How an Early Female Travel Writer Became an Immunization Pioneer

Lady Mary Wortley Montagu by A. Devéria
Lady Mary Wortley Montagu by A. Devéria

Lady Mary Wortley Montagu was a British aristocrat, feminist, and writer who was famed for her letters. If that were all she did, she would be a slightly obscure example of a travel writer and early feminist. But she was also an important public health advocate who is largely responsible for the adoption of inoculation against smallpox—one of the earliest forms of immunization—in England.

Smallpox was a scourge right up until the mid-20th century. Caused by two strains of Variola virus, the disease had a mortality rate of up to 35 percent. If you lived, you were left with unsightly scars, and possible complications such as severe arthritis and blindness.

Lady Montagu knew smallpox well: Her brother died of it at the age of 20, and in late 1715, she contracted the disease herself. She survived, but her looks did not; she lost her eyelashes and was left with deeply pitted skin on her face.

When Lady Montagu’s husband, Edward Wortley Montagu, was appointed ambassador to Turkey the year after her illness, she accompanied him and took up residence in Constantinople (now Istanbul). The lively letters she wrote home described the world of the Middle East to her English friends and served for many as an introduction to Muslim society.

One of the many things Lady Montagu wrote home about was the practice of variolation, a type of inoculation practiced in Asia and Africa likely starting around the 15th or 16th century. In variolation, a small bit of a pustule from someone with a mild case of smallpox is placed into one or more cuts on someone who has not had the disease. A week or so later, the person comes down with a mild case of smallpox and is immune to the disease ever after.

Lady Montagu described the process in a 1717 letter:

"There is a set of old women, who make it their business to perform the operation, every autumn, in the month of September, when the great heat is abated. People send to one another to know if any of their family has a mind to have the small-pox: they make parties for this purpose, and when they are met (commonly fifteen or sixteen together) the old woman comes with a nuts-hell full of the matter of the best sort of small-pox, and asks what veins you please to have opened. She immediately rips open that you offer to her with a large needle (which gives you no more pain than a common scratch), and puts into the vein as much matter as can lye upon the head of her needle, and after that binds up the little wound with a hollow bit of shell; and in this manner opens four or five veins. . . . The children or young patients play together all the rest of the day, and are in perfect health to the eighth. Then the fever begins to seize them, and they keep their beds two days, very seldom three. They have very rarely above twenty or thirty in their faces, which never mark; and in eight days' time they are as well as before their illness."

So impressed was Lady Montagu by the effectiveness of variolation that she had a Scottish doctor who worked at the embassy, Charles Maitland, variolate her 5-year-old son in 1718 with the help of a local woman. She returned to England later that same year. In 1721, a smallpox epidemic hit London, and Montagu had Maitland (who by then had also returned to England) variolate her 4-year-old daughter in the presence of several prominent doctors. Maitland later ran an early version of a clinical trial of the procedure on six condemned inmates in Newgate Prison, who were promised their freedom if they took part in the experiment. All six lived, and those later exposed to smallpox were immune. Maitland then repeated the experiment on a group of orphaned children with the same results.

A painting of Lady Mary Wortley Montagu with her son, Edward Wortley Montagu, and attendants
Lady Mary Wortley Montagu with her son, Edward Wortley Montagu, and attendants
Jean-Baptiste Vanmour, Art UK // CC BY-NC-ND

But the idea of purposely giving someone a disease was not an easy sell, especially since about 2 or 3 percent of people who were variolated still died of smallpox (either because the procedure didn’t work, or because they caught a different strain than the one they had been variolated with). In addition, variolated people could also spread the disease while they were infectious. Lady Montagu also faced criticism because the procedure was seen as “Oriental,” and because of her gender.

But from the start, Lady Montagu knew that getting variolation accepted would be an uphill battle. In the same letter as her first description of the practice, she wrote:

"I am patriot enough to take pains to bring this useful invention into fashion in England; and I should not fail to write to some of our doctors very particularly about it, if I knew any one of them that I thought had virtue enough to destroy such a considerable branch of their revenue for the good of mankind. But that distemper is too beneficial to them, not to expose to all their resentment the hardy wight that should undertake to put an end to it. Perhaps, if I live to return, I may, however, have courage to war with them."

As promised, Lady Montagu promoted variolation enthusiastically, encouraging the parents in her circle, visiting convalescing patients, and publishing an account of the practice in a London newspaper. Through her influence, many people, including members of the royal family, were inoculated against smallpox, starting with two daughters of the Princess of Wales in 1722. Without her advocacy, scholars say, variolation might never have caught on and smallpox would have been an even greater menace than it was. The famed poet Alexander Pope said that for her, immortality would be "a due reward" for "an action which all posterity may feel the advantage of," namely the "world’s being freed from the future terrors of the small-pox."

