How Your Brain Fights Sleep Even When You're Exhausted

iStock
iStock

Maybe you’ve got an exam in the morning, or there’s just one more episode left in this season. Whatever the reason, tonight you ignore your body’s demands and stay up instead. It’s an impressive feat, if you think about it—sleep is essential—and now scientists may be closer to understanding how we do it. They published a report on their findings in the journal Neuron.

There’s a little section of your brainstem called the dorsal raphe nucleus (DRN). This region is responsible for making serotonin and other brain chemicals.

Lead researcher Viviana Gradinaru of Caltech says previous studies have also suggested that the dorsal raphe nucleus plays a role in helping keep us awake.

"People who have damage in this part of their brain have been shown to experience excessive daytime sleepiness,” she said in a statement, “but there was not a good understanding of the exact role of these neurons in the sleep/wake cycle and whether they react to internal or external stimuli to influence arousal."

Within the dorsal raphe nucleus lies a little-understood group of dopamine cells called the dorsal raphe nucleus neurons (DRNDA).

Dorsal raphe nucleus neurons responding to light (green) and chemical (red) signals. Viviana Gradinaru

Gradinaru and her colleagues wanted to know if voluntary wakefulness had anything to do with dopamine activity within these cells. They started by studying mouse brains, which are similar to our own in many ways.

The researchers monitored the rodents’ DRNDA action while the mice were fed, met new potential mates, or experienced sudden unpleasant sensations—all experiences for which the mice would want or need to stay awake. Throughout the experiences, the mice’s DRNDA cells kept very busy, sending bursts of dopamine to other parts of the brain.

Next, the scientists tracked DRNDA cell activity as the mice slept and woke. They found that the cells seemed to sleep when the mice did, and revved up when the mice got up.

So far, the researchers knew that the sleeping mouse/sleeping neurons and waking mouse/waking neurons pairs existed, but they couldn’t tell if the neurons caused the waking or vice versa.

To find out, they engineered DRNDA cells that could be switched on and off by light. They then bred mice with these light-sensitive cells and let them sleep. As the mice snoozed, the researchers switched on the lights and their DRNDA cells using a technique called optogenetics. Sure enough, the mice woke up.

Shutting off DRNDA cells had the opposite effect: Mice with no DRNDA activity couldn’t keep their eyes open, even when faced with danger, loud noises, or the possibility of mating.

The authors note that their experiments included only mice, and that it’s too soon to draw conclusions about what this might mean for people.

“Further work is necessary to establish causation in humans,” Gradinaru said, “and to test the potential of the DRNDA as a therapeutic target for insomnia or oversleeping, and for sleep disturbances that accompany other psychiatric disorders such as depression, bipolar disorder, and schizophrenia."

Amazon's Best Black Friday Deals: Tech, Video Games, Kitchen Appliances, Clothing, and More

Amazon
Amazon

This article contains affiliate links to products selected by our editors. Mental Floss may receive a commission for purchases made through these links.

Black Friday is finally here, and Amazon is offering great deals on kitchen appliances, tech, video games, and plenty more. We will keep updating this page as sales come in, but for now, here are the best Amazon Black Friday sales to check out.

Kitchen

Instant Pot/Amazon

- Instant Pot Duo Plus 9-in-115 Quart Electric Pressure Cooker; $90 (save $40)

- Keurig K-Cafe Special Edition; $190 (save $30)

- Ninja OS301 Foodi 10-in-1 Pressure Cooker and Air Fryer; $125 (save $75)

- Nespresso Vertuo Next Coffee and Espresso Machine by Breville; $120 (save $60)

- KitchenAid KSMSFTA Sifter with Scale Attachment; $95 (save $75)

- Keurig K-Mini Coffee Maker; $60 (save $20)

- Cuisinart Bread Maker; $80 (save $97)

- Anova Culinary Sous Vide Precision Cooker; $139 (save $60)

- Aicook Juicer Machine; $35 (save $15)

- JoyJolt Double Wall Insulated Espresso Mugs - Set of Two; $14 (save $10)

