What Is a Calorie?

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The word calorie carries a lot of weight. We know we're supposed to avoid too many of them, but things get more complicated after that. What, exactly, are calories, and how do I burn them?

THE SCIENCE OF THE CALORIE

A calorie is a unit of heat energy that fuels your body, making it possible to move, breathe, think, sleep—and even digest food to make more energy.

While there is some disagreement about who first coined the term calorie, we know the French chemist Antoine Lavoisier used it in experiments he conducted during the winter of 1782–1783. He used a device called a calorimeter to measure how much ice melted in a metal container due to the heat emitted by guinea pigs housed inside it. Over time, that measurement was refined by other scientists to mean the amount of energy needed to raise the temperature of a kilogram of water by 1°C—what's known as a kilocalorie.

The food calorie and a kilocalorie (kcal) are technically the same thing, but we use the term calorie rather than kilocalorie because of an American chemist named Wilbur Olin Atwater. In the late 1880s, Atwater traveled to Germany to study at physiologist Carl Voit's laboratory, where Voit was researching the nutritional value of food and animal feed. Inspired by that research, Atwater took measurements of different foods with a bomb calorimeter—a device that essentially measures the heat in food when burned—by having study participants eat, and then measuring and subtracting [PDF] the amount of heat leaving their bodies through respiration and waste. He used a respiration calorimeter to measure their breath and a bomb calorimeter to burn their poop, and from that calculated just how many calories were left in their bodies to be used. When writing about his research, Atwater used the word calorie (kcal wouldn't be used in America until 1894, when it was published in a physiology textbook).

Based on his experiments, Atwater created a system for calculating the calories that human bodies can get from our food. There are three types of food nutrients that deliver caloric energy—fats, proteins, and carbohydrates—and Atwater arrived at a caloric measurement of each: A fat gram has nine calories, while a gram of protein and a gram of carbohydrates each have four. That system was modified [PDF] by USDA scientists in 1973, but it's otherwise still the basis for how calories are calculated today.

WHAT HAPPENS TO A CALORIE IN YOUR BODY

When you eat, enzymes in the mouth, stomach, and intestine break down nutrients by turning fats into fatty acids, sugars into simple sugars, and proteins into amino acids. Then, using oxygen cells throughout your body, these components are broken down into energy—a process known as metabolism.

Most of the calories we burn each and every day are used just to keep our body functioning, with about half going toward powering our major organs—the brain, liver, kidneys, and heart. We use the rest for physical activity and the process of converting food to energy. Anything not used by the body is then stored, first in the liver and eventually as fat cells.

Some foods, like honey (carbohydrates), are easily digestible, whereas nuts (a mix of carbohydrates, fat, and protein) can't actually be fully digested at all. There are also digestibility differences within the same type of food. For example, in plants, older leaves tend to be sturdier (and therefore harder to digest) and less caloric than younger ones. Most significantly, especially in terms of human evolution, whenever we cook or process food, the body can get more calories as compared to that same food eaten raw. All of this has an impact on the amount of calories we can actually use.

There's no food you can eat to speed up the rate at which you burn calories (changes from foods like spicy peppers are fleeting), but factors like age and rapid, drastic weight loss can slow it down.

Building more muscle can increase your metabolic rate (although how much is debatable), since muscle requires more energy to function than fat does. And while cardiovascular exercise might not permanently boost your metabolism, it does burn calories; just how much depends on your weight and how vigorously you exercise.

Examples of higher calorie burning exercises include cycling and running, but almost every activity burns something, so you could potentially burn more calories throughout the day by consistently doing low-energy activities like gardening or pacing during a conference call than you would during 30 minutes of fast cycling.

CALORIES: A SCIENCE IN FLUX

We still use the Atwater system for calculating food calories, but it's far from perfect. For one thing, a USDA study found that people absorbed fewer calories from nuts than had been estimated under Atwater's system—a serving of almonds, for example, provided not 170 calories, but 129. There's some evidence that people tend to digest food at all sorts of different rates too, depending on the individual makeup of our gut bacteria, meaning that the absorption of calories may differ from person to person.

