New Patient Test Could Suggest Whether Therapy or Meds Will Work Better for Anxiety

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Like many psychological disorders, there's no one-size-fits-all treatment for patients with anxiety. Some might benefit from taking antidepressants, which boost mood-affecting brain chemicals called neurotransmitters. Others might respond better to therapy, and particularly a form called cognitive behavioral therapy, or CBT.

Figuring out which form of treatment works best often requires months of trial and error. But experts may have developed a quick clinical test to expedite this process, suggests a new study published in the journal Neuropsychopharmacology.

Researchers at the University of Illinois at Chicago have noted that patients with higher levels of anxiety exhibit more electrical activity in their brains when they make a mistake. They call this phenomenon error-related negativity, or ERN, and measure it using electroencephalography (EEG), a test that records the brain's electric signals.

“People with anxiety disorders tend to show an exaggerated neural response to their own mistakes,” the paper’s lead author, UIC psychiatrist Stephanie Gorka, said in a news release. “This is a biological internal alarm that tells you that you've made a mistake and that you should modify your behavior to prevent making the same mistake again. It is useful in helping people adapt, but for those with anxiety, this alarm is much, much louder.”

Gorka and her colleagues wanted to know whether individual differences in ERN could predict treatment outcomes, so they recruited 60 adult volunteers with various types of anxiety disorders. Also involved was a control group of 26 participants with no history of psychological disorders.

Psychiatrists gauged subjects’ baseline ERN levels by having them wear an EEG cap while performing tricky computer tasks. Ultimately, they all made mistakes thanks to the game's challenging nature. Then, randomized subjects with anxiety disorders were instructed to take an SSRI antidepressant every day for three months, or receive weekly cognitive behavioral therapy for the same duration. (Cognitive behavioral therapy is a type of evidence-based talk therapy that forces patients to challenge maladaptive thoughts and develop coping mechanisms to modify their emotions and behavior.)

After three months, the study's patients took the same computer test while wearing EEG caps. Researchers found that those who'd exhibited higher ERN levels at the study's beginning had reduced anxiety levels if they'd been treated with CBT compared to those treated with medication. This might be because the structured form of therapy is all about changing behavior: Those with enhanced ERN might be more receptive to CBT than other patients, as they're already preoccupied with the way they act.

EEG equipment sounds high-tech, but it's relatively cheap and easy to access. Thanks to its availability, UIC psychiatrists think their anxiety test could easily be used in doctors’ offices to measure ERN before determining a course of treatment.

Here’s What You Need to Know About the New Coronavirus

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jarun011/iStock via Getty Images

This morning, the Centers for Disease Control and Prevention (CDC) confirmed the second case of the recently discovered coronavirus in the U.S. Find out what it is, where it is, how to avoid it, and all the other need-to-know information about the illness below.

What is the new coronavirus?

Coronaviruses are a group of viruses named for the crown-shaped spikes that cover their surfaces (corona is the Latin word for crown). According to the CDC, human coronaviruses can cause upper-respiratory tract illnesses, including the common cold, and can sometimes lead to more severe lower-respiratory tract issues like pneumonia or bronchitis.

Because this latest coronavirus, 2019-nCoV, is so new, health officials are currently trying to figure out how it works and how to treat it. It’s not the first time a potent new coronavirus has caused an international outbreak: SARS-CoV originated in Asia and spread to more than two dozen countries in 2003, and MERS-CoV first infected people in Saudi Arabia before spreading across the globe in 2012.

Where is the coronavirus outbreak happening?

The majority of cases are in China, which counts more than 800 confirmed diagnoses. Most are in Wuhan, a city in China’s Hubei province where 2019-nCoV was first detected last month. Additional cases have been reported in South Korea, Japan, Singapore, Hong Kong, Macao, Taiwan, Thailand, and Vietnam.

The CDC has confirmed two U.S. cases—a man in his thirties outside Seattle, and a 60-year-old woman in Chicago—both of whom had recently returned from trips to Wuhan. A CDC official said another 63 potential cases are being investigated in 22 states, and airports in New York, Chicago, Los Angeles, Atlanta, and San Francisco are conducting health screenings on passengers arriving from China.

Chinese officials have shut down transportation to and from Wuhan. Tourist spots like Beijing’s Forbidden City, Shanghai Disneyland, and a portion of the Great Wall are also closed temporarily.

What are the symptoms of the new coronavirus?

Symptoms are similar to those caused by a cold or the flu, including fever, dry cough, and breathing difficulty. The New York Times reported that as of Friday morning, 25 people in China have died from the virus, and most of them were older men with preexisting health conditions like cirrhosis, diabetes, and Parkinson’s disease.

How does the new coronavirus spread?

Because most of the early cases of 2019-nCoV were traced back to a seafood and meat market in Wuhan, health officials think the virus originally spread from infected animals to humans, but it’s now being transmitted from person to person.

Though scientists are still studying exactly how that happens, the leading theory is that it travels in tiny droplets of fluid from the respiratory tract when a person coughs or sneezes.

How do you avoid the new coronavirus?

The CDC is warning everyone to avoid any nonessential trips to Wuhan, and to avoid animals or sick people if you’re traveling elsewhere in China. If you’ve been to China in the last two weeks and experience any of the symptoms listed above, you should seek medical attention immediately—and you should call the doctor’s office or emergency room beforehand to let them know you’re coming.

Otherwise, simply stick to the precautions you’d normally take when trying to stay healthy: Wash your hands often with soap and water, cover your nose and mouth when coughing or sneezing, stay away from sick people, and thoroughly cook any meat or eggs before eating them.

Should you be worried about the new coronavirus?

The global health community is taking 2019-nCoV seriously in order to curb the outbreak as quickly as possible, but you shouldn’t panic. The CDC maintains that it’s a low-risk situation in the U.S., and public health officials are echoing that message.

“We don’t want the American public to be worried about this, because their risk is low,” Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told USA Today.

[h/t USA Today]

Has An Element Ever Been Removed From the Periodic Table?

lucadp/iStock via Getty Images
lucadp/iStock via Getty Images

Barry Gehm:

Yes, didymium, or Di. It was discovered by Carl Mosander in 1841, and he named it didymium from the Greek word didymos, meaning twin, because it was almost identical to lanthanum in its properties. In 1879, a French chemist showed that Mosander’s didymium contained samarium as well as an unknown element. In 1885, Carl von Weisbach showed that the unknown element was actually two elements, which he isolated and named praseodidymium and neodidymium (although the di syllable was soon dropped). Ironically, the twin turned out to be twins.

The term didymium filter is still used to refer to welding glasses colored with a mixture of neodymium and praseodymium oxides.

One might cite as other examples various claims to have created/discovered synthetic elements. Probably the best example of this would be masurium (element 43), which a team of German chemists claimed to have discovered in columbium (now known as niobium) ore in 1925. The claim was controversial and other workers could not replicate it, but some literature from the period does list it among the elements.

In 1936, Emilio Segrè and Carlo Perrier isolated element 43 from molybdenum foil that had been used in a cyclotron; they named it technetium. Even the longest-lived isotopes of technetium have a short half-life by geological standards (millions of years) and it has only ever been found naturally in minute traces as a product of spontaneous uranium fission. For this reason, the original claim of discovery (as masurium) is almost universally regarded as erroneous.

As far as I know, in none of these cases with synthetic elements has anyone actually produced a quantity of the element that one could see and weigh that later turned out not to be an element, in contrast to the case with didymium. (In the case of masurium, for instance, the only evidence of its existence was a faint x-ray signal at a specific wavelength.)

This post originally appeared on Quora. Click here to view.

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