Pfizer's Coronavirus Vaccine Appears 90 Percent Effective in Early Review

The race for an effective coronavirus vaccine is showing signs of real success.
The race for an effective coronavirus vaccine is showing signs of real success.
Photo by Edward Jenner from Pexels

After months of work, projections, and predictions, one of the companies leading the race to produce a safe and effective vaccine against the coronavirus has announced the first tangible evidence of real-world efficacy. On Monday, drug manufacturer Pfizer announced that early trial results demonstrate their vaccine is widely effective in preventing infection.

According to The New York Times, Pfizer—which has partnered with German drug company BioNTech—has disclosed information from its ongoing phase III clinical trial that indicates their vaccine was 90 percent effective in healthy volunteers. The Food and Drug Administration, which is responsible for approving any potential vaccine in the U.S., has previously stated that 50 percent effectiveness would be the threshold for potential approval.

The press release provided by Pfizer revealed that 94 people in its 43,558-person trial were infected with coronavirus. The trial will continue until 164 participants have been infected, at which time another review will be conducted.

The early results should not be confused with a trial result, and they have yet to be published in a peer-reviewed medical journal. It’s also not clear how long immunity will last, and as more results come in, the percentage of effectiveness could change. The FDA would also require two months of safety data. Once that milestone is reached later in November, it would allow Pfizer to file for emergency-use authorization.

If the authorization is granted, Pfizer says it would be able to produce 50 million doses of the vaccine, which is given in two shots spaced 21 days apart, by the end of the year. Pfizer executives previously told The New York Times that 15 million to 20 million people could be immunized by then. The limited supply of vaccine would almost certainly be earmarked for at-risk populations like health care workers and the elderly.

The vaccine works by using genetic material known as messenger RNA (mRNA) to “tell” the body to create a protein in the coronavirus. The presence of this protein then triggers an immune system reaction. This approach is also used by Moderna for their vaccine candidate. While the results of their study have yet to be revealed, having a similar mechanism might boost their chances of having an effective vaccine.

Experts have long cautioned that having an effective vaccine is only part of the puzzle. A method of manufacturing and distribution will need to be implemented in order to transport the vaccine—which needs to be kept in extremely cold conditions—and get it to the general population. To that end, Pfizer has been making extensive preparations for delivery of the vaccine, including designing a shipping box that can keep the vaccine at -70°C (-94°F) for up to 10 days.

Reactions from the scientific community thus far have been cautiously optimistic. While final results are still needed, some are saying that these early results could provide a real pathway for a less restrictive 2021.

[h/t The New York Times]

12 Creative Ways to Spend Your FSA Money Before the Deadline

stockfour/iStock via Getty Images
stockfour/iStock via Getty Images

If you have a Flexible Spending Account (FSA), chances are, time is running out for you to use that cash. Depending on your employer’s rules, if you don’t spend your FSA money by the end of the grace period, you potentially lose some of it. Lost cash is never a good thing.

For those unfamiliar, an FSA is an employer-sponsored spending account. You deposit pre-tax dollars into the account, and you can spend that money on a number of health care expenses. It’s kind of like a Health Savings Account (HSA), but with a few big differences—namely, your HSA funds roll over from year to year, so there’s no deadline to spend it all. With an FSA, though, most of your funds expire at the end of the year. Bummer.

The good news is: The law allows employers to roll $500 over into the new year and also offer a grace period of up to two and a half months to use that cash (March 15). Depending on your employer, you might not even have that long, though. The deadline is fast approaching for many account holders, so if you have to use your FSA money soon, here are a handful of creative ways to spend it.

1. Buy some new shades.

Head to the optometrist, get an eye prescription, then use your FSA funds to buy some new specs or shades. Contact lenses and solution are also covered.

You can also buy reading glasses with your FSA money, and you don’t even need a prescription.

2. Try acupuncture.

Scientists are divided on the efficacy of acupuncture, but some studies show it’s useful for treating chronic pain, arthritis, and even depression. If you’ve been curious about the treatment, now's a good time to try it: Your FSA money will cover acupuncture sessions in some cases. You can even buy an acupressure mat without a prescription.

If you’d rather go to a chiropractor, your FSA funds cover those visits, too.

3. Stock up on staples.

If you’re running low on standard over-the-counter meds, good news: Most of them are FSA-eligible. This includes headache medicine, pain relievers, antacids, heartburn meds, and anything else your heart (or other parts of your body) desires.

There’s one big caveat, though: Most of these require a prescription in order to be eligible, so you may have to make an appointment with your doctor first. The FSA store tells you which over-the-counter items require a prescription.

4. Treat your feet.

Give your feet a break with a pair of massaging gel shoe inserts. They’re FSA-eligible, along with a few other foot care products, including arch braces, toe cushions, and callus trimmers.