Scientists now believe the numbers on food labels are more of an estimate than a precise measurement. While companies are required to provide caloric information on food labels, the FDA doesn't specify exactly how those calories should be calculated. Some companies, like McDonald's, send their food to a lab for measurement, while others estimate the total by adding up the calorie count for each food component from the USDA's massive food composition database. As scientists continue to refine how we calculate calories, we'll come to have a better idea of the energy we can actually get from these different foods.

How Are Vaccines Made?

Eugeneonline/iStock via Getty Images
Eugeneonline/iStock via Getty Images

Vaccines have long been hailed as one of our greatest public health achievements. They can be made to protect us from infections with either viral or bacterial microbes. Measles and smallpox, for example, are viruses; Streptococcus pneumoniae is a bacterium that causes a range of diseases, including pneumonia, ear and sinus infections, and meningitis. Hundreds of millions of illnesses and deaths have been prevented due to vaccines that eradicated smallpox and significantly reduced polio and measles infections. However, some misunderstanding remains regarding how vaccines are made, and why some scary-sounding ingredients [PDF] are included in the manufacturing process.

The production of our vaccines has evolved a lot since the early days, when vaccination was potentially dangerous. Inoculating an individual with ground-up smallpox scabs usually led to a mild infection (called "variolation"), and protected them from acquiring the disease the "regular" way (via the air). But there was always a chance the infection could still be severe. When Edward Jenner introduced the first true vaccination with cowpox, protection from smallpox became safer, but there were still issues: The cowpox material could be contaminated with other germs, and sometimes was transmitted from one vaccinated person to another, leading to the inadvertent spread of blood-borne pathogens. We’ve come far in the last 200 years.

There are different kinds of vaccines, and each requires different processes to move from the laboratory to your physician's office. The key to all of them is production of one or more antigens—the portion of the microbe that triggers a host immune response.

Live Attenuated Vaccines and Dead, "Inactivated" Vaccines

There are several methods to produce antigens. One common technique is to grow a virus in a cell culture. Typically grown in large vats called bioreactors, living cells are inoculated with a virus and placed in a liquid growth medium that contains nutrients—proteins, amino acids, carbohydrates, essential minerals—that help the virus grow in the cells, producing thousands of copies of itself in each infected cell. At this stage the virus is also getting its own dose of protective medicine: antibiotics like neomycin or polymyxin B, which prevent bacterial and fungal contamination that could kill the cells serving as hosts for the virus.

Once a virus completes its life cycle in the host cell, the viruses are purified by separating them from the host cells and growth media, which are discarded. This is often done using several types of filters; the viruses are small and can pass through holes in the filter that trap larger host cells and cell debris.

This is how "live attenuated vaccines" are created. These vaccines contain viruses that have been modified so that they are no longer harmful to humans. Some of them are grown for many generations in cells that aren't human, such as chicken cells, so that they have mutated to no longer cause harm to humans. Others, like the influenza nasal mist, were grown at low temperatures until they lost the ability to replicate in the warmer temperatures of the lungs. Many of these vaccines you were probably given as a child: measles, mumps, rubella, and chickenpox.

Live attenuated vaccines replicate briefly in the body, triggering a strong—and long-lasting—response from your immune system. Because your immune system kicks into high gear at what it perceives to be a major threat, you need fewer doses of the vaccine for protection against these diseases. And unlike the harmful form of the virus, it is extremely unlikely (because they only replicate at low levels) that these vaccines will cause the host to develop the actual disease, or to spread it to other contacts. One exception is the live polio vaccine, which could spread to others and, extremely rarely, caused polio disease (approximately one case of polio from 3 million doses of the virus). For this reason, the live polio virus was discontinued in the United States in 2000.

