Antibodies in Llama Blood Might Eliminate the Need for Yearly Flu Shots

iStock.com/AllenSphoto
iStock.com/AllenSphoto

Getting your yearly flu shot is an important way to protect yourself against the latest strains of the virus. But the annual practice can also be annoying, as evidenced by the more than half of all Americans who skip it. Now, BBC reports that scientists may have discovered the key to a perennial preventative flu treatment hiding in an unlikely source: llama blood.

According to a new paper published in the journal Science, the tiny antibodies produced by llamas are better equipped to fight the influenza virus than the larger ones found in humans. When the flu virus enters your body, specialized white blood cells called B lymphocytes make antibodies to attack it; they glob onto proteins on the outside of the virus, marking it so the immune system knows what to eradicate. But this only works if the shape of the antibody fits the proteins on the outside of the virus. If the exterior of the flu virus has mutated since your last flu shot, your body may not be able to recognize and stop it.

Llama antibodies work a bit differently. They're much smaller than humans', which means they can reach the core of an influenza virus—a.k.a. the part that looks the same from strain to strain. If scientists can make a human antibody that functions the same way, they will essentially develop a one-size-fits-all treatment that could continue to be effective as years progress.

For their study, researchers from the Scripps Institute in California made a synthetic antibody that borrowed elements from some of the strongest flu antibodies produced in llama blood. After wrapping the antibodies' genetic information in a harmless virus and infecting flu-sickened mice with it, the flu virus was stopped in almost every case. Only one of the 60 flu strains that were tested persisted, and it was one that doesn't infect humans.

This flu "vaccine" isn't really a vaccine at all—it's more like gene therapy. Unlike current flu shots, it doesn't have to train the body's immune system to be effective, which would make it an especially appealing option for people with weakened immune systems like elderly patients. But human trials still need to be completed before the promise of a stronger, longer-lasting flu treatment becomes a possibility.

[h/t BBC]

Nike Is Releasing a Durable Slip-On Sneaker Designed for Medical Professionals

monkeybusinessimages/iStock via Getty Images
monkeybusinessimages/iStock via Getty Images

Nike is known for releasing footwear that covers just about every activity under the moon—impact-absorbing running shoes, sleek soccer cleats, snazzy fashion statements, and so much more. Now, they’ve developed a sneaker for nurses, doctors, and other medical professionals who spend long shifts on their feet.

According to a press release, Nike sent designers to the OHSU Doernbecher Children’s Hospital in Portland, Oregon, where they learned from healthcare providers exactly what their jobs entail. Then, they used their findings to create the Nike Air Zoom Pulse, a “traditional clog made athletic.”

nike air zoom pulse
Nike

If you’ve ever gone sightseeing in a new city or even just taken a longer-than-expected afternoon stroll, you might have experienced firsthand that even your most comfortable walking shoes stop being so comfortable after a few miles of non-stop action—and nurses experience that type of exercise every time they go to work. During a regular 12-hour shift, a nurse might walk between four and five miles and sit for less than an hour. To account for that, the Nike Air Zoom Pulse features a full-rubber outsole, a flexible drop-in midsole, arch support, and a “heel fit so secure [that] it feels like a soft, snug hug.”

nike air zoom pulse
Nike

Since healthcare professionals also need a shoe durable enough to withstand spills of any kind, Nike coated the top of the Air Zoom Pulse with a polyurethane layer that’s easy to wipe down. It’s also a laceless slip-on, so people won’t have to worry about tripping on untied laces—and they’ll also be able to slip their shoes off for a quick nap in the staff room.

nike air zoom pulse
Nike

Six patients at the OHSU Doernbecher Children’s Hospital have contributed vibrant, colorful designs for the Air Zoom Pulse, which Nike will release for online orders (in versions that include its own colorways) starting December 7.

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10 Radiant Facts About Marie Curie

Photo Illustration by Mental Floss. Curie: Hulton Archive, Getty Images. Background: iStock
Photo Illustration by Mental Floss. Curie: Hulton Archive, Getty Images. Background: iStock

Born Maria Salomea Skłodowska in Poland in 1867, Marie Curie grew up to become one of the most noteworthy scientists of all time. Her long list of accolades is proof of her far-reaching influence, but not every stride she made in the fields of chemistry, physics, and medicine was recognized with an award. Here are some facts you might not know about the iconic researcher.

1. Marie Curie's parents were teachers.

Maria Skłodowska was the fifth and youngest child of two Polish educators. Her parents placed a high value on learning and insisted that all their children—including their daughters—receive a quality education at home and at school. Maria received extra science training from her father, and when she graduated from high school at age 15, she was first in her class.

2. Marie Curie had to seek out alternative education for women.

After collecting her high school diploma, Maria had hoped to study at the University of Warsaw with her sister, Bronia. Because the school didn't accept women, the siblings instead enrolled at the Flying University, a Polish college that welcomed female students. It was still illegal for women to receive higher education at the time so the institution was constantly changing locations to avoid detection from authorities. In 1891 Maria moved to Paris to live with her sister, where she enrolled at the Sorbonne to continue her education.

