Play a Game to Help Scientists Defeat a Cancer-Causing Toxin

Habibou Kouyate, Stringer, Getty Images
Habibou Kouyate, Stringer, Getty Images

If you're used to fighting virtual zombies or flying spaceships on your computer, a new series of games available on Foldit may sound a little unconventional. The object of the Aflatoxin Challenge is to rearrange protein structures and create new enzymes. But its impact on the real world could make it the most important game you've ever played: The scientists behind it hope it will lead to a new way to fight one of the most ruthless causes of liver cancer.

As Fast Company reports, the citizen science project is a collaboration between Mars, Inc. and U.C. Davis, the University of Washington, the Partnership for Aflatoxin Control in Africa, and Thermo Fisher Scientific. The team's online puzzles, which debuted on Foldit earlier this month, invite the public to create a new enzyme capable of finding and destroying carcinogens known as aflatoxins.

Aflatoxins form when certain fungi grow on crops like corn, nuts, and grains. Developing countries often don't have the resources to detect it in food, leaving around 4.5 billion people vulnerable to it. When people do eat food with high aflatoxin levels unknowingly, they can contract liver cancer. Roughly a quarter of all liver cancer cases around the world can be traced back to aflatoxin exposure.

The toxin's connection to agriculture is why the food giant Mars is so interested in fighting it. By working on a way to stop aflatoxins on a molecular level, the company could prevent its spread more efficiently than they would with less direct methods like planting drought-resistant crops or removing mold by hand.

The easiest way for scientists to eradicate an aflatoxin before it causes real harm is by making an enzyme that does the work for them. With the Aflatoxin Challenge, the hope is that by manipulating protein structures, online players will come up with an enzyme that attacks aflatoxins at a susceptible portion of their molecular structure called a lactone ring. Destroying the lactone ring makes aflatoxin much less toxic and essentially safe to eat.

The University of Washington launched Foldit in 2008. Since then, the online puzzle platform has been used to study a wide range of diseases including AIDS and Chikungunya. Everyone is welcome to contribute to the Foldit's new aflatoxin project for the next several weeks or so, after which scientists will synthesize genes based on the most impressive results to be used in future studies.

[h/t Fast Company]

Mental Floss's Three-Day Sale Includes Deals on Apple AirPods, Sony Wireless Headphones, and More

Apple
Apple

During this weekend's three-day sale on the Mental Floss Shop, you'll find deep discounts on products like AirPods, Martha Stewart’s bestselling pressure cooker, and more. Check out the best deals below.

1. Apple AirPods Pro; $219

Apple

You may not know it by looking at them, but these tiny earbuds by Apple offer HDR sound, 30 hours of noise cancellation, and powerful bass, all through Bluetooth connectivity. These trendy, sleek AirPods will even read your messages and allow you to share your audio with another set of AirPods nearby.

Buy it: The Mental Floss Shop

2. Sony Zx220bt Wireless On-Ear Bluetooth Headphones (Open Box - Like New); $35

Sony

For the listener who likes a traditional over-the-ear headphone, this set by Sony will give you all the same hands-free calling, extended battery power, and Bluetooth connectivity as their tiny earbud counterparts. They have a swivel folding design to make stashing them easy, a built-in microphone for voice commands and calls, and quality 1.18-inch dome drivers for dynamic sound quality.

Buy it: The Mental Floss Shop

3. Sony Xb650bt Wireless On-Ear Bluetooth Headphones; $46

Sony

This Sony headphone model stands out for its extra bass and the 30 hours of battery life you get with each charge. And in between your favorite tracks, you can take hands-free calls and go seamlessly back into the music.

Buy it: The Mental Floss Shop

4. Martha Stewart 8-quart Stainless-Steel Pressure Cooker; $65

Martha Stewart

If you’re thinking of taking the plunge and buying a new pressure cooker, this 8-quart model from Martha Stewart comes with 14 presets, a wire rack, a spoon, and a rice measuring cup to make delicious dinners using just one appliance.

Buy it: The Mental Floss Shop

5. Jashen V18 350w Cordless Vacuum Cleaner; $180

Jashen

If you're obsessive about cleanliness, it's time to lose the vacuum cord and opt for this untethered model from JASHEN. Touting a 4.3-star rating from Amazon, the JASHEN cordless vacuum features a brushless motor with strong suction, noise optimization, and a convenient wall mount for charging and storage.

Buy it: The Mental Floss Shop

6. Evachill Ev-500 Personal Air Conditioner; $65

Evachill

This EvaChill personal air conditioner is an eco-friendly way to cool yourself down in any room of the house. You can set it up at your work desk at home, and in just a few minutes, this portable cooling unit can drop the temperature by 59º. All you need to do is fill the water tank and plug in the USB cord.

Buy it: The Mental Floss Shop

7. Gourmia Gcm7800 Brewdini 5-Cup Cold Brew Coffee Maker; $120

Gourmia

The perfect cup of cold brew can take up to 12 hours to prepare, but this Gourmia Cold Brew Coffee Maker can do the job in just a couple of minutes. It has a strong suction that speeds up brew time while preserving flavor in up to five cups of delicious cold brew at a time.

Buy it: The Mental Floss Shop

8. Townew: The World's First Self-Sealing Trash Can; $90

Townew

Never deal with handling gross garbage again when you have this smart bin helping you in the kitchen. With one touch, the Townew will seal the full bag for easy removal. Once you grab the neatly sealed bag, the Townew will load in a new clean one on its own.

Buy it: The Mental Floss Shop

9. Light Smart Solar Powered Parking Sensor (Two-Pack); $155

FenSens

Parking sensors are amazing, but a lot of cars require a high trim to access them. You can easily upgrade your car—and parking skills—with this solar-powered parking sensor. It will give you audio and visual alerts through your phone for the perfect parking job every time.

Buy it: The Mental Floss Shop

10. Liz: The Smart Self-Cleaning Bottle With UV Sterilization; $46

Noerden

Reusable water bottles are convenient and eco-friendly, but they’re super inconvenient to get inside to clean. This smart water bottle will clean itself with UV sterilization to eliminate 99.9 percent of viruses and bacteria. That’s what makes it clean, but the single-tap lid for temperature, hydration reminders, and an anti-leak functionality are what make it smart.

Buy it: The Mental Floss Shop

Prices subject to change.

This article contains affiliate links to products selected by our editors. Mental Floss may receive a commission for purchases made through these links. If you haven't received your voucher or have a question about your order, contact the Mental Floss shop here.

100 Fascinating Facts About Earth

The best Spaceball.
The best Spaceball.
NASA

Did you know that there’s a place in the South Pacific Ocean called Point Nemo that’s farther from land than any other point on Earth? So far, in fact, that the closest humans are usually astronauts aboard the International Space Station. (And by the way: The map you’re about to look for Point Nemo on might not be entirely accurate; a certain amount of distortion occurs when trying to depict a 3D planet on a 2D surface.)

In this all-new episode of The List Show, Mental Floss editor-in-chief Erin McCarthy is journeying to the center of the Earth, and visiting its oceans, its atmosphere, and even space, in search of 100 facts about our endlessly fascinating planet.

The subjects that fall under the umbrella of “facts about Earth” are nearly as expansive as Earth itself. Geology, biology, astronomy, and cartography, are all fair game—and those are just a few of the many -ologies, -onomies, and -ographies you’ll learn about below. 

Press play to find out more Earth-shattering facts, and subscribe to the Mental Floss YouTube channel for more fact-filled videos here.