Scientists use the same growth technique for "killed" or "inactivated" vaccines, but they add an extra step: viral death. Inactivated viruses are killed, typically via heat treatment or use of a chemical such as formaldehyde, which modifies the virus's proteins and nucleic acids and renders the virus unable to replicate. Inactivated vaccines include Hepatitis A, the injected polio virus, and the flu shot.

A dead virus can't replicate in your body, obviously. This means that the immune response to inactivated vaccines isn't as robust as it is with live attenuated vaccines; replication by the live viruses alerts many types of your immune cells of a potential invader, while killed vaccines primarily alert only one part of your immune system (your B cells, which produce antibodies). That's why you need more doses to achieve and maintain immunity.

While live attenuated vaccines were the primary way to make vaccines until the 1960s, concerns about potential safety issues, and the difficulty of making them, mean that few are attempting to develop new live attenuated vaccines today.

Combination, Bacterial, and Genetically Engineered Vaccines

Other vaccines aren't made of whole organisms at all, but rather bits and pieces of a microbe. The combination vaccine that protects against diphtheria, pertussis, and tetanus—all at once—is one example. This vaccine is called the DTaP for children, and Tdap for adults. It contains toxins (the proteins that cause disease) from diphtheria, pertussis, and tetanus bacteria that have been inactivated by chemicals. (The toxins are called "toxoids" once inactivated.) This protects the host—a.k.a. you, potentially—from developing clinical diphtheria and tetanus disease, even if you are exposed to the microorganisms. (Some viruses have toxins—Ebola appears to, for example—but they're not the key antigens, so they're not used for our current vaccines.)

As they do when developing live attenuated or inactivated vaccines, scientists who create these bacterial vaccines need some target bacteria to culture. But because the bacteria don't need a host cell to grow, they can be produced in simple nutrient broths by vaccine manufacturers. The toxins are then separated from the rest of the bacteria and growth media and inactivated for use as vaccines.

Similarly, some vaccines contain just a few antigens from a bacterial species. Vaccines for Streptococcus pneumoniae, Haemophilus influenzae type B, and Neisseria meningitidis all use sugars that are found on the outer part of the bacteria as antigens. These sugars are purified from the bacteria and then bound to another protein to enhance the immune response. The protein helps to recruit T cells in addition to B cells and create a more robust reaction.

Finally, we can also use genetic engineering to produce vaccines. We do this for Hepatitis B, a virus that can cause severe liver disease and liver cancer. The vaccine for it consists of a single antigen: the hepatitis B surface antigen, which is a protein on the outside of the virus. The gene that makes this antigen is inserted into yeast cells; these cells can then be grown in a medium similar to bacteria and without the need for cell culture. The hepatitis B surface antigen is then separated from the yeast and serves as the primary vaccine component.

Other Ingredients in Vaccines (and Why They're There)

Once you have the live or killed viruses, or purified antigens, sometimes chemicals need to be added to protect the vaccine or to make it work better. Adjuvants, such as aluminum salts, are a common additive; they help enhance the immune response to some antigens by keeping the antigen in contact with the cells of the immune system for a longer period of time. Vaccines for DTaP/Tdap, meningitis, pneumococcus, and hepatitis B all use aluminum salts as an adjuvant.

Other chemicals may be added as stabilizers, to help keep the vaccine working effectively even in extreme conditions (such as hot temperatures). Stabilizers can include sugars or monosodium glutamate (MSG). Preservatives can be added to prevent microbial growth in the finished product.

For many years, the most common preservative was a compound called thimerosal, which is 50 percent ethylmercury by weight. Ethylmercury doesn't stick around; your body quickly eliminates it via the gut and feces. (This is different from methylmercury, which accumulates in fish and can, at high doses, cause long-lasting damage in humans.) In 2001, thimerosal was removed from the vaccines given in childhood due to consumer concerns, but many studies have demonstrated its safety.

