More Evidence to Suggest That Your Insomnia Is Genetic

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iStock

In 2016, a study on mice found that certain sleep traits, like insomnia, have genetic underpinnings. Several studies of human twins have also suggested that insomnia can be an inherited trait. Now, new research published in Molecular Psychiatry not only reinforces that finding, but also suggests that there may be a genetic link between insomnia and some other psychiatric and physical disorders, like depression and type 2 diabetes, as Psych Central alerts us.

Insomnia is particularly prevalent in populations of military veterans. For this study, researchers at VA San Diego Healthcare System analyzed questionnaire responses and blood samples from almost 33,000 new soldiers at the beginning of basic training, along with pre- and post-deployment surveys from nearly 8000 soldiers deployed to Afghanistan starting in early 2012. They conducted genome-wide association tests to determine the heritability of insomnia and links between insomnia and other disorders. The results were adjusted for the presence of major depression (since insomnia is a common symptom of depression).

The genotype data showed that insomnia disorder was highly heritable and pinpointed potential genes that may be involved. The study indicated that there's a strong genetic correlation between insomnia and major depression. (The two were distinct, though, meaning that the insomnia couldn't be totally explained by the depression.) They also found a significant genetic correlation between insomnia and type 2 diabetes.

Because the study relied on data from the U.S. military, the study doesn't have the most far-reaching sample—it was largely male and wasn't as racially diverse as it could have been. (While it analyzed responses from recruits from European, African, and Latino ancestry, there weren't enough Asian-American participants to analyze as a group.) The responses were also self-reported, which isn't always the most accurate data-collection method.

The genes indicated by this study could be used to develop new treatments for insomnia, but future studies will likely need to explore these questions within broader populations.

[h/t Psych Central]

The Reason Our Teeth Are So Sensitive to Pain

This woman's tooth pain is actually helping her avoid further damage.
This woman's tooth pain is actually helping her avoid further damage.
champja/iStock via Getty Images

On a good day, your teeth can chew through tough steak and split hard candy into pieces without you feeling a thing. But sometimes, something as simple as slurping a frosty milkshake can send a shock through your tooth that feels even more painful than stubbing your toe.

According to Live Science, that sensitivity is a defense mechanism we’ve developed to protect damaged teeth from further injury.

“If you eat something too hot or chew something too cold, or if the tooth is worn down enough where the underlying tissue underneath is exposed, all of those things cause pain,” Julius Manz, American Dental Association spokesperson and director of the San Juan College dental hygiene program, told Live Science. “And then the pain causes the person not to use that tooth to try to protect it a little bit more.”

Teeth are made of three layers: enamel on the outside, pulp on the inside, and dentin between the two. Pulp, which contains blood vessels and nerves, is the layer that actually feels pain—but that doesn’t mean the other two layers aren’t involved. When your enamel (which isn’t alive and can’t feel anything at all) is worn down, it exposes the dentin, a tissue that will then allow especially hot or cold substances to stimulate the nerves in the pulp. Pulp can’t sense temperature, so it interprets just about every stimulus as pain.

If you do have a toothache, however, pulp might not be the (only) culprit. The periodontal ligament, which connects teeth to the jawbone, can also feel pain. As Manz explains, that sore feeling people sometimes get because of an orthodontic treatment like braces is usually coming from the periodontal ligament rather than the pulp.

To help you avoid tooth pain in the first place, here are seven tips for healthier teeth.

[h/t Live Science]

Arrokoth, the Farthest, Oldest Solar System Object Ever Studied, Could Reveal the Origins of Planets

NASA/Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute/Roman Tkachenko
NASA/Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute/Roman Tkachenko

A trip to the most remote part of our solar system has revealed some surprising insights into the formation of our own planet. Three new studies based on data gathered on NASA's flyby of Arrokoth—the farthest object in the solar system from Earth and the oldest body ever studied—is giving researchers a better idea of how the building blocks of planets were formed, what Arrokoth's surface is made of, and why it looks like a giant circus peanut.

Arrokoth is a 21-mile-wide space object that formed roughly 4 billion years ago. Located past Pluto in the Kuiper Belt, it's received much less abuse than other primordial bodies that sit in asteroid belts or closer to the sun. "[The objects] that form there have basically been unperturbed since the beginning of the solar system," William McKinnon, lead author of one of the studies, said at a news briefing.

That means, despite its age, Arrokoth doesn't look much different today than when it first came into being billions of years ago, making it the perfect tool for studying the origins of planets.

In 2019, the NASA spacecraft New Horizons performed a flyby of Arrokoth on the edge of the solar system 4 billion miles away from Earth. The probe captured a binary object consisting of two connected lobes that were once separate fragments. In their paper, McKinnon and colleagues explain that Arrokoth "is the product of a gentle, low-speed merger in the early solar system."

Prior to these new findings, there were two competing theories into how the solid building blocks of planets, or planetesimals, form. The first theory is called hierarchical accretion, and it states that planetesimals are created when two separate parts of a nebula—the cloud of gas and space dust born from a dying star—crash into one another.

The latest observations of Arrokoth support the second theory: Instead of a sudden, violent collision, planetesimals form when gases and particles in a nebula gradually amass to the point where they become too dense to withstand their own gravity. Nearby components meld together gradually, and a planetesimal is born. "All these particles are falling toward the center, then whoosh, they make a big planetesimal. Maybe 10, 20, 30, 100 kilometers across," said McKinnon, a professor of Earth and planetary sciences at Washington University. This type of cloud collapse typically results in binary shapes rather than smooth spheroids, hence Arrokoth's peanut-like silhouette.

If this is the origin of Arrokoth, it was likely the origin of other planetesimals, including those that assembled Earth. "This is how planetesimal formation took place across the Kuiper Belt, and quite possibly across the solar system," New Horizons principal investigator Alan Stern said at the briefing.

The package of studies, published in the journal Science, also includes findings on the look and substance of Arrokoth. In their paper, Northern Arizona University planetary scientist Will Grundy and colleagues reveal that the surface of the body is covered in "ultrared" matter so thermodynamically unstable that it can't exist at higher temperatures closer to the sun.

The ultrared color is a sign of the presence of organic substances, namely methanol ice. Grundy and colleagues speculate that the frozen alcohol may be the product of water and methane ice reacting with cosmic rays. New Horizons didn't detect any water on the body, but the researchers say its possible that H2O was present but hidden from view. Other unidentified organic compounds were also found on Arrokoth.

New Horizon's flyby of Pluto and Arrokoth took place over the course of a few days. To gain a further understanding of how the object formed and what it's made of, researchers need to find a way to send a probe to the Kuiper Belt for a longer length of time, perhaps by locking it into the orbit of a larger body. Such a mission could tell us even more about the infancy of the solar system and the composition of our planetary neighborhood's outer limits.

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