12 Common Things Science Still Hasn't Figured Out

Laughter: Still a scientific mystery
Laughter: Still a scientific mystery
iStock/pixelfit

We’ve learned enough about physics to send humans to the Moon. We’ve discovered that DNA carries our genetic information. Scientists have even gotten closer to solving the mystery of whether cats can behave as both solids and liquids [PDF].

But there are still some basic questions we haven’t answered, including these frustratingly persistent scientific mysteries.

1. Why We Cry

Some of us tear up watching a sad movie; sometimes, we're so happy that we burst into tears. But according to science, crying in response to intense emotions doesn’t seem to be a useful behavior, and it might not have a biological purpose.

What science does know is that not all tears are created equal. The chemical composition of the tears produced when we cry, which are called psychic tears, is slightly different from the composition of the tears that lubricate and help expel foreign bodies from the eyes. This has led some to theorize that the chemical makeup of psychic tears makes them emotionally healing. But evidence showing that the chemical differences have substantial psychological effects—let alone that such effects explain why crying evolved—is lacking.

And that’s not where the theories end. Some evolutionary psychologists think that crying may have evolved as a distress call that brings help: In a 2009 paper, one researcher suggested that tears may signal submission and helplessness by blurring vision, which prompts others to aid (or at least not harm) the crier. But other researchers have pointed out that we often cry after a stressful situation has resolved, not while it’s in progress and we need to signal for help; it’s also typical for people to avoid crying publicly and to look unfavorably on those who do. In any case, these hypotheses, like most in evolutionary psychology, are difficult to test.

2. How to Cure Hiccups

Maybe you hold your breath. Maybe you chug water. Unfortunately, nothing has been found to reliably eliminate hiccups, despite the overwhelming number of folk remedies on the internet. This sad state of affairs is likely due to insufficient research: Serious cases of the hiccups are rare, and the mild cases are brief and don’t usually cause problems.

Most of the treatments for severe cases of hiccups—doses of sedating antipsychotics like haloperidol, vagus nerve stimulation, digital rectal massage—aren’t exactly things you could try on your own. For now, you’ll have to endure hiccups or stick with unproven, but usually harmless, solutions. At least they give you an excuse to eat peanut butter by the spoonful.

3. How General Anesthesia Works

As you’re rolling into surgery, you probably assume that your doctors not only know how to perform the procedure, but understand how the drugs that knock you out actually do so. But you’d be wrong. Scientists do know that local anesthetics like Novocain block pain signals before they reach the central nervous system by altering the function of specific proteins on nerve cells. But the molecular basis of general anesthesia is more of a mystery. These drugs seem to interfere with the functions of a variety of proteins on nerve cells in the central nervous system, but how they accomplish this is not well understood. General anesthetics come in a variety of types, and they likely don’t all work the same way, so developing models of how the compounds work on the molecular level may continue to be a challenge.

4. How Tylenol Kills Pain

A layperson taking Tylenol to relieve pain might think it works like non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and aspirin, which block some enzymes and, in turn, the pain- and inflammation-causing chemicals they produce. But that’s not the case—acetaminophen, the active ingredient in Tylenol, seems to need specific chemical conditions to work on those enzymes, and it doesn’t appear to reduce inflammation as the NSAIDs do.

Some researchers think acetaminophen may alter the way pain is perceived by interacting with certain proteins on nerve cells, possibly including serotonin receptors, cannabinoid receptors, opioid receptors, and specific channels on nerves in the spinal cord that transmit pain and itch signals. Acetaminophen byproducts have also been shown to activate these channels rather than shutting them down, further complicating the question.

5. Why We Sleep

Too little sleep impairs thinking in the short term and increases the risk of several serious diseases in the long term, while complete sleep deprivation is fatal. We may have evolved to sleep because it aids healing, memory consolidation, and other important processes, but we still have much to learn about the ways sleeping achieves these ends. Other roles for sleep, like conserving energy during times when it wouldn’t be advantageous to be awake (for example, during scorching-hot days in Death Valley) have been proposed as well.

At least for now, we don’t have a single, conclusive answer to the question of why we sleep. But no matter how sleeping arose, we can probably accept that it provided a substantial evolutionary advantage once in place, since sleep is found across much of the animal kingdom.

