14 Facts About Celiac Disease

iStock.com/fcafotodigital
iStock.com/fcafotodigital

Going gluten-free may be a modern diet trend, but people have been suffering from celiac disease—a chronic condition characterized by gluten intolerance—for centuries. Patients with celiac are ill-equipped to digest products made from certain grains containing gluten; wheat is the most common. In the short-term this can cause gastrointestinal distress, and in the long-term it can foster symptoms associated with early death.

Celiac diagnoses are more common than ever, which also means awareness of how to live with the condition is at an all-time high. Here are some things you might not know about celiac disease symptoms and treatments.

1. Celiac an autoimmune disease.

The bodies of people with celiac have a hostile reaction to gluten. When the protein moves through the digestive tract, the immune system responds by attacking the small intestine, causing inflammation that damages the lining of the organ. As this continues over time, the small intestine has trouble absorbing nutrients from other foods, which can lead to additional complications like anemia and osteoporosis.

2. You can get celiac disease from your parents.

Nearly all cases of celiac disease arise from certain variants of the genes HLA-DQA1 and HLA-DQB1. These genes help produce proteins in the body that allow the immune system to identify potentially dangerous foreign substances. Normally the immune system wouldn't label gliadin, a segment of the gluten protein, a threat, but due to mutations in these genes, the bodies of people with celiac treat gliadin as a hostile invader.

Because it's a genetic disorder, people with a first-degree relative (a sibling, parent, or child) with celiac have a 4 to 15 percent chance of having it themselves. And while almost all patients with celiac have these specific HLA-DQA1 and HLA-DQB1 variations, not everyone with the mutations will develop celiac. About 30 percent of the population has these gene variants, and only 3 percent of that group goes on to develop celiac disease.

3. Makeup might contribute to celiac disease symptoms.

People with celiac disease can’t properly process gluten, the protein naturally found in the grains like wheat, rye, and barley. Patients have to follow strict dietary guidelines and avoid most bread, pasta, and cereal, in order to manage their symptoms. But gluten isn’t limited to food products: It can also be found in some cosmetics. While makeup containing gluten causes no issues for many people with celiac, it can provoke rashes in others or lead to more problems if ingested. For those folks, gluten-free makeup is an option.

4. The name comes from 1st-century Greece.

A 1st-century Greek physician named Aretaeus of Cappadocia may have been the first person to describe celiac disease symptoms in writing [PDF]. He named it koiliakos after the Greek word koelia for abdomen, and he referred to people with the condition as coeliacs. In his description he wrote, “If the stomach be irretentive of the food and if it pass through undigested and crude, and nothing ascends into the body, we call such persons coeliacs.”

5. There are nearly 300 celiac disease symptoms.

Celiac disease may start in the gut, but it can be felt throughout the whole body. In children, the condition usually manifests as bloating, diarrhea, and abdominal discomfort, but as patients get older they start to experience more “non-classical” symptoms like anemia, arthritis, and fatigue. There are at least 281 symptoms associated with celiac disease, many of which overlap with other conditions and make celiac hard to diagnose. Other common symptoms of the disease include tooth discoloration, anxiety and depression, loss of fertility, and liver disorders. Celiac patients also have a greater chance of developing an additional autoimmune disorder, with the risk increasing the later in life the initial condition is diagnosed.

6. Some patients show no symptoms at all.

It’s not uncommon for celiac disease to be wrecking a patient’s digestive tract while showing no apparent symptoms. This form of the condition, sometimes called asymptomatic or “silent celiac disease,” likely contributes to part of the large number of people with celiac who are undiagnosed. People who are at high risk for the disease (the children of celiac sufferers, for example), or who have related conditions like type 1 diabetes and Down syndrome (both conditions that put patients at a greater risk for developing new autoimmune diseases) are encouraged to get tested for it even if they aren’t showing any signs.

