8 Unexpected Activities People Have Done in MRI Scanners for Science

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In medicine, magnetic resonance imaging (MRI) uses powerful magnetic fields and radio waves to show what's happening inside the body, producing dynamic images of our internal organs. Using similar technology that tracks blood flow, functional magnetic resonance imaging (fMRI) scans can show neuroscientists neural activity, indicating what parts of the brain light up when, for instance, a person thinks of an upsetting memory or starts craving cocaine. Both require staying within a massive MRI machine for the length of the scan.

There's some controversy over how scientists interpret fMRI data in particular—fMRI studies are based on the idea that an increase of blood flow to a region of the brain means more cellular activity there, but that might not be a completely accurate measure, and a 2016 report found that fMRI studies may have stunning rates of false positives.

But we're not here to talk about results. We're here to talk about all the weird, weird things scientists have asked people to do in MRI machines so that they could look at their brains and bodies. From getting naked to going to the bathroom, people have been willing to do some unexpected activities in the name of science. Here are just a few of the oddest things that people have done in scanners at the behest of curious researchers.

1. SING OPERA

Researchers once invited world-famous opera singer Michael Volle to sing inside an MRI at the University of Freiburg in Germany. The baritone sang a piece from Richard Wagner's opera Tannhäuser as part of a 2016 study on how the vocal tract moves during singing at different pitches and while changing volume. The study asked 11 other professional singers with different voice types to participate as well. They found that the larynx rose with a singer's pitch, but got lower as the song got louder, and that certain factors, like how open their lips were, correlated more with how loud the singer was than how high they were singing. The scientists concluded that future research on the larynx and the physical aspects of singing should take loudness into consideration.

That study wasn't the first to take MRI images of singers. In 2015, researchers at the University of Illinois demonstrated their technique for recording dynamic MRI imaging of speech using video of U of I speech specialist Aaron Johnson singing "If I Only Had a Brain" from The Wizard of Oz.

2. REACT TO ROBOT-DINOSAUR ABUSE

Stills of a video in which a robot gets petted or beaten by a human
Stills from the videos participants watched of robot dinosaurs being treated kindly or unkindly.
Rosenthal-von der Pütten et al., Computers in Human Behavior (2014)

To test whether or not humans can feel empathy with robots for a 2013 study, researchers put participants into an fMRI machine and made them watch videos of humans and robotic dinosaurs. The videos either included footage of the human or robot being stroked or tickled, or the subject being beaten and choked. The brain scans showed similar activity for people viewing both videos, suggesting that people might be able to feel similar empathy for robots as for people.

3. PLAY VIDEO GAMES WITH A MEAN-SPIRITED A.I.

Two brain scans
Eisenberger et al., Science (2003)

To see whether the brain responds to emotional pain in similar ways to physical pain, researchers asked participants in a 2003 study to experience social rejection within an fMRI machine. During the scans, participants played a virtual ball-tossing game against two other players—whom they believed to be other study participants in other scanners—by watching a screen through goggles and pressing one of two keys to toss the ball to one of the other players. They were actually playing against a computer that was programmed to eventually exclude the human player. At some point during the game, the computer-controlled players stopped throwing the human player the ball, causing them to feel excluded and ignored. The researchers found that the excluded study subjects showed brain activation in regions similar to the ones seen in studies of physical pain.

4. POOP

Watching people poop through MRI imaging is a surprisingly common medical technique. It's called magnetic resonance defecography. Doctors use it to diagnose issues with rectal function, analyzing how the muscles of the pelvis are working and the cause of bowel issues. The scan involves having ultrasound jelly and a catheter inserted into your butt, donning a diaper, and crawling inside an MRI scanner. Then, on command, you clench your pelvic muscles in various ways as ordered by the doctor, eventually resulting in pooping out the ultrasound jelly and whatever else you might need to evacuate. No pressure.

5. HAVE SEX …

MRI of a woman before, pre-, and after orgasm
MRI images of a woman at rest, in a pre-orgasmic phase, and 20 minutes after orgasm (L–R)
Schultz et al. in BMJ, 1999

Scientists have also recorded MRI body scans of couples having sex. In the late '90s, Dutch researcher Pek Van Andel and his colleagues at the University Hospital Groningen asked eight couples to come into their lab on a Saturday and have sex in the tube of an MRI scanner in order to analyze how genitals fit together during heterosexual intercourse. Despite the surroundings, they apparently had a fine time. "The subjective level of sexual arousal of the participants, men and women, during the experiment was described afterwards as average," the study noted.

Meanwhile, other researchers are trying to capture scientific images of sex in different, sometimes even more awkward ways. For her 2008 book Bonk: The Curious Coupling Of Sex And Science, science writer Mary Roach and her husband had sex in a lab at University College London while a researcher stood next to them and held an ultrasound wand to her abdomen.

6. … AND HAVE ORGASMS

Scan of a woman's brain during orgasm
Wise et al., The Journal of Sexual Medicine (2017)

Scientists still don't know all that much about how orgasms work, so various studies have asked participants to come into the lab, lay down in an fMRI scanner, and stimulate themselves to orgasm. (A reporter at Inside Jersey went to Rutgers to take part in the university's orgasm research herself in 2010. She brought her own sex toy, but the lab was kind enough to provide the lube.)

Over the course of their work, Rutgers researchers have found that when people bring themselves to orgasm within an fMRI machine, it activates more than 30 brain systems, including ones that you wouldn't think would be involved in getting off, like the prefrontal cortex, which is associated with problem solving and judgment.

