A Breakthrough Global Study of Depression Finds 44 Genetic Variants Linked to the Disease

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Though depression affects an estimated 14 percent of the world’s population, scientists know very little about the underlying causes of the disorder, and that makes it incredibly difficult to treat. Even now, researchers are still debating whether common antidepressant medications even work at all, and if they do, why.

New research published in the journal Nature Genetics provides a big step in figuring out why some people suffer from depression while others don’t, identifying 44 genetic variants that are risk factors for major depression, 30 of which are new. They also found two regions of the brain that appear to be associated with the development of the disorder.

The study is the result of an international effort by more than 200 researchers involved with the Psychiatric Genomics Consortium. It looked at more than 135,000 cases of depression (both self-reported and clinically assessed) and almost 345,000 control cases. It’s the largest study on the genetic basis of depression ever done.

The researchers found that all humans carry some of the 44 risk factors identified. Some people carry more than others, putting them at greater risk for developing depression. They also identified the prefrontal and anterior cingulate cortices (both located at the front of the brain) as the regions of the brain probably linked with the development of depression.

Some of the risk factors the researchers identified are also involved in other psychiatric disorders, like schizophrenia, which isn't entirely surprising—a 2007 study from the Psychiatric Genomics Consortium found that people with depression, bipolar disorder, and schizophrenia as well as developmental disorders like ADHD and autism share the same variations in four locations in their genetic code.

By identifying genetic risk factors associated with major depressive disorder, the scientists hope to increase our understanding of why depression strikes some people and not others. "[M]ajor depression is a brain disorder," the researchers conclude. "Although this is not unexpected, some past models of [major depressive disorder] have had little or no place for heredity or biology." They firmly put to rest the idea that depression is entirely a matter of environment.

Environment certainly plays a role—the researchers found links between lower education levels and higher body mass index and depression risk as well—but genetics may impact whether someone whose circumstances put them at risk of depression actually develops the disorder. Depression is still highly stigmatized, which often prevents people from seeking treatment for it, according to several studies. Further understanding of the genetic underpinnings of the disorder may help counter negative perceptions of depression as a character flaw or a sign of laziness.

The study could eventually change how doctors treat depression. Many of the genetic variants identified by this study are linked to targets of current antidepressant medications, like serotonin. But the research may also lead to the development of new medications and therapies that could work for more people (current medications don't work for everyone) and potentially have fewer side effects than existing treatments.

The study partially relied on self-reported depression diagnoses, meaning there's some wiggle room in knowing whether those people are actually clinically depressed to the degree that a medical professional would diagnose. Further research will need to confirm that these genetic variants are indeed linked to depression. There are likely even more gene variants related to depression risk, as well, but they might have too small of an effect to be identified by this study. The researchers hope to continue their work to understand the links between environmental stressors, genetic variations, and depression risk in the future.

These 8 MasterClass Courses Will Get You Out of Your Netflix Funk

Chef Gordon Ramsay is just one of the professionals lending their knowledge to a MasterClass course.
Chef Gordon Ramsay is just one of the professionals lending their knowledge to a MasterClass course.
Franco Origlia/Getty Images

Although binge-watching Netflix is always a great way to kill a few hours, you might want to shake it up and do something a little more substantial with your free time. That’s where MasterClass comes in. A subscription package that features over 80 virtual courses in a wide range of subjects, MasterClass can help you explore exciting new subjects or improve your knowledge in an area you’re already familiar with. And all the classes are taught by highly recognizable experts in their fields, so you can be confident that the lessons you’re learning are solid (that Martin Scorsese probably knows a thing or two about filmmaking, after all).

The courses themselves are broken up into individual lessons that are only around 10 minutes long, so fitting them into your schedule is as easy as becoming a professional chess player (or it will be, once you’ve finished the course). MasterClass is priced at $15 a month for unlimited classes or at $90 per course, and you can sign up here.

So whether you want to become the next great young adult novelist or an expert bartender, MasterClass has something for everyone. Check out a few highlights from the course list.

1. Cooking with Gordon Ramsay

Gordon Ramsay, known for his sharp demeanor and high expectations in the kitchen, is an international chef, restaurateur, and television host who’s nothing short of legendary. And in his MasterClass series, he’ll teach you to become a legend, too. This series features the softer side of Ramsay, who teaches you knife techniques, seasoning tricks, kitchen layout, and much more. And, for anyone ready to level up, he also offers Cooking II: Restaurant Recipes in the Kitchen.

Sign up here.

2. Mixology with Lynnette Marrero & Ryan Chetiyawardana

If you’re ready to become an award-winning bartender—or just make a decent martini at home—look no further than this 17-lesson course with master mixologists Lynnette Marrero and Ryan Chetiyawardana. You’ll not only learn to craft the perfect cocktail, but also how to safely incorporate raw eggs into drinks, make complementary drink “seasonings,” and discover the best liquor to pair with food (who knew that whiskey and blue cheese were a match made in heaven?). A good drink has the power to bring people together, and after this course, you’ll be the go-to guru for any dinner party.

Sign up here.