7. It’s not the same as wheat sensitivity.

Celiac is often confused with wheat sensitivity, a separate condition that shares many symptoms with celiac, including gastrointestinal issues, depression, and fatigue. It’s often called gluten sensitivity or gluten intolerance, but because doctors still aren’t sure if gluten is the cause, many refer to it as non-celiac wheat sensitivity. There’s no test for it, but patients are often treated with the same gluten-free diet that’s prescribed to celiac patients.

8. It's not a wheat allergy either.

Celiac disease is often associated with wheat because it's one of the more common products containing gluten. While it's true that people with celiac can't eat wheat, the condition isn't a wheat allergy. Rather than reacting to the wheat, patients react to a specific protein that's found in the grain as well as others.

9. It can develop at any age.

Just because you don’t have celiac now doesn’t mean you’re in the clear for life: The disease can develop at any age, even in people who have tested negative for it previously. There are, however, two stages of life when symptoms are most likely to appear: early childhood (8 to 12 months) and middle adulthood (ages 40 to 60). People already genetically predisposed to celiac become more susceptible to it when the composition of their intestinal bacteria changes as they get older, either as a result of infection, surgery, antibiotics, or stress.

10. Not all grains are off-limits.

A gluten-free diet isn’t necessarily a grain-free diet. While it’s true that the popular grains wheat, barley, and rye contain gluten, there are plenty of grains and seeds that don’t and are safe for people with celiac to eat. These include quinoa, millet, amaranth, buckwheat, sorghum, and rice. Oats are also naturally gluten-free, but they're often contaminated with gluten during processing, so consumers with celiac should be cautious when buying them.

11. Celiac disease can be detected with a blood test.

Screenings for celiac disease used to be an involved process, with doctors monitoring patients’ reactions to their gluten-free diet over time. Today all it takes is a simple test to determine whether someone has celiac. People with the condition will have anti-tissue transglutaminase antibodies in their bloodstream. If a blood test confirms the presence of these proteins in a patient, doctors will then take a biopsy of their intestine to confirm the root cause.

12. The gluten-free diet doesn’t work for all patients.

Avoiding gluten is the most effective way to manage celiac disease, but the treatment doesn’t work 100 percent of the time. In up to a fifth of patients, the damaged intestinal lining does not recover even a year after switching to a gluten-free diet. Most cases of non-responsive celiac disease can be explained by people not following the diet closely enough, or by having other conditions like irritable bowel syndrome, lactose intolerance, or small intestine bacterial overgrowth that impede recovery. Just a small fraction of celiac disease sufferers don’t respond to a strict gluten-free diet and have no related conditions. These patients are usually prescribed steroids and immunosuppressants as alternative treatments.

13. If you don’t have celiac, gluten probably won’t hurt you.

The gluten-free diet trend has exploded in popularity in recent years, and most people who follow it have no medical reason to do so. Going gluten-free has been purported to do everything from help you lose weight to treat autism—but according to doctors, there’s no science behind these claims. Avoiding gluten may help some people feel better and more energetic because it forces them to cut heavily processed junk foods out of their diet. In such cases it’s the sugar and carbs that are making people feel sluggish—not the gluten protein. If you don’t have celiac or a gluten sensitivity, most experts recommend saving yourself the trouble by eating healthier in general rather than abstaining from gluten.

14. The numbers are growing.

A 2009 study found that four times as many people have celiac today than in the 1950s, and the spike can’t be explained by increased awareness alone. Researchers tested blood collected at the Warren Air Force Base between 1948 and 1954 and compared them to fresh samples from candidates living in one Minnesota county. The results supported the theory that celiac has become more prevalent in the last half-century. While experts aren’t exactly sure why the condition is more common today, it may have something to do with changes in how wheat is handled or the spread of gluten into medications and processed foods.

Looking to Downsize? You Can Buy a 5-Room DIY Cabin on Amazon for Less Than $33,000

Five rooms of one's own.
Five rooms of one's own.
Allwood/Amazon

If you’ve already mastered DIY houses for birds and dogs, maybe it’s time you built one for yourself.

As Simplemost reports, there are a number of house kits that you can order on Amazon, and the Allwood Avalon Cabin Kit is one of the quaintest—and, at $32,990, most affordable—options. The 540-square-foot structure has enough space for a kitchen, a bathroom, a bedroom, and a sitting room—and there’s an additional 218-square-foot loft with the potential to be the coziest reading nook of all time.

