Scientists Remove Disease-Causing Mutations from Human Embryos

iStock
iStock

Researchers have successfully edited the genes of viable human embryos to repair mutations that cause a dangerous heart condition. The team published their controversial research in the journal Nature.

The versatile gene-editing technique known as CRISPR-Cas9 is no stranger to headlines. Scientists have already used it to breed tiny pigs, detect disease, and even embed GIFs in bacteria. As our understanding of the process grows more advanced and sophisticated, many researchers have wondered how it could be applied to human beings.

For the new study, an international team of researchers fertilized healthy human eggs with sperm from men with a disease called hypertrophic cardiomyopathy, a condition that can lead to sudden death in young people. The mutation responsible for the disease affects a gene called MYBPC3. It’s a dominant mutation, which means that an embryo only needs one bad copy of the gene to develop the disease.

Or, considered another way, this means that scientists could theoretically remove the disease by fixing that one bad copy.

Eighteen hours after fertilizing the eggs, the researchers went back in and used CRISPR-Cas9 to snip out mutated MYBPC3 genes in some of the embryos and replace them with healthy copies. Three days later, they checked back in to see how their subjects—which were, at this point, still microscopic balls of cells—had fared.

The treatment seemed successful. Compared to subjects in the control group, a significant number of edited embryos appeared mutation- and disease-free. The researchers also found no evidence that their intervention had led to any unwanted new mutations, although it is possible that the mutations were there and overlooked.

Our ability to edit human genes is improving by the day. But, many ethicists argue, just because we can do it doesn’t mean that we should. The United States currently prohibits germline editing of human embryos by government-funded researchers. But there’s no law against such experimentation in privately funded projects like this one.

The same day the new study was published, an international committee of genetics experts issued a consensus statement advising against editing any embryo intended for implantation (pregnancy and birth).

"While germline genome editing could theoretically be used to prevent a child being born with a genetic disease, its potential use also raises a multitude of scientific, ethical, and policy questions,” Derek T. Scholes of the American Society of Human Genetics said in a statement. “These questions cannot all be answered by scientists alone, but also need to be debated by society."

Ethicists and sociologists are concerned by the slippery slope of trying to build a better human. Many people with chronic illness and disability live happy, complete lives and report that they’re limited more by discrimination than by any medical issues.

Disability studies expert Lennard Davis of the University of Illinois says we can’t separate scientific decisions from our society’s history of violence against, and oppression of, disabled and sick people.

“A lot of this terrific science and technology has to take into account that the assumption of what life is like for people who are different is based on prejudice against disability,” he told Nature in 2016.

Rosemary Garland-Thomson is co-director of the Disability Studies Initiative at Emory University. Speaking to Nature, she said we are at a cultural and ethical precipice: “At our peril, we are right now trying to decide what ways of being in the world ought to be eliminated.”

Amazon’s Big Fall Sale Features Deals on Electronics, Kitchen Appliances, and Home Décor

Dash/Keurig
Dash/Keurig

If you're looking for deals on items like Keurigs, BISSELL vacuums, and essential oil diffusers, it's usually pretty slim pickings until the holiday sales roll around. Thankfully, Amazon is starting these deals a little earlier with their Big Fall Sale, where customers can get up to 20 percent off everything from home decor to WFH essentials and kitchen gadgets. Now you won’t have to wait until Black Friday for the deal you need. Make sure to see all the deals that the sale has to offer here and check out our favorites below.

Electronics

Dash/Amazon

- BISSELL Lightweight Upright Vacuum Cleaner $170 (save $60)

- Dash Deluxe Air Fryer $80 (save $20)

- Dash Rapid 6-Egg Cooker $17 (save $3)

- Keurig K-Café Single Coffee Maker $169 (save $30)

- COMFEE Toaster Oven $29 (save $9)

- AmazonBasics 1500W Oscillating Ceramic Heater $31 (save $4)

Home office Essentials

HP/Amazon

- HP Neverstop Laser Printer $250 (save $30)

- HP ScanJet Pro 2500 f1 Flatbed OCR Scanner $274 (save $25)

- HP Printer Paper (500 Sheets) $5 (save $2)

- Mead Composition Books Pack of 5 Ruled Notebooks $11 (save $2)

- Swingline Desktop Hole Punch $7 (save $17)

- Officemate OIC Achieva Side Load Letter Tray $15 (save $7)

- PILOT G2 Premium Rolling Ball Gel Pens 12-Pack $10 (save $3)

Toys and games

Selieve/Amazon

- Selieve Toys Old Children's Walkie Talkies $17 (save $7)

- Yard Games Giant Tumbling Timbers $59 (save $21)

- Duckura Jump Rocket Launchers $11 (save $17)

- EXERCISE N PLAY Automatic Launcher Baseball Bat $14 (save $29)

- Holy Stone HS165 GPS Drones with 2K HD Camera $95 (save $40)

Home Improvement

DEWALT/Amazon

- DEWALT 20V MAX LED Hand Held Work Light $54 (save $65)

- Duck EZ Packing Tape with Dispenser, 6 Rolls $11 (save $6)

- Bissell MultiClean Wet/Dry Garage Auto Vacuum $111 (save $39)

- Full Circle Sinksational Sink Strainer with Stopper $5 (save $2)

Home Décor

NECA/Amazon

- A Christmas Story 20-Inch Leg Lamp Prop Replica by NECA $41 save $5

- SYLVANIA 100 LED Warm White Mini Lights $8 (save 2)

- Yankee Candle Large Jar Candle Vanilla Cupcake $17 (save $12)

- Malden 8-Opening Matted Collage Picture Frame $20 (save $8)

- Lush Decor Blue and Gray Flower Curtains Pair $57 (save $55)

- LEVOIT Essential Oil Diffuser $25 (save $5)

Sign Up Today: Get exclusive deals, product news, reviews, and more with the Mental Floss Smart Shopping newsletter!

This article contains affiliate links to products selected by our editors. Mental Floss may receive a commission for purchases made through these links.

100 Fascinating Facts About Earth

The best Spaceball.
The best Spaceball.
NASA

Did you know that there’s a place in the South Pacific Ocean called Point Nemo that’s farther from land than any other point on Earth? So far, in fact, that the closest humans are usually astronauts aboard the International Space Station. (And by the way: The map you’re about to look for Point Nemo on might not be entirely accurate; a certain amount of distortion occurs when trying to depict a 3D planet on a 2D surface.)

In this all-new episode of The List Show, Mental Floss editor-in-chief Erin McCarthy is journeying to the center of the Earth, and visiting its oceans, its atmosphere, and even space, in search of 100 facts about our endlessly fascinating planet.

The subjects that fall under the umbrella of “facts about Earth” are nearly as expansive as Earth itself. Geology, biology, astronomy, and cartography, are all fair game—and those are just a few of the many -ologies, -onomies, and -ographies you’ll learn about below. 

Press play to find out more Earth-shattering facts, and subscribe to the Mental Floss YouTube channel for more fact-filled videos here.