12 Facts About the Gallbladder

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Don't feel too bad if you forgot you have a gallbladder—it's one of those body parts that people tend to ignore unless there's a problem. Here's a refresher: It's that small pouch beneath the liver whose primary function is to store bile, which helps you digest fats. So the next time you wolf down a Quarter Pounder with cheese, you can thank your gallbladder for doing its part. Here are a few other things you should know.

1. IT’S THE SIZE OF A SMALL PEAR, AND IT LOOKS LIKE ONE, TOO.

Right before you take your first bite of pizza, your gallbladder is full of bile—an alkaline fluid that's produced in the liver, transported to the gallbladder, and then released into the small intestine to help break down fat and bilirubin, a product of dead red blood cells. The organ can hold the equivalent of a shot glass of the yellow-green liquid, which causes it to swell up to the size of a small pear.

When you eat certain foods—especially fatty ones—the gallbladder releases the bile and deflates like a balloon. Although most gallbladders are roughly 1 inch wide and 3 inches long, there are notable exceptions. In 2017, a gallbladder removed from a woman in India measured nearly a foot long, making it the longest gallbladder in the world.

2. YOU CAN LIVE WITHOUT IT.

You don’t need your gallbladder to live a full and healthy life. Just ask British playwright Mark Ravenhill, who wrote an account for the BBC about getting his gallbladder removed after a gallstone—a solid object made of cholesterol or calcium salts and bilirubin—had moved painfully into his pancreas. "'The gallbladder's completely useless,'" Ravenhill recalled his doctor explaining. "'If it's going to be a problem, best just to take it out.'"

In addition to preventing more gallstones from forming, a physician may recommend that a patient’s gallbladder be removed due to other diseases, like cholecystitis (inflammation of the gallbladder) and cancer. In most cases, removing it doesn’t affect digestion, but there can be some complications. "People can certainly live without one, but they do have to watch their fat intake," says Ed Zuchelkowski, an anatomist and biology professor at California University of Pennsylvania. People who don't have gallbladders still produce bile, but it flows directly from the liver to the small intestine. The only difference is that "you would not have as much bile readily available to release," Zuchelkowski tells Mental Floss, which could cause minor problems like diarrhea if you're eating fatty foods.

3. OUR HUNTER-GATHERER ANCESTORS MAY HAVE NEEDED IT MORE THAN WE DO.

"[The gallbladder] probably was more important to people in days when they would eat fewer meals and larger meals," Zuchelkowski says. This was generally the situation that our hunter-gatherer ancestors found themselves in. As Ravenhill notes, "feast or famine was the general rule." Nomadic groups ate large slabs of meat about once a week, and the gallbladder helped to quickly digest the onslaught of protein and fat.

Even though our diets and eating habits have changed drastically since then, evolution hasn't caught up—we still have the same digestive system. It's probably for this reason that "most meat-eating animals have a gallbladder," Zuchelkowski says. "Dogs do, cats do—they can concentrate bile just like we do, but I think you’d find that in animals that only eat vegetation, that’s where it’s likely to be missing.” However, Zuchelkowski notes that the gallbladder also helps you absorb fat-soluble vitamins like A, D, E, and K, so it still serves a useful function in people who are vegetarians.

4. ASTRONAUTS ARE ENCOURAGED TO GET THEIRS REMOVED.

A 2012 report from the Canadian Journal of Surgery recommended that astronauts consider having their appendix and gallbladder removed—even if their organs are perfectly healthy—to prevent appendicitis, gallstones, or cholecystitis from setting in when they’re far, far away from Earth's hospitals. “The ease and safety of surgical prophylaxis currently appears to outweigh the logistics of treating either acute appendicitis or cholecystitis during extended-duration space flight,” the authors wrote.

5. ALEXANDER THE GREAT LIKELY DIED FROM A GALLBLADDER GONE BAD.

Alexander may have been great at conquering entire empires, but his organs weren’t exactly up to the task. The king of Macedonia died at the age of 34, and some historians believe that the cause was peritonitis (inflammation of the peritoneum, the tissue lining the abdomen), which itself was a result of acute cholecystitis. “Historians have suggested that the fatal biliary tract disease was fueled by excess consumption of alcohol and overeating at a banquet that Alexander threw for his leading officers in Babylon,” author Leah Hechtman writes in Clinical Naturopathic Medicine.