In some cases, foot massagers or circulators may be covered, too. For example, here’s one that’s available via the FSA store, no prescription necessary.

5. Get clear skin.

Yep—acne treatments, toner, and other skin care products are all eligible for FSA spending. Again, most of these require a prescription for reimbursement, but don’t let that deter you. Your doctor is familiar with the rules and you shouldn’t have trouble getting a prescription. And, as WageWorks points out, your prescription also lasts for a year. Check the rules of your FSA plan to see if you need a separate prescription for each item, or if you can include multiple products or drug categories on a single prescription.

While we’re on the topic of faces, lip balm is another great way to spend your FSA funds—and you don’t need a prescription for that. There’s also no prescription necessary for this vibrating face massager.

6. Fill your medicine cabinet.

If your medicine cabinet is getting bare, or you don’t have one to begin with, stock it with a handful of FSA-eligible items. Here are some items that don’t require a prescription:

You can also stock up on first aid kits. You don’t need a prescription to buy those, and many of them come with pain relievers and other medicine.

7. Make sure you’re covered in the bedroom.

Condoms are FSA-eligible, and so are pregnancy tests, monitors, and fertility kits. Female contraceptives are also covered when you have a prescription.

8. Prepare for your upcoming vacation.

If you have a vacation planned this year, use your FSA money to stock up on trip essentials. For example:

9. Get a better night’s sleep.

If you have trouble sleeping, sleep aids are eligible, though you’ll need a prescription. If you want to try a sleep mask, many of them are eligible without a prescription. For example, there’s this relaxing sleep mask and this thermal eye mask.

For those nights you’re sleeping off a cold or flu, a vaporizer can make a big difference, and those are eligible, too (no prescription required). Bed warmers like this one are often covered, too.

Your FSA funds likely cover more than you realize, so if you have to use them up by the deadline, get creative. This list should help you get started, and many drugstores will tell you which items are FSA-eligible when you shop online.

10. Go to the dentist.

While basics like toothpaste and cosmetic procedures like whitening treatments aren’t FSA eligible, most of the expenses you incur at your dentist’s office are. That includes co-pays and deductibles as well as fees for cleanings, x-rays, fillings, and even the cost of braces. There are also some products you can buy over-the-counter without ever visiting the dentist. Some mouthguards that prevent you from grinding your teeth at night are eligible, as are cleaning solutions for retainers and dentures.

11. Try some new gadgets.

If you still have some extra cash to burn, it’s a great time to try some expensive high-tech devices that you’ve been curious about but might not otherwise want to splurge on. The list includes light therapy treatments for acne, vibrating nausea relief bands, electrical stimulation devices for chronic pain, cloud-connected stethoscopes, and smart thermometers.

12. Head to Amazon.

There are plenty of FSA-eligible items available on Amazon, including items for foot health, cold and allergy medication, eye care, and first-aid kits. Find out more details on how to spend your FSA money on Amazon here.

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Scientists Come Closer to Understanding COVID-19 'Cytokine Storms'

Science is closer to understanding what prompts severe COVID-19 illness.
Science is closer to understanding what prompts severe COVID-19 illness.
Photo by Artem Podrez from Pexels

Researchers are one step closer to understanding the mechanisms behind "cytokine storms," an immune system reaction that can cause severe COVID-19 symptoms in patients infected with the coronavirus. In a new paper published in the journal Cell, scientists from St. Jude Children's Research Hospital describe their identification of the specific cytokines, or small proteins, that are produced by the body in an effort to fight the virus but sometimes overreact and wind up causing damage, including inflammation, lung injury, and organ failure.

After examining the many different kinds of cytokines in the body, researchers determined that no single cytokine caused this inflammatory response. Instead, it appears to be a combination of two specific cytokines, dubbed tumor necrosis factor (TNF)-alpha and interferon (INF)-gamma, that work in collusion to cause inflammatory cell death.

By identifying these proteins as the culprit, researchers suggested that administering neutralizing antibodies and disrupting the protein pathways that promote cell death might present a new treatment method for COVID-19.

COVID-19 can prompt a "cytokine storm" that can cause severe symptoms.St. Jude Children's Research Hospital

"Understanding the pathways and mechanism driving this inflammation is critical to develop effective treatment strategies," co-author Thirumala-Devi Kanneganti, vice chair of St. Jude's department of immunology, said in a press release. "This research provides that understanding. We also identified the specific cytokines that activate inflammatory cell death pathways and have considerable potential for treatment of COVID-19 and other highly fatal diseases, including sepsis."

Thus far, this theory has only been tested in mice, which received neutralizing antibodies and were protected from severe COVID-19 symptoms. But in isolating the exact cytokines involved, it will likely be easier to locate an effective treatment, either from an existing drug or one developed specifically for the task. In time, researchers hope clinical trials of select drugs can be another tool in the fight against the virus.

[h/t PennLive]