On March 26, 1953, Dr. Jonas Salk went on CBS radio to announce his vaccine for poliomyelitis. He had worked for three years to develop the polio vaccine, attacking a disease that killed 3000 Americans in 1952 alone, along with 58,000 newly reported cases. Polio was a scourge, and had been infecting humans around the world for millennia. Salk's vaccine was the first practical way to fight it, and it worked—polio was officially eliminated in the U.S. in 1979.
Salk's method was to kill various strains of the polio virus, then inject them into a patient. The patient's own immune system would then develop antibodies to the dead virus, preventing future infection by live viruses. Salk's first test subjects were patients who had already had polio ... and then himself and his family. His research was funded by grants, which prompted him to give away the vaccine after it was fully tested.
Clinical trials of Salk's vaccine began in 1954. By 1955 the trials proved it was both safe and effective, and mass vaccinations of American schoolchildren followed. The result was an immediate reduction in new cases. Salk became a celebrity because his vaccine saved so many lives so quickly.
Salk's vaccine required a shot. In 1962, Dr. Albert Sabin unveiled an oral vaccine using attenuated (weakened but not killed) polio virus. Sabin's vaccine was hard to test in America in the late 1950s, because so many people had been inoculated using the Salk vaccine. (Sabin did much of his testing in the Soviet Union.) Oral polio vaccine, whether with attenuated or dead virus, is still the preferred method of vaccination today. Polio isn't entirely eradicated around the world, though we're very close.
Here's a vintage newsreel from the mid 1950s telling the story:
For more information on Dr. Jonas Salk and his work, click here.