You can opt for three larger rooms if you're willing to skip the kitchen and bathroom.Allwood/Amazon

The construction process might not be a great idea for someone who’s never picked up a hammer, but you don’t need an architectural degree to tackle it. Step-by-step instructions and all materials are included, so it’s a little like a high-level IKEA project. According to the Amazon listing, it takes two adults about a week to complete. Since the Nordic wood walls are reinforced with steel rods, the house can withstand winds up to 120 mph, and you can pay an extra $1000 to upgrade from double-glass windows and doors to triple-glass for added fortification.

Sadly, the cool ceiling lamp is not included.Allwood/Amazon

Though everything you need for the shell of the house comes in the kit, you will need to purchase whatever goes inside it: toilet, shower, sink, stove, insulation, and all other furnishings. You can also customize the blueprint to fit your own plans for the space; maybe, for example, you’re going to use the house as a small event venue, and you’d rather have two or three large, airy rooms and no kitchen or bedroom.

Intrigued? Find out more here.

[h/t Simplemost]

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10 Facts About Real Genius On Its 35th Anniversary

Val Kilmer stars in Martha Coolidge's Real Genius (1985).
Val Kilmer stars in Martha Coolidge's Real Genius (1985).
Sony Pictures Home Entertainment

In an era where nerd is a nickname given by and to people who have pretty much any passing interest in popular culture, it’s hard to imagine the way old-school nerds—people with serious and socially-debilitating obsessions—were once ostracized. Computers, progressive rock, and role-playing games (among a handful of other 1970s- early '80s developments) created a path from which far too many of the lonely, awkward, and conventionally undateable would never return. But in the 1980s, movies transformed these oddballs into underdogs and antiheroes, pitting them against attractive, moneyed, successful adversaries for the fate of handsome boys and pretty girls, cushy jobs, and first-place trophies.

The 1985 film Real Genius ranked first among equals from that decade for its stellar cast, sensitive direction, and genuine nerd bona fides. Perhaps fittingly, it sometimes feels overshadowed, and even forgotten, next to broader, bawdier (and certainly now, more problematic) films from the era like Revenge of the Nerds and Weird Science. But director Martha Coolidge delivered a classic slobs-versus-snobs adventure that manages to view the academically gifted and socially maladjusted with a greater degree of understanding and compassion while still delivering plenty of good-natured humor.

As the movie commemorates its 35th anniversary, we're looking back at the little details and painstaking efforts that make it such an enduring portrait not just of ‘80s comedy, but of nerdom itself.

1. Producer Brian Grazer wanted Valley Girl director Martha Coolidge to direct Real Genius. She wasn’t sure she wanted to.

Following the commercial success of 1984’s Revenge of the Nerds, there was an influx of bawdy scripts that played upon the same idea, and Real Genius was one of them. In 2011, Coolidge told Kickin’ It Old School that the original script for Real Genius "had a lot of penis and scatological jokes," and she wasn't interested in directing a raunchy Nerds knock-off. So producer Brian Grazer enlisted PJ Torokvei (SCTV) and writing partners Babaloo Mandel and Lowell Ganz (Splash, City Slickers) to refine the original screenplay, and then gave Coolidge herself an opportunity to polish it before production started. “Brian's original goal, and mine, was to make a film that focused on nerds as heroes," Coolidge said. "It was ahead of its time."

2. Martha Coolidge’s priority was getting the science in Real Genius right—or at least as right as possible.

In the film, ambitious professor Jerry Hathaway (William Atherton) recruits high-achieving students at the fictional Pacific Technical University (inspired by Caltech) to design and build a laser capable of hitting a human-sized target from space. Coolidge researched the subject thoroughly, working with academic, scientific, and military technicians to ensure that as many of the script and story's elements were correct. Moreover, she ensured that the dialogue would hold up to some scrutiny, even if building a laser of the film’s dimensions wasn’t realistic (and still isn’t today).