Variolation was performed in England for another 70 years, until Edward Jenner introduced vaccination using cowpox in 1796. Vaccination was instrumental in finally stopping smallpox: In 1980, it became the first (and so far, only) human disease to be completely eradicated worldwide.

This article was republished in 2019.

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6 Amazing Facts About Sally Ride

U.S. National Archives and Records Administration, Public Domain, Wikimedia Commons
U.S. National Archives and Records Administration, Public Domain, Wikimedia Commons

You know Sally Ride as the first American woman to travel into space. But here are six things you might not know about the groundbreaking astronaut, who was born on May 26, 1951.

1. Sally Ride proved there is such thing as a stupid question.

When Sally Ride made her first space flight in 1983, she was both the first American woman and the youngest American to make the journey to the final frontier. Both of those distinctions show just how qualified and devoted Ride was to her career, but they also opened her up to a slew of absurd questions from the media.

Journalist Michael Ryan recounted some of the sillier questions that had been posed to Ride in a June 1983 profile for People. Among the highlights:

Q: “Will the flight affect your reproductive organs?”
A: “There’s no evidence of that.”

Q: “Do you weep when things go wrong on the job?”
A: “How come nobody ever asks (a male fellow astronaut) those questions?"

Forget going into space; Ride’s most impressive achievement might have been maintaining her composure in the face of such offensive questions.

2. Had she taken Billie Jean King's advice, Sally Ride might have been a professional tennis player.

When Ride was growing up near Los Angeles, she played more than a little tennis, and she was seriously good at it. She was a nationally ranked juniors player, and by the time she turned 18 in 1969, she was ranked 18th in the whole country. Tennis legend Billie Jean King personally encouraged Ride to turn pro, but she went to Swarthmore instead before eventually transferring to Stanford to finish her undergrad work, a master’s, and a PhD in physics.

King didn’t forget about the young tennis prodigy she had encouraged, though. In 1984 an interviewer playfully asked the tennis star who she’d take to the moon with her, to which King replied, “Tom Selleck, my family, and Sally Ride to get us all back.”

3. Home economics was not Sally Ride's best subject.

After retiring from space flight, Ride became a vocal advocate for math and science education, particularly for girls. In 2001 she founded Sally Ride Science, a San Diego-based company that creates fun and interesting opportunities for elementary and middle school students to learn about math and science.

Though Ride was an iconic female scientist who earned her doctorate in physics, just like so many other youngsters, she did hit some academic road bumps when she was growing up. In a 2006 interview with USA Today, Ride revealed her weakest subject in school: a seventh-grade home economics class that all girls had to take. As Ride put it, "Can you imagine having to cook and eat tuna casserole at 8 a.m.?"

4. Sally Ride had a strong tie to the Challenger.

Ride’s two space flights were aboard the doomed shuttle Challenger, and she was eight months deep into her training program for a third flight aboard the shuttle when it tragically exploded in 1986. Ride learned of that disaster at the worst possible time: she was on a plane when the pilot announced the news.

Ride later told AARP the Magazine that when she heard the midflight announcement, she got out her NASA badge and went to the cockpit so she could listen to radio reports about the fallen shuttle. The disaster meant that Ride wouldn’t make it back into space, but the personal toll was tough to swallow, too. Four of the lost members of Challenger’s crew had been in Ride’s astronaut training class.

5. Sally Ride had no interest in cashing in on her worldwide fame.

A 2003 profile in The New York Times called Ride one of the most famous women on Earth after her two space flights, and it was hard to argue with that statement. Ride could easily have cashed in on the slew of endorsements, movie deals, and ghostwritten book offers that came her way, but she passed on most opportunities to turn a quick buck.

Ride later made a few forays into publishing and endorsements, though. She wrote or co-wrote more than a half-dozen children’s books on scientific themes, including To Space and Back, and in 2009 she appeared in a print ad for Louis Vuitton. Even appearing in an ad wasn’t an effort to pad her bank account, though; the ad featured an Annie Leibovitz photo of Ride with fellow astronauts Buzz Aldrin and Jim Lovell gazing at the moon and stars. According to a spokesperson, all three astronauts donated a “significant portion” of their modeling fees to Al Gore’s Climate Project.

6. Sally Ride was the first openly LGBTQ astronaut.

Ride passed away on July 23, 2012, at the age of 61, following a long (and very private) battle with pancreatic cancer. While Ride's brief marriage to fellow astronaut Steve Hawley was widely known to the public (they were married from 1982 to 1987), it wasn't until her death that Ride's longtime relationship with Tam O'Shaughnessy—a childhood friend and science writer—was made public. Which meant that even in death, Ride was still changing the world, as she is the world's first openly LGBTQ astronaut.