3. Writing for Young Adults With R.L. Stine

After you’re through with R.L. Stine’s class on writing for young adults, you may just become the next sultan of the Scholastic Book Fair. According to his website, Stine has written over 330 books over the course of his career, and he’s provided thrills and chills to millions of readers with his beloved Goosebumps and Fear Street series. Now, he’ll teach you some of his favorite tricks of the trade, like why you should always start with the ending (so you can focus on fooling your reader for the entire book) and how writing from personal experience makes for a more sincere scare. This masterclass will help you perfect the art of scary storytelling and overcome any fears you might have about putting your own experiences on the page.

Sign up here.

4. Conservation with Dr. Jane Goodall

Dr. Jane Goodall is best known for her groundbreaking work with chimpanzees and gorillas, but she’s more than just a scientist—she’s an environmental activist and conservationist who wants to ensure that animal habitats are preserved for years to come. In this course, Dr. Goodall will share some of the conservation lessons she’s learned as a scientist, identify the central problems facing our planet today, and share effective methods for creating change. As she says, one of the best ways to confront environmental issues is by “telling stories, meeting with people, listening to them, and then finding a way to reach the heart.” This course will show you how.

Sign up here.

5. Chess with Garry Kasparov

Garry Kasparov, a chess grandmaster and world chess champion, will help you dust off your old chessboard and learn to play the game like it’s an art form. This 29-lesson class starts with the basics and gets more complex the further you get into the course. Using the tactics he’s curated throughout his career, Kasparov will show you how to approach chess with a strategist's mindset, including the basics of openings, interference plans, and endgames. This class even features other “students” so you’re not just studying the techniques, but seeing how they play out in real time, too.

Sign up here.

6. Comedy with Steve Martin

One of comedy’s greatest names—and one of film’s most beloved actors—is Steve Martin. The star of film classics such as Father of the Bride and Planes, Trains, and Automobiles, Martin will teach you how to find your comedic voice, develop your persona, and work a crowd so that you’ll never get booed off the stage. And he’ll share his comedic process, which involves more writing and editing than it does practicing in the mirror. This is the perfect class for anyone looking to practice their improv skills or sign up for their first open mic night.

Sign up here.

7. Space Exploration with Chris Hadfield

Make your childhood dreams come true with this course from retired astronaut Chris Hadfield, who’s flown two Space Shuttle missions and served as commander of the International Space Station during his 21 years as an astronaut. And in his course, he’ll teach you the intricacies of space exploration, from learning how rockets work to preparing your body for liftoff. Even if you're not planning on leaving the atmosphere (or your couch) anytime soon, this class teaches you what it's like to be an astronaut. And as Hadfield talks about his unique journey to the stars, there's the chance to learn plenty of life and career lessons that you can apply on Earth.

Sign up here.

8. Adventure Photography with Jimmy Chin

Even if your biggest adventure is going on a walk in your local park, award-winning adventure photographer Jimmy Chin (the face behind documentaries such as Free Solo and Meru) will still teach you how to turn your photographs into works of art. Chin’s class acts as part photography course and part adventure guide, teaching you every step from choosing the right location to editing the final product. You’ll learn how to plan shoots, pack the right gear, and even find clients if you want to go professional. Whether you want to make photography a career or just take the perfect photo of your dog at golden hour, this masterclass will get you feeling comfortable behind the camera and bring some more adventure into your everyday life.

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20 Boredom-Busting Science Experiments You Can Do at Home, Courtesy of YouTube’s Physics Girl

YouTube's Physics Girl snuffs out a candle with carbon dioxide.
YouTube's Physics Girl snuffs out a candle with carbon dioxide.
Physics Girl, YouTube

YouTube sensation Physics Girl is keeping boredom at bay in the best way possible: with DIY science experiments that you can recreate on your own.

In the video below, she challenges herself to complete all 20 experiments in five minutes—not including the time it takes to set everything up—which amounts to 15 seconds for each one. Parents who are homeschooling their kids (or adults who just have a little more free time than usual while in self-isolation) can, of course, slow them down to a more leisurely pace or even spread them out over a few weeks.

You probably already have a lot of the materials you’ll need, like eggs, candles, soda cans, oil, water, pans, and other basic household items. Some experiments are simple and kid-safe—like spinning a hard-boiled egg on its side until it stands on its end—while others require adult supervision, like blowing out a candle and relighting it without actually touching the lighter to the wick.

A few of them might end up entertaining kids (or you) for much longer than the duration of the experiment itself. A mixture of cornstarch and tonic water, for example, creates a slime-like substance called a non-Newtonian fluid, meaning it can act like a solid or a liquid, depending on how you handle it. (If you don’t have tonic water, here’s how to make it with regular water.)

And after you’ve mastered all the challenges and spent hours letting cornstarch slime run through your fingers at various viscosities, there are many more wonders to behold on Physics Girl’s YouTube channel, which is run by PBS Digital Studios. There, the MIT graduate (also known as Dianna Cowern) explores why Tic Tacs sometimes bounce higher on the second bounce, investigates whether it’s possible to power a house with a ShakeWeight, and plenty more.

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