- Longzon Silicone Stretch Lids - Set of 14; $16 (save $11)

- HadinEEon Milk Frother; $37 (save $33)

Home Appliances

Roomba/Amazon

- iRobot Roomba 675 Robot Vacuum with Wi-Fi Connectivity; $179 (save $101)

- ASAKUKI 500ml Premium Essential Oil Diffuser; $22 (save $4)

- Facebook Portal Smart Video Calling 10 inch Touch Screen Display with Alexa; $129 (save $50)

- Bissell air320 Smart Air Purifier with HEPA and Carbon Filters; $280 (save $50)

- Oscillating Quiet Cooling Fan Tower; $59 (save $31)

- TaoTronics PTC 1500W Fast Quiet Heating Ceramic Tower; $55 (save $10)

- Vitamix 068051 FoodCycler 2 Liter Capacity; $300 (save $100)

- Ring Video Doorbell; $70 (save $30)

Video games

Sony

- Marvel's Spider-Man: Game of The Year Edition for PlayStation 4; $20 (save $20)

- The Legend of Zelda: Link's Awakening; $40 (save $20)

- Hyrule Warriors: Age of Calamity; $50 (save $10)

- Marvel's Avengers; $25 (save $33)

- The Last of Us Part II for PlayStation 4; $30 (save $30)

- LEGO Harry Potter: Collection; $15 (save $15)

- Ghost of Tsushima; $40 (save $20)

- BioShock: The Collection; $20 (save $30)

- The Sims 4; $24 (save $20)

- God of Warfor PlayStation 4; $10 (save $10)

- Days Gonefor PlayStation 4; $20 (save $6)

- Luigi's Mansion 3 for Nintendo Switch; $40 (save $20)

Computers and tablets

Microsoft/Amazon

- New Apple MacBook Pro 16 inches with 512 GB; $2149 (save $250)

- Microsoft Surface Laptop 3 with 13.5 inch Touch-Screen; $1200 (save $400)

- Lenovo ThinkPad T490 Laptop; $889 (save $111)

- Amazon Fire HD 10 Tablet (64GB); $120 (save $70)

- Amazon Fire HD 10 Kids Edition Tablet (32 GB); $130 (save $70)

- Apple iPad Mini (64 GB); $335 (save $64)

- Vankyo MatrixPad S2 Tablet; $120 (save $10)

Tech, gadgets, and TVs

Apple/Amazon

- Apple Watch Series 3 with GPS; $120 (save $79)

- Seneo Wireless Charger, 3 in 1 Wireless Charging Station; $16 (save $10)

- SAMSUNG 75-inch Class Crystal 4K Smart TV; $998 (save $200)

- Nixplay 2K Smart Digital Picture Frame 9.7 Inch Silver; $238 (save $92)

- All-New Amazon Echo Dot with Clock and Alexa (4th Gen); $39 (save $21)

- MACTREM LED Ring Light 6" with Tripod Stand; $16 (save $3)

- Amazon Fire TV Stick with Alexa Voice Remote; $28 (save $12)

- DR. J Professional HI-04 Mini Projector; $93 (save $37)

Headphones and speakers

Beats/Amazon

- Beats Solo3 Wireless On-Ear Headphones; $120 (Save $80)

- Apple AirPods Pro; $169 (save $50)

- Anker Soundcore Upgraded Bluetooth Speaker; $22 (save $8)

- Powerbeats Pro Wireless Earphones; $175 (save $75)

- JBL Boombox; $280 (save $120)

Movies and TV

HBO/Amazon

- Game of Thrones: The Complete Series; $115 (save $89)

- Jurassic World 5-Movie Set; $23 (save $37)

- Deadwood: The Complete Series; $42 (save $28)

- Back to the Future Trilogy; $15 (save $21)

Toys and Games

Amazon

- Awkward Family Photos Greatest Hits; $15 (save $10)

- Exploding Kittens Card Game; $10 (save $10)

- Cards Against Humanity: Hidden Gems Bundle; $14 (save $5)

- LOL Surprise OMG Remix Pop B.B. Fashion Doll; $29 (save $6)