3. One element of Real Genius that Martha Coolidge didn’t base on real events turned out to be truer than expected.

From the beginning, the idea that students were actively being exploited by their teacher to develop government technology was always fictional. But Coolidge learned that art and life share more in common than she knew at the time. “I have had so many letters since I made Real Genius from people who said, 'Yes, I was involved in a program and I didn’t realize I was developing weapons,'" she told Uproxx in 2015. “So it was a good guess and turned out to be quite accurate.”

4. Val Kilmer walked into his Real Genius audition already in character—and it nearly cost him the role.

After playing the lead in Top Secret!, Val Kilmer was firmly on Hollywood’s radar. But when he met Grazer at his audition for Real Genius, Kilmer decided to have some fun at the expense of the guy who would decide whether or not he’d get the part. "The character wasn't polite," Kilmer recalled to Entertainment Weekly in 1995. "So when I shook Grazer's hand and he said, 'Hi, I'm the producer,' I said, 'I'm sorry. You look like you're 12 years old. I like to work with men.'"

5. The filmmakers briefly considered using an actual “real genius” to star in Real Genius.

Among the performers considered to play Mitch, the wunderkind student who sets the movie’s story in motion, was a true genius who graduated college at 14 and was starting law school. Late in the casting process, they found their Mitch in Gabriel Jarrett, who becomes the third generation of overachievers (after Kilmer’s Chris and Jon Gries’s Lazlo Hollyfeld) whose talent Hathaway uses to further his own professional goals.

6. Real Genius's female lead inadvertently created a legacy for her character that would continue in animated form.

Michelle Meyrink, Gabriel Jarret, Val Kilmer, and Mark Kamiyama in Real Genius (1985).Sony Pictures Home Entertainment

Michelle Meyrink was a staple of a number of ‘80s comedies, including Revenge of the Nerds. Playing Jordan in Real Genius, she claims to “never sleep” and offers a delightful portrait of high-functioning attention-deficit disorder with a chipper, erratic personality. Disney’s Chip 'n Dale: Rescue Rangers co-creator Tad Stones has confirmed that her character went on to inspire the character of Gadget Hackwrench.

7. A Real Genius subplot, where a computer programmer is gaming a Frito-Lay contest, was based on real events.

In the film, Jon Gries (Napoleon Dynamite) plays Lazlo Hollyfeld, a reclusive genius from before Chris and Mitch’s time who lives in a bunker beneath their dorm creating entries to a contest with no restrictions where he eventually wins more than 30 percent of the prizes. In 1969, students from Caltech tried a similar tactic with Frito-Lay to game the odds. But in 1975, three computer programmers used an IBM to generate 1.2 million entries in a contest for McDonald’s, where they received 20 percent of the prizes (and a lot of complaints from customers) for their effort.

8. One of Real Genius's cast members went on to write another tribute to nerds a decade later.

Dean Devlin, who co-wrote Stargate and Independence Day with Roland Emmerich, plays Milton, another student at Pacific Tech who experiences a memorable meltdown in the rush up to finals.

9. The popcorn gag that ends Real Genius isn’t really possible, but they used real popcorn to simulate it.

At the end of the film, Chris and Mitch build a giant Jiffy Pop pack that the laser unleashes after they redirect its targeting system. The resulting popcorn fills Professor Hathaway’s house as an act of revenge. MythBusters took pains to recreate this gag in a number of ways, but quickly discovered that it wouldn’t work; even at scale, the popcorn just burns in the heat of a laser.

To pull off the scene in the film, Coolidge said that the production had people popping corn for six weeks of filming in order to get enough for the finale. After that, they had to build a house that they could manipulate with hydraulics so that the popcorn would “explode” out of every doorway and window.

10. Real Genius was the first movie to be promoted on the internet.

A week before Real Genius opened, promoters set up a press conference at a computer store in Westwood, California. Coolidge and members of the cast appeared to field questions from press from across the country—connected via CompuServe. Though the experience was evidently marred by technical problems (this was the mid-1980s, after all), the event marked the debut of what became the online roundtable junket.