Finally, the vaccine is divided into vials for shipping to physicians, hospitals, public health departments, and some pharmacies. These can be single-dose or multi-dose vials, which can be used for multiple patients as long as they're prepared and stored away from patient treatment areas. Preservatives are important for multi-dose vials: bacteria and fungi are very opportunistic, and multiple uses increase the potential for contamination of the vaccine. This is why thimerosal is still used in some multi-dose influenza vaccines.

Though some of the vaccine ingredients sound worrisome, most of these chemicals are removed during multiple purification steps, and those that remain (such as adjuvants) are necessary for the vaccine's effectiveness, are present in very low levels, and have an excellent track record of safety.

The Science Behind Why the Earth Isn't Flat

Earth as captured from near the lunar horizon by the Lunar Reconnaissance Orbiter in 2015.
Earth as captured from near the lunar horizon by the Lunar Reconnaissance Orbiter in 2015.
NASA

On March 24, 2018, flat-earther Mike Hughes set out prove that the Earth is shaped like a Frisbee. The plan: Strap himself to a homemade steam-powered rocket and launch 52 miles into sky above California’s Mojave Desert, where he'd see Earth's shape with his own eyes.

It didn't matter that astronauts like John Glenn and Neil Armstrong had been to space and verified that the Earth is round; Hughes didn't believe them. According to The Washington Post, Hughes thought they were "merely paid actors performing in front of a computer-generated image of a round globe."

The attempt, ultimately, was a flop. He fell back to Earth with minor injuries after reaching 1875 feet—not even as high as the tip of One World Trade Center. For the cost of his rocket stunt ($20,000), Hughes could have easily flown around the world on a commercial airliner at 35,000 feet.

Hughes isn't alone in his misguided belief: Remarkably, thousands of years after the ancient Greeks proved our planet is a sphere, the flat-Earth movement seems to be gaining momentum. "Theories" abound on YouTube, and the flat-Earth Facebook page has some 194,000 followers.

Of course, the Earth isn't flat. It's a sphere. There is zero doubt about this fact in the real, round world. To say the evidence is overwhelming is an understatement.

HOT SPINNING BODIES

Not every celestial body is a sphere, but round objects are common in the universe: In addition to Earth and all other known large planets, stars and bigger moons are also ball-shaped. These objects, and billions of others, have the same shape because of gravity, which pulls everything toward everything else. All of that pulling makes an object as compact as it can be, and nothing is more compact than a sphere. Say, for example, you have a sphere of modeling clay that is exactly 10 inches in diameter. No part of the mass is more than 5 inches from the center. That's not the case with any other shape—some part of the material will be more than 5 inches from the center of the mass. A sphere is the smallest option.

Today the Earth is mostly solid with a liquid outer core, but when the planet was forming, some 4.5 billion years ago, it was very hot and behaved like more like a fluid—and was subject to the squishing effects of gravity.

And yet, the Earth isn't a perfect sphere; it bulges slightly at the equator. "Over a long time-scale, the Earth acts like a highly viscous fluid," says Surendra Adhikari, a geophysicist at the Jet Propulsion Laboratory in Pasadena, California. The Earth has been spinning since it was formed, and "if you have a spinning fluid, it will bulge out due to centrifugal forces." You can see evidence for this at the equator, where the Earth's diameter is 7926 miles—27 miles larger than at the poles (7899 miles). The difference is tiny—just one-third of 1 percent.

THE SHADOW KNOWS

The ancient Greeks figured out that Earth was a sphere 2300 years ago by observing the planet's curved shadow during a lunar eclipse, when the Earth passes between the Sun and the Moon. Some flat-Earth believers claim the world is shaped like a disk, perhaps with a wall of ice along the outer rim. (Why no one has ever seen this supposed wall, let alone crashed into it, remains unexplained.) Wouldn't a disk-shaped Earth also cast a round shadow? Well, it would depend on the orientation of the disk. If sunlight just happened to hit the disk face-on, it would have a round shadow. But if light hit the disk edge-on, the shadow would be a thin, straight line. And if the light fell at an oblique angle, the shadow would be a football–shaped ellipse. We know the Earth is spinning, so it can't present one side toward the Sun time after time. What we observe during lunar eclipses is that the planet's shadow is always round, so its shape has to be spherical.