6. Why Only Some Thunderstorms Produce Tornadoes

A standard explanation of how tornadoes form is that they’re spawned when cold, dry air mingles with warm, humid air—that’s how we justify the fact that Tornado Alley in the central United States, where Arctic air, air from the Southwest, and air from the Gulf of Mexico mix, has so many tornadoes. But that’s not the whole story. These conditions do create more thunderstorms, but not all thunderstorms include tornadoes, and scientists aren’t sure why.

In some cases, tornadoes may form is when there are temperature changes in the air flowing downward around mesocyclones (vortexes within the types of storms tornadoes can come from). This idea has theoretical and experimental support, but even without these temperature variations, tornadoes can still form, demonstrating how much more we have to learn about the phenomenon.

7. Why We Itch

At a basic level, itch is an unpleasant sensation that triggers the urge to scratch. Scratching could end up making an itch worse, but it may also serve a purpose. Mechanical itch—the kind triggered when fine hairs on your body are disturbed—may alert you to the presence of biting insects or parasites, and scratching could brush them away.

This hypothesis is difficult to test, and it doesn’t cover chemical itch caused by histamine and other scratch-provoking substances. Long after you’ve missed your chance to brush a mosquito off your skin, histamine in the itchy bump it has left behind continues to compel you to scratch. Whether this type of itching serves a purpose, or is simply an incidental activation of the itch system, isn’t conclusively known.

8. How We Age

Despite what many beauty experts claim, no one really has aging figured out. Reactive chemicals called free radicals are often blamed, but they’re not the sole cause of aging, and our cells have numerous ways to help keep damage caused by excess free radicals to a minimum. Shortening of the telomeres, the protective caps of DNA at the ends of each chromosome, is another frequently cited cause of aging—but it’s not the only factor. Numerous other contributors to aging have been discovered, but no single factor explains all or even most of the aging process, making this a difficult question to answer.

9. Why We Laugh

Laughter, like crying, may have developed as a social tool. Laughter doesn't appear to be a uniquely human behavior, and it may not even be limited to primates. Rats produce laughter when tickled, for example, and many other social animals, such as dolphins [PDF], make specific sounds associated with play-fighting that have been likened to laughter.

A leading hypothesis for why we laugh is that laughter promotes pro-social behavior by letting playmates know that the fighting is just a game. But even if our interpretations of these behaviors are correct, it’s possible that humans evolved different uses for laughter after our evolutionary splits with other animal species, making the reason for human laughter another open question.

10. How and Why Animals Migrate Back to Their Birthplaces

Some animals migrate to the sites of their birth to mate—a practice known as natal philopatry—with stunning precision. Female Antarctic fur seals, for example, can return to within one body length of their exact birthplaces to breed.

But how do they get there after months or years away? One possibility is that some migratory animals navigate by sensing variations in Earth’s geomagnetic field. While this makes sense given that some migratory animals, such as sea turtles, are known to be highly sensitive to these variations, it has not been conclusively demonstrated that they navigate this way.

Other creatures, such as Pacific salmon, may use smell to direct them toward their breeding grounds. These fish have been shown experimentally to be able to home in on chemical cues from the water in which they developed into adults. But these chemical breadcrumbs wouldn’t be detectable across the vast ocean, meaning that even if the salmon use them to navigate, they must also have a way to direct themselves close enough to the source to smell them. The complete mechanisms behind natal philopatry, even in this well-studied case, are still unknown.

11. What Dreams are For

If the question of why we sleep is complicated, the question of why we dream is even more so. Dreaming—especially with vivid, fanciful dreams—is most correlated with rapid eye movement (REM) sleep, which itself is poorly understood. One thought is that dreaming evolved to help us sort out or rehearse solutions to problems in our waking lives, but there is no hard evidence that this is the case.

Although our dreams may feel significant to us, it’s also possible that they serve no purpose—they may simply be a byproduct of other processes that occur during REM sleep. Studying the neurological basis of the strange and highly subjective experience of dreaming is complicated, which is why understanding the origin of dreaming is still beyond our grasp.

12. How Turbulence Happens

Understanding how turbulence works is incredibly important from an engineering perspective, since it affects everything from how internal combustion engines work to how far golf balls can travel. And now that most of classical physics (encompassing the laws of mechanics, thermodynamics, and so on) has long been established, turbulence is considered one of the biggest remaining problems in the field. No one has figured out a way to perfectly model turbulent flow.

