Scorpions Use Acid and Protons to Make Their Stings More Painful

Mesobuthus martensii, also known as the Chinese golden scorpion.
Mesobuthus martensii, also known as the Chinese golden scorpion.
Dr. Shilong Yang

Scorpions are, like the rest of us, just trying to get by. Although, admittedly, the rest of us don't make highly sophisticated death-juice in our behinds. According to a new study, one species even uses acid to make its sting more painful. Scientists reported their findings in the journal Science Advances.

Venom is a little word that covers scores of different chemicals with different effects, each evolved to combat a certain type of predator or problem. Some are anticoagulants, which can cause death by blood loss. Some are neurotoxic, causing paralysis. Others cause excruciating pain—a fine deterrent for predators too large to be killed outright.

Scorpions in the Buthidae family make more than 100 different toxins, most of which we still don't understand. One such mysterious substance is a peptide called BmP01. The scientists who discovered this compound quickly figured out that it works by activating a pain pathway in the brain called TRPV1. It's the same one capsaicin uses to deliver a jolt of spice.

What they couldn't figure out was how BmP01 was so potent. Its effects on the brain were far more powerful than they should have been, given the teeny-tiny amount of the toxin a scorpion dispenses.

Something was beefing up BmP01's pain-producing powers.

Dr. Shilong Yang

To find out what it was, scientists combed through the chemistry of the remaining components of Buthidae venom. One quality stood out: The venom was unusually acidic.

The researchers realized that the acid allows the venom to shed protons. Under normal circumstances, a high dose of protons can penetrate a pain pathway's defenses. Here, BmP01 and protons act together to activate the pain receptor, creating a stronger response—and more intense pain—than either could have done alone.

This "one-two punch approach" is a brilliant adaptation, the researchers say.

"Animal toxins delivered in this acidic package must have undergone optimization through evolution to better perform their biological functions," they write. "We suggest that, in addition to using a cocktail of toxins, bimodal activation may represent another general survival strategy used by venomous animals."

Looking to Downsize? You Can Buy a 5-Room DIY Cabin on Amazon for Less Than $33,000

Five rooms of one's own.
Five rooms of one's own.
Allwood/Amazon

If you’ve already mastered DIY houses for birds and dogs, maybe it’s time you built one for yourself.

As Simplemost reports, there are a number of house kits that you can order on Amazon, and the Allwood Avalon Cabin Kit is one of the quaintest—and, at $32,990, most affordable—options. The 540-square-foot structure has enough space for a kitchen, a bathroom, a bedroom, and a sitting room—and there’s an additional 218-square-foot loft with the potential to be the coziest reading nook of all time.

You can opt for three larger rooms if you're willing to skip the kitchen and bathroom.Allwood/Amazon

The construction process might not be a great idea for someone who’s never picked up a hammer, but you don’t need an architectural degree to tackle it. Step-by-step instructions and all materials are included, so it’s a little like a high-level IKEA project. According to the Amazon listing, it takes two adults about a week to complete. Since the Nordic wood walls are reinforced with steel rods, the house can withstand winds up to 120 mph, and you can pay an extra $1000 to upgrade from double-glass windows and doors to triple-glass for added fortification.

Sadly, the cool ceiling lamp is not included.Allwood/Amazon

Though everything you need for the shell of the house comes in the kit, you will need to purchase whatever goes inside it: toilet, shower, sink, stove, insulation, and all other furnishings. You can also customize the blueprint to fit your own plans for the space; maybe, for example, you’re going to use the house as a small event venue, and you’d rather have two or three large, airy rooms and no kitchen or bedroom.

Intrigued? Find out more here.

[h/t Simplemost]

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A Wily Fox With a Passion for Fashion Stole More Than 100 Shoes From a Berlin Neighborhood

The smirk.
The smirk.
Brett Jordan, Unsplash

In Berlin, Germany, a fox has embarked on a crime spree that puts Dora the Explorer’s Swiper completely to shame.

CNN-News18 reports that residents of Zehlendorf, a locality in southeastern Berlin, spent weeks scratching their heads as shoes continued to disappear from their stoops and patios overnight. After posting about the mystery on a neighborhood watch site and reading accounts from various bewildered barefooters, a local named Christian Meyer began to think the thief might be a fox.

He was right. Meyer caught sight of the roguish robber with a mouthful of flip-flop and followed him to a field, where he found more than 100 stolen shoes. The fox appears to have an affinity for Crocs, but the cache also contained sandals, sneakers, a pair of rubber boots, and one black ballet flat, among other footwear. Unfortunately, according to BBC News, Meyer’s own vanished running shoe was nowhere to be seen.

Foxes are known for their playfulness, and it’s not uncommon for one to trot off with an item left unattended in a yard. Birmingham & Black Country Wildlife explains that foxes are drawn to “things that smell good,” which, to a fox, includes dog toys, balls, gardening gloves, and worn shoes. And if your former cat’s backyard gravesite is suddenly empty one day, you can probably blame a fox for that, too; they bury their own food to eat later, so a deceased pet is basically a free meal.

The fate of Zehlendorf’s furriest burglar remains unclear, but The Cut’s Amanda Arnold has a radical idea: that the residents simply let the fox keep what is obviously a well-curated collection.

[h/t CNN-News18]