3. Marie Curie is the only person to win Nobel Prizes in two separate sciences.

Marie Curie and her husband, Pierre Curie, in 1902.
Marie Curie and her husband, Pierre Curie, in 1902.
Agence France Presse, Getty Images

In 1903, Marie Curie made history when she won the Nobel Prize in physics with her husband, Pierre, and with physicist Henri Becquerel for their work on radioactivity, making her the first woman to receive the honor. The second Nobel Prize she took home in 1911 was even more historic: With that win in the chemistry category, she became the first person to win the award twice. And she remains the only person to ever receive Nobel Prizes for two different sciences.

4. Marie Curie added two elements to the Periodic Table.

The second Nobel Prize Marie Curie received recognized her discovery and research of two elements: radium and polonium. The former element was named for the Latin word for ray and the latter was a nod to her home country, Poland.

5. Nobel Prize-winning ran in Marie Curie's family.

Marie Curie's daughter Irène Joliot-Curie, and her husband, Frédéric Joliot-Curie, circa 1940.
Marie Curie's daughter Irène Joliot-Curie, and her husband, Frédéric Joliot-Curie, circa 1940.
Central Press, Hulton Archive // Getty Images

When Marie Curie and her husband, Pierre, won their Nobel Prize in 1903, their daughter Irène was only 6 years old. She would grow up to follow in her parents' footsteps by jointly winning the Nobel Prize for chemistry with her husband, Frédéric Joliot-Curie, in 1935. They were recognized for their discovery of "artificial" radioactivity, a breakthrough made possible by Irène's parents years earlier. Marie and Pierre's other son-in-law, Henry Labouisse, who married their younger daughter, Ève Curie, accepted a Nobel Prize for Peace on behalf of UNICEF, of which he was the executive director, in 1965. This brought the family's total up to five.

6. Marie Curie did her most important work in a shed.

The research that won Marie Curie her first Nobel Prize required hours of physical labor. In order to prove they had discovered new elements, she and her husband had to produce numerous examples of them by breaking down ore into its chemical components. Their regular labs weren't big enough to accommodate the process, so they moved their work into an old shed behind the school where Pierre worked. According to Curie, the space was a hothouse in the summer and drafty in the winter, with a glass roof that didn't fully protect them from the rain. After the famed German chemist Wilhelm Ostwald visited the Curies' shed to see the place where radium was discovered, he described it as being "a cross between a stable and a potato shed, and if I had not seen the worktable and items of chemical apparatus, I would have thought that I was been played a practical joke."

7. Marie Curie's notebooks are still radioactive.

Marie Curie's journals
Hulton Archive, Getty Images

When Marie Curie was performing her most important research on radiation in the early 20th century, she had no idea of the effects it would have on her health. It wasn't unusual for her to walk around her lab with bottles of polonium and radium in her pockets. She even described storing the radioactive material out in the open in her autobiography. "One of our joys was to go into our workroom at night; we then perceived on all sides the feebly luminous silhouettes of the bottles of capsules containing our products […] The glowing tubes looked like faint, fairy lights."

It's no surprise then that Marie Curie died of aplastic anemia, likely caused by prolonged exposure to radiation, in 1934. Even her notebooks are still radioactive a century later. Today they're stored in lead-lined boxes, and will likely remain radioactive for another 1500 years.

8. Marie Curie offered to donate her medals to the war effort.

Marie Curie had only been a double-Nobel Laureate for a few years when she considered parting ways with her medals. At the start of World War I, France put out a call for gold to fund the war effort, so Curie offered to have her two medals melted down. When bank officials refused to accept them, she settled for donating her prize money to purchase war bonds.

9. Marie Curie developed a portable X-ray to treat soldiers.

Marie Curie circa 1930
Marie Curie, circa 1930.
Keystone, Getty Images

Marie's desire to help her adopted country fight the new war didn't end there. After making the donation, she developed an interest in x-rays—not a far jump from her previous work with radium—and it didn't take her long to realize that the emerging technology could be used to aid soldiers on the battlefield. Curie convinced the French government to name her Director of the Red Cross Radiology Service and persuaded her wealthy friends to fund her idea for a mobile x-ray machine. She learned to drive and operate the vehicle herself and treated wounded soldiers at the Battle of the Marne, ignoring protests from skeptical military doctors. Her invention was proven effective at saving lives, and ultimately 20 "petite Curies," as the x-ray machines were called, were built for the war.

10. Marie Curie founded centers for medical research.

Following World War I, Marie Curie embarked on a different fundraising mission, this time with the goal of supporting her research centers in Paris and Warsaw. Curie's radium institutes were the site of important work, like the discovery of a new element, francium, by Marguerite Perey, and the development of artificial radioactivity by Irène and Frederic Joliot-Curie. The centers, now known as Institut Curie, are still used as spaces for vital cancer treatment research today.

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