Light
Philips/Amazon

If you’re looking for an alarm clock with even more features, Philips’s SmartSleep Wake-Up Light is smartphone-enabled and equipped with an AmbiTrack sensor, which tracks things like bedroom temperature, humidity, and light levels, then gives recommendations for how you can get a better night’s rest.

Buy it: Amazon

6. Slumber Cloud Stratus Sheet Set; $159

Stratus sheets from Slumber Cloud.
Slumber Cloud

Being too hot or too cold can kill a good night’s sleep. The Good Housekeeping Institute rated these sheets—which are made with Outlast fibers engineered by NASA—as 2020’s best temperature-regulating sheets.

Buy it: SlumberCloud

7. Comfort Space Coolmax Sheet Set; $29-$40

Comfort Spaces Coolmax Sheets
Comfort Spaces/Amazon

If $159 sheets are out of your price range, the GHI recommends these sheets from Comfort Spaces, which are made with moisture-wicking Coolmax microfiber. Depending on the size you need, they range in price from $29 to $40.

Buy it: Amazon

8. Coop Home Goods Eden Memory Foam Pillow; $80

Coop Eden Pillow
Coop Home Goods/Amazon

This pillow—which has a 4.5-star rating on Amazon—is filled with memory foam scraps and microfiber, and comes with an extra half-pound of fill so you can add, or subtract, the amount in the pillow for ultimate comfort. As a bonus, the pillows are hypoallergenic, mite-resistant, and washable.

Buy it: Amazon

9. Baloo Weighted Blanket; $149-$169

Baloo Weighted Blanket
Baloo/Amazon

Though the science is still out on weighted blankets, some people swear by them. Wirecutter named this Baloo blanket the best, not in small part because, unlike many weighted blankets, it’s machine-washable and -dryable. It’s currently available in 12-pound ($149) twin size and 20-pound ($169) queen size. It’s rated 4.7 out of five stars on Amazon, with one reviewer reporting that “when it's spread out over you it just feels like a comfy, snuggly hug for your whole body … I've found it super relaxing for falling asleep the last few nights, and it looks nice on the end of the bed, too.” 

Buy it: Amazon 

10. Philips Smartsleep Snoring Relief Band; $200

Philips SmartSleep Snoring Relief Band
Philips/Amazon

Few things can disturb your slumber—and that of the ones you love—like loudly sawing logs. Philips’s Smartsleep Snoring Relief Band is designed for people who snore when they’re sleeping on their backs, and according to the company, 86 percent of people who used the band reported reduced snoring after a month. The device wraps around the torso and is equipped with a sensor that delivers vibrations if it detects you moving to sleep on your back; those vibrations stop when you roll onto your side. The next day, you can see how many hours you spent in bed, how many of those hours you spent on your back, and your response rate to the vibrations. The sensor has an algorithm that notes your response rate and tweaks the intensity of vibrations based on that. “This device works exactly as advertised,” one Amazon reviewer wrote. “I’d say it’s perfect.”

Buy it: Amazon

This article contains affiliate links to products selected by our editors. Mental Floss may receive a commission for purchases made through these links.

Common Misconceptions About Dreams

If your nightmares look like Henry Fuseli's The Nightmare (1781), we're so sorry.
If your nightmares look like Henry Fuseli's The Nightmare (1781), we're so sorry.
Henry Fuseli, Detroit Institute of Arts, Wikimedia Commons // Public Domain

Contrary to what Ebenezer Scrooge initially thought in Charles Dickens's A Christmas Carol, nightmares aren’t merely a side effect of eating cheese before bed. In fact, studies have shown that pre-sleep snacks—dairy or otherwise—probably don’t influence your dreams at all. But even if you can’t blame your latest wacky snooze vision on last night’s midnight helping of chicken nuggets, you can try to trace it back to some stressor from your daily life.

Since dream interpretation isn’t an exact science—and sleep in general is one of science’s murkier territories—quite a few myths have arisen about what, why, and how we dream. In this episode of Misconceptions, Mental Floss's own Justin Dodd walks us through some of the more common fallacies about dreams. (And if you’re convinced you never dream, well, he has some news for you on that front, too.)

For more videos like this one, subscribe to the Mental Floss YouTube channel here.