More Studies See Links Between Alzheimer's and Herpes

iStock
iStock

Although it was discovered in 1906, Alzheimer’s disease didn’t receive significant research attention until the 1970s. In 1984, scientists identified the plaque-like buildup of amyloid beta proteins in brain tissue that causes nerve damage and can lead to symptoms like memory loss, personality changes, and physical debility.

Now, researchers are learning why amyloid beta tends to collect in brain tissue like barnacles on a ship. It might not be rallying expressly to cause damage, but to protect the brain from another invader: the herpes simplex virus.

As The Atlantic recently noted, a number of studies have strengthened the notion that amyloid beta activity is working in response to herpes, the virus that travels along nerve pathways and typically causes cold sores around the mouth (HSV-1) or genitals (HSV-2). In a study involving mice, those engineered to produce more amyloid beta were more resistant to the herpes virus than those who were not.

But when too much amyloid beta is produced to combat the virus, the proteins can affect the brain’s neurons. And while herpes tends to target specific pathways in the body that result in external sores, it’s possible that the virus might act differently in an older population that is susceptible to more widespread infection. Roughly half of adults under age 50 in the U.S. are infected with HSV-1 and 12 percent with HSV-2, which suggests that a large swath of the population could be vulnerable to Alzheimer's disease. Two other strains of the virus, HHV-6A and HHV-7, have also been found to be more common in the brains of deceased Alzheimer’s patients than in the general population.

More research will be needed to further understand the possible relationship between the two. If more findings support the theory, then it’s possible that antiviral drugs or vaccines targeting herpes might also reduce the chances of amyloid beta buildup.

[h/t Atlantic]

Looking to Downsize? You Can Buy a 5-Room DIY Cabin on Amazon for Less Than $33,000

Five rooms of one's own.
Five rooms of one's own.
Allwood/Amazon

If you’ve already mastered DIY houses for birds and dogs, maybe it’s time you built one for yourself.

As Simplemost reports, there are a number of house kits that you can order on Amazon, and the Allwood Avalon Cabin Kit is one of the quaintest—and, at $32,990, most affordable—options. The 540-square-foot structure has enough space for a kitchen, a bathroom, a bedroom, and a sitting room—and there’s an additional 218-square-foot loft with the potential to be the coziest reading nook of all time.

You can opt for three larger rooms if you're willing to skip the kitchen and bathroom.Allwood/Amazon

The construction process might not be a great idea for someone who’s never picked up a hammer, but you don’t need an architectural degree to tackle it. Step-by-step instructions and all materials are included, so it’s a little like a high-level IKEA project. According to the Amazon listing, it takes two adults about a week to complete. Since the Nordic wood walls are reinforced with steel rods, the house can withstand winds up to 120 mph, and you can pay an extra $1000 to upgrade from double-glass windows and doors to triple-glass for added fortification.

Sadly, the cool ceiling lamp is not included.Allwood/Amazon

Though everything you need for the shell of the house comes in the kit, you will need to purchase whatever goes inside it: toilet, shower, sink, stove, insulation, and all other furnishings. You can also customize the blueprint to fit your own plans for the space; maybe, for example, you’re going to use the house as a small event venue, and you’d rather have two or three large, airy rooms and no kitchen or bedroom.

Intrigued? Find out more here.

[h/t Simplemost]

This article contains affiliate links to products selected by our editors. Mental Floss may receive a commission for purchases made through these links.

The Psychological Tricks Disney Parks Use to Make Long Wait Times More Bearable

© Jorge Royan, Wikimedia Commons // CC BY-SA 3.0
© Jorge Royan, Wikimedia Commons // CC BY-SA 3.0

No one goes to Disneyland or Disney World to spend the day waiting in line, but when a queue is well-designed, waiting can be part of the experience. Disney knows this better than anyone, and the parks' Imagineers have developed several tricks over the years to make long wait times as painless as possible.

According to Popular Science, hacking the layout of the line itself is a simple way to influence the rider's perspective. When a queue consists of 200 people zig-zagging around ropes in a large, open room, it's easy for waiting guests to feel overwhelmed. This design allows riders to see exactly how many people are in line in front of them—which isn't necessarily a good thing when the line is long.

Imagineers prevent this by keeping riders in the dark when they enter the queue. In Space Mountain, for example, walls are built around the twisting path, so riders have no idea how much farther they have to go until they're deeper into the building. This stops people from giving up when they first get in line.

Another example of deception ride designers use is the "Machiavellian twist." If you've ever been pleasantly surprised by a line that moved faster than you expected, that was intentional. The signs listing wait times at the beginning of ride queues purposefully inflate the numbers. That way, when a wait that was supposed to be 120 minutes goes by in 90, you feel like you have more time than you did before.

The final trick is something Disney parks are famous for: By incorporating the same level of production design found on the ride into the queue, Imagineers make waiting in line an engaging experience that has entertainment value of its own. The Tower of Terror queue in Disney World, which is modeled after a decrepit 1930s hotel lobby down to the cobwebs and the abandoned coffee cups, feels like it could be a movie set. Some ride lines even use special effects. While waiting to ride Star Wars: Ride of the Resistance in Galaxy's Edge, guests get to watch holograms and animatronics that set up the story of the ride. This strategy exploits the so-called dual-task paradigm, which makes the line feel as if it's going by faster by giving riders mental stimulation as they wait.

Tricky ride design is just one of Disney's secrets. Here are more behind-the-scenes facts about the beloved theme parks.

[h/t Popular Science]