6. THE DOCTOR WHO CONDUCTED THE FIRST SUCCESSFUL GALLSTONE REMOVAL SURGERY DIDN'T KNOW WHAT HE WAS LOOKING FOR.

Gallbladder-related ailments have been afflicting humans for thousands of years, as evidenced by gallstones found in Egyptian mummies. And for thousands of years, people put up with it because they didn’t know what was wrong or how to fix it. In fact, it wasn’t until 1867 that the first cholecystotomy (removal of gallstones) was carried out. The surgery was performed by Dr. John S. Bobbs of Indianapolis, who had no idea what ailed his patient, 31-year-old Mary Wiggins, until he cut open a sac that he later realized was her gallbladder and “several solid bodies about the size of ordinary rifle bullets” fell out, according to The Indianapolis Star. Amazingly, Wiggins survived and lived to the age of 77. Fifteen years after this surgery, the first cholecystectomy (removal of the gallbladder) was performed in Germany.

7. THE WORLD RECORD FOR MOST GALLSTONES EVER REMOVED FROM A PERSON'S BODY STANDS AT MORE THAN 23,000.

Unlike the Guinness World Record for most Twinkies devoured in one sitting, this isn’t the kind of record you’d enjoy setting. In 1987, an 85-year-old woman complaining of severe abdominal pain showed up at Worthing Hospital in West Sussex, England, and doctors found a shockingly high number of gallstones—23,530, to be exact. In May 2018, a similar (albeit less severe) case of gallstones was reported in India, where a 43-year-old man underwent surgery to have thousands of them removed. “Usually we get to see two to 20 stones, but here there were so many and when we counted them, it was a whopping 4100,” the surgeon told Fox News.

8. SOME EASTERN CULTURES BELIEVE THERE’S A LINK BETWEEN THE GALLBLADDER AND HEADACHES.

Some practitioners of Eastern medicine—especially Traditional Chinese Medicine (TCM)—purport that gallbladder problems can cause certain kinds of headaches. TCM practitioners say our internal organs are connected to channels called meridians, which direct several fundamental substances—like blood, other bodily fluids, and qi (vital life energy)—throughout the body. The gallbladder meridian, for instance, runs along the side of the head near the temple. Through the practice of acupuncture, tiny needles are inserted into the skin along the gallbladder meridian in an effort to relieve tension and free up blocked qi. (Western scientists tend to disagree on what, if any, benefit acupuncture offers.)

9. IN CHINA, BOLD PEOPLE ARE SAID TO HAVE A “BIG GALLBLADDER.”

Speaking of China, the country's primary language, Mandarin, hints at a link between organ function and personality. For instance, a word that’s assigned to bold and daring people translates to “big gallbladder,” and brave people are said to have “gallbladder strength,” according to The Conceptual Structure of Emotional Experience in Chinese. The word for coward, on the other hand, translates to “gallbladder small like mouse.” (Interestingly, mice do in fact have gallbladders, but rats don’t.)

10. WESTERN PHILOSOPHERS ALSO THOUGHT ONE'S TEMPERAMENT HAD TO DO WITH THE GALLBLADDER.

You may remember learning something about the four humors during a high school lesson on ancient Greece. The theory, originating with Hippocrates, held that a person’s temperament was influenced by one of four bodily fluids: black bile, yellow bile, phlegm, and blood. Yellow bile, stored in the gallbladder, was said to make people choleric, or irritable. Disease was blamed on an imbalance of these four humors, and this remained a popular theory up until the 18th century. Because of this theory's longstanding influence, the word gall—a synonym for bile—also meant “embittered spirit” during medieval times. It wasn’t until 1882 that the word took on the meaning of "impudence" or "boldness" in American English—as in “I can’t believe he had the gall to finish that Netflix series without me.”

11. ANCIENT ETRUSCANS USED THEM FOR DIVINATION.

Well, not human gallbladders. Ancient Etruscans, a group of people who once lived in present-day Tuscany and whose civilization became part of the Roman empire, practiced a type of divination called haruspicy. The soothsayers were called haruspices (literally “gut gazers”), and they looked for clues from the gods in the markings, coloring, and shape of a sacrificial sheep’s liver and gallbladder. This was often done before the Romans went into battle, but the practice was never adopted as part of the state religion.

