How Do Hormones Affect Emotions?Ray Schilling:
1. Serotonin production in the brain is important to prevent depression. Datis Kharrazian’s book Why isn’t my brain working? offers several scenarios that can cause depression and he has examples of cases that were cured of depression. He points out that deficiencies in two major brain transmitters can cause depression: serotonin and dopamine.
Serotonin is produced in the midbrain from the amino acid tryptophan in two biochemical steps. These biochemical conversions require iron, vitamin B6, vitamin B12, niacin, folic acid, and magnesium as co-factors. But you also need the “large neutral amino acid transporter” (LNAA) to transport tryptophan through the blood-brain barrier into the brain.
Dopamine is a neurotransmitter that is produced in the frontal lobes of the brain. It is also necessary for learning. Dopamine is synthesized by the brain from tyrosine, which has to be manufactured in the liver from the amino acid phenylalanine. You need to have a healthy liver to produce tyrosine, which needs to be transported through the blood-brain barrier into the brain; similar to tryptophan this requires the “large neutral amino acid transporter” (LNAA). People with hepatitis, fatty liver, insulin resistance or diabetes may have problems with the LNAA transporter, which can cause dopamine deficiency. But as mentioned earlier they may also have low serotonin because tryptophan was not transported into the brain. This will happen with sugar overconsumption, as insulin resistance develops and affects the LNAA transporter resulting in both low serotonin and dopamine.
2. When testosterone is missing in an aging man, this causes low energy, depression, a lack of drive, and erectile dysfunction. You replace testosterone in appropriate doses and all of that normalizes. The reason for that is that many key organs including the brain have testosterone receptors. They need to be activated regularly by testosterone for normal organ function. Women need a small amount of testosterone as well to feel normal.
3. Estrogen hormones are the female hormones. If they are normal and balanced by progesterone (from the corpus luteum in the second half of the menstrual cycle) a woman feels well. There is a condition called estrogen dominance where too much estrogen is circulating in relation to progesterone, and these women have the following symptoms:
- Irregular or otherwise abnormal menstrual periods
- Decreased sex drive
- Bloating (water retention)
- Breast swelling and tenderness.
- Fibrocystic breasts.
- Headaches (especially premenstrually)
- Mood swings (most often irritability and depression)
If the ratio can be normalized between progesterone and estrogen by the use of bioidentical progesterone, these symptoms disappear and the woman feels normal. Again it is the stimulation of the hormone receptors in just the right manner, which stabilizes the mood and leads to normal body function.
4. If thyroid hormones are missing, the person gets depressed and has a lack of energy. Thyroid hormones are stimulating cell function in all the body cells including the brain. Again this is transmitted by hormone receptors in the cells. It is easy for a physician to measure thyroid hormone levels (TSH and thyroid hormone levels) and to rectify the situation by ordering the right amount of thyroid hormones. When thyroid hormone receptor stimulation is normalized, all of the symptoms disappear and the person will feel normal again.
Hormones do not act in isolation, but in concert. Thyroid hormones give the body cells energy. Other hormones add to this and at the end we feel normal.
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