Modeling turbulence requires the Navier–Stokes equations, which describe the motion of fluids (liquids, gases, and plasmas). And that’s the main problem: These equations themselves are poorly understood—so much so that producing a proof about one of their basic properties is one of the seven Millennium Prize Problems. It’s considered one of the most important open classic questions in math—and there's a million dollars waiting for anyone who can figure it out.

Pandemic vs. Epidemic: What’s the Difference?

If scientists can't develop a vaccine for a new virus quickly enough, an epidemic can turn into a pandemic.
If scientists can't develop a vaccine for a new virus quickly enough, an epidemic can turn into a pandemic.
doble-d/iStock via Getty Images

As the new coronavirus continues to spread around the world, the words epidemic and pandemic are showing up in news reports more often than they usually do. While the terms are closely related, they don’t refer to the same thing.

As the Association for Professionals in Infection Control and Epidemiology (APIC) explains on its website, “an epidemic occurs when an infectious disease spreads rapidly to many people.” Usually, what precedes an epidemic is an outbreak, or “a sudden rise in the number of cases of a disease.” An outbreak can affect a single community or several countries, but it’s on a much smaller scale than an epidemic.

If an epidemic can’t be contained and keeps expanding its reach, public health officials might start calling it a pandemic, which means it’s affected enough people in different areas of the world to be considered a global outbreak. In short, a pandemic is a worldwide epidemic. It infects more people, causes more deaths, and can also have widespread social and economic repercussions. The spread of the Spanish influenza from 1918 to 1919, which killed between 20 and 40 million people around the world, was a pandemic; more recently, the H1N1 influenza created a pandemic in 2009.

Here’s where it gets a little tricky: There’s no cut-and-dried classification system for outbreaks, epidemics, and pandemics. Based on the definitions above, it might seem like the current coronavirus disease, now called COVID-19, falls into the pandemic category already—according to a map from the World Health Organization (WHO), there are more than 80,000 confirmed cases in 34 countries, and nearly 2700 people have died from the disease. It’s also beginning to impact travel, stock markets, and the global economy as a whole. But WHO maintains that although the situation has the potential to become a pandemic, it’s still an epidemic for now.

“It really is borderline semantics, to be honest with you,” Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told CNN earlier this month. “I think you could have people arguing each end of it. Pandemics mean different things to different people.”

[h/t APIC.org]

Fat Bats Might Be Resistant to Deadly White-Nose Syndrome

Penn State, Flickr // CC BY-NC-ND 2.0
Penn State, Flickr // CC BY-NC-ND 2.0

Good news for flying mammals: chubby little brown bats might be genetically resistant to white-nose syndrome, a fungal disease that’s killed more than 5.5 million bats since it was first documented in 2006 [PDF]. A new study in the journal Scientific Reports describes three genetic adaptations in the bats that could protect them from the pathogen.

Little brown bats (Myotis lucifugus), common in Canada and the eastern United States, are especially susceptible to white-nose syndrome. According to lead author Giorgia G. Auteri, a doctoral candidate at the University of Michigan, white-nose syndrome kills bats by disrupting their hibernation cycles.

“When they’re in hibernation in the winter, they’re not meant to be waking up. They’re supposed to be asleep,” Auteri tells Mental Floss. “But this fungus grows on them, and it causes the bats to keep waking up during hibernation. And because they’re waking up when they shouldn’t be, they’re running out of fat reserves too early.”

But while white-nose syndrome has devastated bat populations in North America, not all infected bats die from the disease—some recover. Auteri wanted to find out what made the survivors so special.

Auteri and her team compared the genetic makeup of nine surviving and 29 non-surviving little brown bats from northern Michigan. They discovered that survivors share three important genetic distinctions. “One is involved with fat metabolism,” she says. “And another is involved with regulating when the bats wake up from hibernation. And the third gene is involved in their echolocation ability, in their sonar for hunting insects.”

The results make sense, Auteri says. Because white-nose syndrome interrupts bats’ hibernation schedules, bats with genes that relate to more optimal fat storage (i.e., they’re fatter) and better hibernation regulation (i.e., they sleep longer) are more likely to survive the disease.

Auteri’s research could help scientists and conservationists find ways to preserve little brown bat populations. Besides being adorable, little brown bats also play an important ecological role as predators of insects like mosquitoes, moths, and other pests that are destructive to crops and forests.

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