- LEGO Ideas Ship in a Bottle 92177 Expert Building Kit; $56 (save $14)

Furniture

Casper/Amazon

- Casper Sleep Element Queen Mattress; $476 (save $119)

- ZINUS Alexis Deluxe Wood Platform Bed Frame; $135 (save $24)

- ROMOON Dresser Organizer with 5 Drawers; $59 (save $11) 

- AmazonBasics Room Darkening Blackout Window Curtains; $26 (save $5)

- Writing Desk by Caffoz; $119 (save $21)

- SPACE Seating Office Support Managers Chair; $112 (save $116)

- Rivet Globe Stick Table Lamp; $53 (save $17)

- Christopher Knight Home Merel Mid-Century Modern Club Chair; $188 (save $10)

- Walker Edison Furniture Industrial Rectangular Coffee Table; $121 (save $48)

Beauty

Haus/Amazon

- MySmile Teeth Whitening Kit with LED Light; $21 (save $12) 

- Cliganic USDA Organic Lip Balms Set of Six; $6 (save $4)

- HAUS LABORATORIES By Lady Gaga: LE RIOT LIP GLOSS; $7 (save $11)

- Native Deodorant for Men and Women Set of Three; $25 (save $11) 

- BAIMEI Rose Quartz Jade Roller & Gua Sha; $14 (save $3)

- Honest Beauty Clearing Night Serum with Pure Retinol and Salicylic Acid; $20 (save $8)

- WOW Apple Cider Vinegar Shampoo and Hair Conditioner Set; $30 (save $5) 

- La Roche-Posay Effaclar Purifying Foaming Gel Cleanser; $15 (save $5)

- wet n wild Bretman Rock Shadow Palette; $9 (save $6)

- EltaMD UV Daily Tinted Face Sunscreen Moisturizer with Hyaluronic Acid; $25 (save $6)

Clothes

Ganni/Amazon

- Ganni Women's Crispy Jacquard Dress; $200 (save $86) 

- The Drop Women's Maya Silky Slip Skirt; $36 (save $9)

- Steve Madden Women's Editor Boot; $80 (save $30)

- adidas Women's Roguera Cross Trainer; $40 (save $25)

- Line & Dot Women's Elizabeth Sweater; $74 (save $18)

- Levi's Men's Sherpa Trucker Jacket; $57 (save $41)

- Adidas Men's Essentials 3-Stripes Tapered Training Joggers Sweatpants; $28 (save $12)

- Timex Men's Weekender XL 43mm Watch; $32 (save $20)

- Ray-Ban Unisex-Adult Hexagonal Flat Lenses Sunglasses; $108 (save $46) 

- Reebok Men's Flashfilm Train Cross Trainer; $64 (save $16)

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How Much Is the Earth Worth?

The New York Public Library, Unsplash
The New York Public Library, Unsplash

Our home planet may be the most precious place we know, but it isn't priceless. The Earth's resources and the value it offers to humans add up to some unknown, tangible cost. The species may never have to worry about buying or selling the world, but thinking of it in terms of concrete numbers can help us better understand its value. Now, as Treehugger reports, one scientist has developed a special formula that allows us to do just that.

According to the calculations of Greg Laughlin, an assistant astronomy and astrophysics professor from the University of California, Santa Cruz, the Earth is worth roughly $5 quadrillion (or $5,000,000,000,000,000). He came up with that price after gauging the planet's mass, temperature, age, and other factors that directly correlate to its ability to sustain life.

To emphasize just how valuable the Earth is, Laughlin also estimated the worth of other planets in our solar system. Our nearest neighbor Mars costs about the same as a used car at $16,000. That's a fortune compared to Venus, which he appraised at the meager value of one cent.

Laughlin doesn't expect these numbers to have applications in the real world. Rather, he hopes they will inspire people to better appreciate the only home they know. He's not the first person to put a massive, hypothetical price tag on something just for fun. The cost of the Death Star from Star Wars has been calculated at $852 quadrillion—many times Laughlin's estimate for Earth.

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