7. COMPOSE MUSIC

A musical score with just a few notes on it
Lu et al., Scientific Reports (2015)

Singers aren't the only music professionals to get inside an fMRI machine for science. For a study published in 2015, 17 young composers were asked to create a piece of music while Chinese researchers examined their brain activity. While all of them played the piano, they were asked to compose a piece for an instrument none of them know how to play—the zheng, a traditional Chinese string instrument. They were given a musical staff with just a few introductory notes already written as inspiration and asked to come up with something from there. As soon as they exited the scanner, they wrote down the notes they had imagined during the imaging process. The researchers found that the composers' visual and motor cortex showed less activity than usual, the opposite of what researchers have seen in studies of musical improvisation.

8. HAVE AN OUT-OF-BODY EXPERIENCE

Four brain scans with different areas of the brain lit up in red, yellow, and orange
Activated portions of the brain during an out-of-body experience
Smith and Messier, Frontiers in Human Neuroscience (2014)

In a 2014 study, psychologists at the University of Ottawa recruited an undergraduate student who reported that she could have out-of-body experiences at will to do so within the confines of an fMRI scanner.

"She was able to see herself rotating in the air above her body, lying flat, and rolling along with the horizontal plane," the researchers wrote. "She reported sometimes watching herself move from above but remained aware of her unmoving 'real' body."

She entered the scanner six times, reporting out-of-body experiences that included feeling as if she were above her body and spinning or rocking side-to-side. The researchers found that the experience activated regions of her brain associated with kinesthetic imagery, the feeling of visualizing movement (as athletes often do during training and competitions, for instance), and a deactivated the visual cortex.

'Lost Species' of Tiny, Rabbit-Sized Deer Photographed in Vietnam for the First Time in 30 Years

Global Wildlife Conservation
Global Wildlife Conservation

The silver-backed chevrotain, also called the Vietnamese mouse-deer, is elusive. It's so elusive that scientists had feared it was extinct after none had been photographed for decades. But as The Washington Post reports, the first images taken of the mammal in nearly 30 years prove that the species is still alive in the woods of Vietnam.

No larger than small dogs, chevrotains are the tiniest ungulates, or hoofed animals, on Earth. They have vampire-like fangs and skinny legs that support their bodies. Silver-backed chevrotains are characterized by the silver sheen of their tawny coat.

The tiny population native to Vietnam has been devastated by poachers in recent decades. That, and the animal's natural shyness, make it incredibly difficult to study. Before this most recent sighting, the last time scientists had recorded one was in 1990.

Global Wildlife Conservation, the Southern Institute of Ecology, and the Leibniz Institute for Zoo and Wildlife Research teamed up in hopes of documenting the lost species. Researchers interviewed residents and government forest rangers in the Vietnamese city of Nha Trang about the silver-backed chevrotain, looking for tips on where to find one. Residents said that while populations had been hit hard by hunting, the animals were still around.

Based on this local ecological knowledge, scientists set up three camera traps in the Vietnamese woods. In just five months, they captured 275 photographs of the little mouse-deer. They then installed 29 additional cameras and snapped 1881 new images in that same length of time.

“For so long this species has seemingly only existed as part of our imagination," Global Wildlife Conservation associate conservation scientist An Nguyen said in a statement. "Discovering that it is, indeed, still out there, is the first step in ensuring we don’t lose it again, and we’re moving quickly now to figure out how best to protect it.”

Now that a silver-backed chevrotain population has been located, researchers plan to conduct the first-ever comprehensive survey of the species. Once the data is collected, it will be used to build a plan for the species' survival.

[h/t The Washington Post]

The Great Tryptophan Lie: Eating Turkey Does Not Make You Tired

H. Armstrong Roberts/iStock via Getty Images
H. Armstrong Roberts/iStock via Getty Images

While you’re battling your cousins for the best napping spot after Thanksgiving dinner, feel free to use this as a diversion tactic: It’s a myth that eating turkey makes you tired.

It’s true that turkey contains L-Tryptophan, an amino acid involved in sleep. Your body uses it to produce a B vitamin called niacin, which generates the neurotransmitter serotonin, which yields the hormone melatonin, which helps regulate your sleeping patterns. However, plenty of other common foods contain comparable levels of tryptophan, including other poultry, meat, cheese, yogurt, fish, and eggs.

Furthermore, in order for tryptophan to produce serotonin in your brain, it first has to make it across the blood-brain barrier, which many other amino acids are also trying to do. To give tryptophan a leg up in the competition, it needs the help of carbohydrates. Registered dietitian Elizabeth Somer tells WebMD that the best way to boost serotonin is to eat a small, all-carbohydrate snack a little while after you’ve eaten something that contains tryptophan, and the carbs will help ferry the tryptophan from your bloodstream to your brain.

But Thanksgiving isn’t exactly about eating small, well-timed snacks. It’s more about heaps of potatoes, mountains of stuffing, and generous globs of gravy—and that, along with alcohol, is more likely the reason you collapse into a spectacular food coma after your meal. Overeating (especially of foods high in fat) means your body has to work extra hard to digest everything. To get the job done, it redirects blood to the digestive system, leaving little energy for anything else. And since alcohol is a central nervous system depressant, it also slows down your brain and other organs.

In short, you can still hold turkey responsible for your Thanksgiving exhaustion, but you should make sure it knows it can share the blame with the homestyle mac and cheese, spiked apple cider, and second piece of pumpkin pie.

[h/t WebMD]

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