The ancient Greeks also knew Earth's size, which they determined using the Earth's shape. In the 2nd century BCE, a thinker named Eratosthenes read that on a certain day, the people of Syene, in southern Egypt, reported seeing the Sun directly overhead at noon. But in Alexandria, in northern Egypt, on that same day at the same time, Eratosthenes had observed the Sun being several degrees away from overhead. If the Earth were flat, that would be impossible: The Sun would have to be the same height in the sky for observers everywhere, at each moment in time. By measuring the size of this angle, and knowing the distance between the two cities, Eratosthenes was able to calculate the Earth's diameter, coming up with a value within about 15 percent of the modern figure.

And when Columbus set sail from Spain in 1492, the question wasn't "Would he fall off the edge of the world?"—educated people knew the Earth was round—but rather, how long a westward voyage from Europe to Asia would take, and whether any new continents might be found along the way. During the Age of Exploration, European sailors noticed that, as they sailed south, "new" constellations came into view—stars that could never be seen from their home latitudes. If the world were flat, the same constellations would be visible from everywhere on the Earth's surface.

Finally, in 1522, Ferdinand Magellan's crew became the first people to circle the globe. Like Columbus, Magellan also set off from Spain, in 1519, heading west—and kept generally going west for the next three years. The expedition wound up back at the starting point (though without Magellan, who was killed during a battle in the Philippines). And speaking of ships and seafaring: One only needs to watch a tall ship sailing away from port to see that its hull disappears before the top of its mast. That happens because the ship is traveling along a curved surface; if the Earth were flat, the ship would just appear smaller and smaller, without any part of it slipping below the horizon.

THE EVIDENCE IS ALL AROUND (AND ALL ROUND)

But you don't need a ship to verify the Earth's shape. When the Sun is rising in, say, Moscow, it's setting in Los Angeles; when it's the middle of the night in New Delhi, the Sun is shining high in the sky in Chicago. These differences occur because the globe is constantly spinning, completing one revolution per day. If the Earth were flat, it would be daytime everywhere at once, followed by nighttime everywhere at once.

You also experience the Earth's roundness every time you take a long-distance flight. Jetliners fly along the shortest path between any two cities. "We use flight paths that are calculated on the basis of the Earth being round," Adhikari says. Imagine a flight from New York to Sydney: It would typically head northwest, toward Alaska, then southwest toward Australia. On the map provided in your airline's in-flight magazine, that might look like a peculiar path. But wrap a piece of string around a globe, and you'll see that it’s the shortest possible route.

"If the Earth were flat," Adhikari says, "the trajectory would be completely different." How different depends on which way the globe is sliced into a flattened map, but if it looked like it does on a Mercator-projection map, it might head east and pass over Africa.

Engineers and architects also take the Earth's curvature into account when building large structures. A good example is the towers that support long suspension bridges such as the Verrazano Narrows bridge in New York City. Its towers are slightly out of parallel with each other, the tops being more than 1.5 inches further apart than their bases. If the Earth were flat, the bottom of the towers would be separated by the exact same distance as the top of the towers; the planet's curvature forces the tops of the towers apart.

And for the last half-century, we've had eyewitness and photographic proof of the Earth's shape. In December 1968, the crew of Apollo 8 left Earth for the Moon. When they looked out of the Command Module windows, they saw a blue-and-white marble suspended against the blackness of space. On Christmas Eve, lunar module pilot William Anders snapped the famous "Earthrise" photograph. It gave us an awe-inspiring perspective of our round planet that was unprecedented in human history—but it wasn't a surprise to anyone.

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