12. SOME GALLBLADDERS SPORT A PHRYGIAN CAP.

A crease called a "Phrygian cap" at the base of the gallbladder occurs in about 4 percent of people. Its odd name is something of a misnomer. It comes from its resemblance to a type of peaked felt hat called a pileus, worn by emancipated slaves in ancient Rome; the design was similar to the peaked caps then worn in Phrygia, a region in modern-day Turkey. Much later, during the French Revolution, people took to wearing Phrygian caps—which they likely confused with the pileus's style—as symbols of their freedom from tyranny. In the 20th century, the Smurfs started wearing them.

As for the aforementioned gallbladder abnormality, there’s no deeper symbolism in its name. The way it folds over just looks a lot like a Phrygian cap. Despite being a “congenital anomaly,” as a 2013 study published in Case Reports in Gastroenterology puts it, the condition typically causes no symptoms or complications.

7 Facts About Blood

Moussa81/iStock via Getty Images
Moussa81/iStock via Getty Images

Everyone knows that when you get cut, you bleed—a result of the constant movement of blood through our bodies. But do you know all of the functions the circulatory system actually performs? Here are some surprising facts about human blood—and a few cringe-worthy theories that preceded the modern scientific understanding of this vital fluid.

1. Doctors still use bloodletting and leeches to treat diseases.

Ancient peoples knew the circulatory system was important to overall health. That may be one reason for bloodletting, the practice of cutting people to “cure” everything from cancer to infections to mental illness. For the better part of two millennia, it persisted as one of the most common medical procedures.

Hippocrates believed that illness was caused by an imbalance of four “humors”—blood, phlegm, black bile, and yellow bile. For centuries, doctors believed balance could be restored by removing excess blood, often by bloodletting or leeches. It didn’t always go so well. George Washington, for example, died soon after his physician treated a sore throat with bloodletting and a series of other agonizing procedures.

By the mid-19th century, bloodletting was on its way out, but it hasn’t completely disappeared. Bloodletting is an effective treatment for some rare conditions like hemochromatosis, a hereditary condition causing your body to absorb too much iron.

Leeches have also made a comeback in medicine. We now know that leech saliva contains substances with anti-inflammatory, antibiotic, and anesthetic properties. It also contains hirudin, an enzyme that prevents clotting. It lets more oxygenated blood into the wound, reducing swelling and helping to rebuild tiny blood vessels so that it can heal faster. That’s why leeches are still sometimes used in treating certain circulatory diseases, arthritis, and skin grafting, and helps reattach fingers and toes. (Contrary to popular belief, even the blood-sucking variety of leech is not all that interested in human blood.)

2. Scientists didn't understand how blood circulation worked until the 17th century.

William Harvey, an English physician, is generally credited with discovering and demonstrating the mechanics of circulation, though his work developed out of the cumulative body of research on the subject over centuries.

The prevailing theory in Harvey’s time was that the lungs, not the heart, moved blood through the body. In part by dissecting living animals and studying their still-beating hearts, Harvey was able to describe how the heart pumped blood through the body and how blood returned to the heart. He also showed how valves in veins helped control the flow of blood through the body. Harvey was ridiculed by many of his contemporaries, but his theories were ultimately vindicated.

3. Blood types were discovered in the early 20th century.

Austrian physician Karl Landsteiner discovered different blood groups in 1901, after he noticed that blood mixed from people with different types would clot. His subsequent research classified types A, B and O. (Later research identified an additional type, AB). Blood types are differentiated by the kinds of antigens—molecules that provoke an immune system reaction—that attach to red blood cells.

People with Type A blood have only A antigens attached to their red cells but have B antigens in their plasma. In those with Type B blood, the location of the antigens is reversed. Type O blood has neither A nor B antigens on red cells, but both are present in the plasma. And finally, Type AB has both A and B antigens on red cells but neither in plasma. But wait, there’s more! When a third antigen, called the Rh factor, is present, the blood type is classified as positive. When Rh factor is absent, the blood type is negative.

Scientists still don’t understand why humans have different blood types, but knowing yours is important: Some people have life-threatening reactions if they receive a blood type during a transfusion that doesn’t “mix” with their own. Before researchers developed reliable ways to detect blood types, that tended to turn out badly for people receiving an incompatible human (or animal!) blood transfusion.

4. Blood makes up about 8 percent of our total body weight.

Adult bodies contain about 5 liters (5.3 quarts) of blood. An exception is pregnant women, whose bodies can produce about 50 percent more blood to nourish a fetus.)

Plasma, the liquid portion of blood, accounts for about 3 liters. It carries red and white blood cells and platelets, which deliver oxygen to our cells, fight disease, and repair damaged vessels. These cells are joined by electrolytes, antibodies, vitamins, proteins, and other nutrients required to maintain all the other cells in the body.

5. A healthy red blood cell lasts for roughly 120 days.

Red blood cells contain an important protein called hemoglobin that delivers oxygen to all the other cells in our bodies. It also carries carbon dioxide from those cells back to the lungs.

Red blood cells are produced in bone marrow, but not everyone produces healthy ones. People with sickle cell anemia, a hereditary condition, develop malformed red blood cells that get stuck in blood vessels. These blood cells last about 10 to 20 days, which leads to a chronic shortage of red blood cells, often causing to pain, infection, and organ damage.

6. Blood might play a role in treating Alzheimer's disease.

In 2014, research led by Stanford University scientists found that injecting the plasma of young mice into older mice improved memory and learning. Their findings follow years of experiments in which scientists surgically joined the circulatory systems of old and young mice to test whether young blood could reverse signs of aging. Those results showed rejuvenating effects of a particular blood protein on the organs of older mice.

The Stanford team’s findings that young blood had positive effects on mouse memory and learning sparked intense interest in whether it could eventually lead to new treatments for Alzheimer’s disease and other age-related conditions.

7. The sight of blood can make people faint.

For 3 to 4 percent of people, squeamishness associated with blood, injury, or invasive medical procedures like injections rises to the level of a true phobia called blood injury injection phobia (BII). And most sufferers share a common reaction: fainting.

Most phobias cause an increase in heart rate and blood pressure, and often muscle tension, shakes, and sweating: part of the body’s sympathetic nervous system’s “fight or flight” response. But sufferers of BII experience an added symptom. After initially increasing, their blood pressure and heart rate will abruptly drop.

This reaction is caused by the vagus nerve, which works to keep a steady heart rate, among other things. But the vagus nerve sometimes overdoes it, pushing blood pressure and heart rate too low. (You may have experienced this phenomenon if you’ve ever felt faint while hungry, dehydrated, startled, or standing up too fast.) For people with BII, the vasovagal response can happen at the mere sight or suggestion of blood, needles, or bodily injury, making even a routine medical or dental checkup cause for dread and embarrassment.

What Purpose Does the Belly Button Serve?

misuma/iStock via Getty Images
misuma/iStock via Getty Images

While your eyelashes are protecting your eyes, your lungs are letting you breathe, and virtually every other part of your body—inside and out—is performing its own relatively well-known task, your belly button is just sitting there collecting lint. And while it’s true that your navel served its most important purpose before you were born, it’s not totally useless now.

According to ZME Science, back when you were a fetus, your belly button was more of a belly portal: Your umbilical cord extended from it and connected you to the placenta on your mother’s uterine wall. That way, the placenta could channel nutrients and oxygen to you through the cord, and you could send back waste.

Your umbilical cord was cut when you were born, creating a tiny bulge that left behind some scar tissue after it healed. That scar tissue is your belly button, navel, or umbilicus. Though you may have heard that the shape of your belly button is a direct result of the scissor skills of the doctor who delivered you, that’s not true. Dr. Dan Polk, a neonatologist in the Chicago area, told the Chicago Tribune that a belly button's shape “has to do with how much baby skin leads onto the umbilical cord from the baby’s body. Less skin makes an innie; more skin makes an outie.” About 90 percent of people have innies.

Regardless of how your belly button looks, you probably don’t use it on a daily basis. However, if you’ve studied anatomy, medicine, or a related field, you might recognize it as the central point by which the abdomen is divided into the following quadrants: right upper, left upper, right lower, and left lower. Another way of classifying that area is into nine regions—including the hypochondriac, lumbar, iliac, epigastric, and hypogastric regions—with the umbilical region at the very center.

Abdominopelvic regions diagram
Blausen Medical, Wikimedia Commons // CC BY 3.0

Your belly button can also serve as the opening for laparoscopic surgery, which can save you from having a scar elsewhere on your abdomen.

The navel is a great central landmark outside of medicine, too. If you’ve taken yoga or Pilates classes, you may have heard it referred to as the center of balance or center of gravity. Because it sits right on top of your abdominal muscles, your belly button is an easy marker for your instructor to mention when they want you to access your core, which helps you balance.

And, of course, belly buttons are notorious for storing quite a bit of lint, which always seems to be blue (you can learn more about that here).

Have you got a Big Question you'd like us to answer? If so, let us know by emailing us at bigquestions@mentalfloss.com.

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